ジヒドロピリミジン
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- 1. 化学療法剤の腸管毒性enterotoxicity of chemotherapeutic agents [show details]
…well-studied predictive factors are enzymatic activity of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthetase Dihydropyrimidine dehydrogenase (DPD), the first of three enzymes in the fluoropyrimidine …
- 2. フルオロピリミジンによる心毒性：発生率、臨床症状、発生機序、マネージメントfluoropyrimidine associated cardiotoxicity incidence clinical manifestations mechanisms and management [show details]
…remain anecdotal and have not been statistically confirmed. The influence of polymorphisms in dihydropyrimidine dehydrogenase (DPD), the initial and rate-limiting enzyme in FU catabolism, on cardiotoxicity …
- 3. 化学療法に起因する急性下痢のマネージメントmanagement of acute chemotherapy related diarrhea [show details]
…fluoropyrimidine, in whom deficiency of one of the fluoropyrimidine metabolizing enzymes (ie, dihydropyrimidine dehydrogenase [DPD] or thymidylate synthetase) is suspected, or who have had an unintentional …
- 4. 転移性大腸癌に対する全身化学療法：終了した臨床試験systemic chemotherapy for metastatic colorectal cancer completed clinical trials [show details]
…inactive compounds. Interpatient variation in the activity of the critical metabolizing enzyme dihydropyrimidine dehydrogenase (DPD) may account for toxicity differences . Individuals who lack DPD develop …
- 5. 成人における抗癌剤の投与dosing of anticancer agents in adults [show details]
…the drugs are contraindicated in patients with known deficiency in the metabolizing enzyme dihydropyrimidine dehydrogenase (DPD). A test (TheraGuide 5-FU) is commercially available to detect the most common…
English Journal
- Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.
- Lokwani D1, Azad R2, Sarkate A1, Reddanna P2, Shinde D3.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Aug 1;23(15):4533-43. doi: 10.1016/j.bmc.2015.06.008. Epub 2015 Jun 11.
- The various scaffolds containing 1,4-dihydropyrimidine ring were designed by considering the environment of the active site of COX-1/COX-2 and 5-LOX enzymes. The structure-based library design approach, including the focused library design (Virtual Combinatorial Library Design) and virtual screening
- PMID 26122769
- Prognostic Value of Excision Repair Cross-Complementing Gene 1, Dihydropyrimidine Dehydrogenase, and Human Equilibrative Nucleotide Transporter 1 Expression and Their Implications for Adjuvant Treatment in Patients With Ampullary Carcinoma.
- Kawabata Y1, Nishi T, Kidani A, Tajima Y.
- Pancreas.Pancreas.2015 Aug;44(6):937-44. doi: 10.1097/MPA.0000000000000348.
- OBJECTIVES: The purpose of this study was to characterize the intratumoral expression profiles of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase (DPD), and human equilibrative nucleotide transporter 1 (hENT1) in ampullary carcinomas (ACs) to evaluate their progno
- PMID 25906447
- Genotype-phenotype correlations in 5-fluorouracil metabolism: a candidate DPYD haplotype to improve toxicity prediction.
- Gentile G1, Botticelli A2, Lionetto L3, Mazzuca F4, Simmaco M1, Marchetti P4, Borro M1.
- The pharmacogenomics journal.Pharmacogenomics J.2015 Jul 28. doi: 10.1038/tpj.2015.56. [Epub ahead of print]
- 5-Fluorouracil is among the most widely used anticancer drug, but a fraction of treated patients develop severe toxicity, with potentially lethal injuries. The predictive power of the available pretreatment assays, used to identify patients at risk of severe toxicity, needs improvements. This study
- PMID 26216193
Japanese Journal
- Effect of Metabolic Inhibitors on the Hepatic Disposition of 5-Fluorouracil after Application to the Rat Liver Surface
- Calix[8]arene Sulfonic Acid Catalyzed Three-Component Reaction for Convenient Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones/thiones under Ultrasonic Irradiation
- Calix[8]arene Sulfonic Acid Catalyzed Three-component Reaction for Convenient Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones/thiones under Ultrasonic Irradiation
Related Links
- このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10126/3300 タイトル: Combined evaluation of dihydropyrimidine dehydrogenase and thymidine phosphorylate mRNA levels in tumor predicts the ...
- 例：39歳男性 全身倦怠感・発熱・歯肉出血にて受診 考察 癌と化学療法 癌と化学療法社 ... Dihydropyrimidine Dehydrogenase(DPD)欠損症と診断された再発胃癌の1例 複写代金：630円(税抜600円)
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- dihydrouracil dehydrogenase NADP、DPD
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