dihydroxytryptamine

English Journal

Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats.

Izumi T, Ohmura Y, Futami Y, Matsuzaki H, Kubo Y, Yoshida T, Yoshioka M.SourceDepartment of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060-8638, Japan. Electronic address: psyizumi@med.hokudai.ac.jp.
European journal of pharmacology.Eur J Pharmacol.2012 Dec 5;696(1-3):89-95. doi: 10.1016/j.ejphar.2012.09.028. Epub 2012 Oct 1.
The amygdala and the medial prefrontal cortex (mPFC) are crucial brain structures for anxiety, and it is speculated that the serotonergic neural system in these structures has an important role in regulating anxiety. In our previous study, we indicated that local injections of selective serotonin re
PMID 23036373

Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways.

Biagioni AF, de Freitas RL, da Silva JA, de Oliveira RC, de Oliveira R, Alves VM, Coimbra NC.SourceLaboratório de Neuroanatomia & Neuropsicobiologia, Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Av. dos Bandeirantes 3900, Ribeirão Preto, SP 14049-900, Brazil; Instituto de Neurociências e Comportamento (INeC), Universidade de São Paulo (USP), Av. dos Bandeirantes 3900, Ribeirão Preto, SP 14040-901, Brazil; NAP-USP-Neurobiologia das Emoções (NuPNE), Departamento de Farmacologia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP), Av. dos Bandeirantes 3900, Ribeirão Preto, SP 14049-900, Brazil.
Neuropharmacology.Neuropharmacology.2012 Nov 29. pii: S0028-3908(12)00527-8. doi: 10.1016/j.neuropharm.2012.10.024. [Epub ahead of print]
Decrease of γ-aminobutyric acid (GABA)-mediated neurotransmission in the dorsomedial hypothalamus (DMH) evokes instinctive fear-like responses. The aim of the present study was to investigate the involvement of the serotonin (5-HT)- and norepinephrine-mediated pathways of the endogenous pain inhibi
PMID 23201351

Involvement of descending monoaminergic systems in antiallodynic effect of goshajinkigan in oxaliplatin-treated mice

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Journal of Traditional Medicines 30(4), 183-189, 2013
… The antiallodynic activity of GJG was inhibited by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine (20 μg/site) and the serotonergic neurotoxin 5,7-dihydroxytryptamine (20 μg/site). …
NAID 130004942434

Property of Regenerating Serotonin Fibers in the Hippocampus of Human Migration Disorders Model

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Kansei Engineering International Journal 11, 139-145, 2012
… After neonatal intracisternal 5, 7-dihydroxytryptamine (DHT) injection, these 5-HT fibers degenerate and disappear throughout the forebrain, and then regenerating 5-HT fibers densely innervate in the hippocampal heterotopia. …
NAID 130002148650

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

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Journal of pharmacological sciences 115(3), 417-420, 2011-03-20
… The biting was increased by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine and the <I>α</I>-adrenoceptor antagonist phentolamine but not the serotonergic neurotoxin 5,7-dihydroxytryptamine. …
NAID 10029892967