ジヒドロジピコリン酸還元酵素、ジヒドロジピコリン酸レダクターゼ
WordNet
- an enzyme that catalyses the biochemical reduction of some specified substance
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/06/23 07:22:35」(JST)
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| 4-hydroxy-tetrahydrodipicolinate reductase |
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Dihydrodipicolinate reductase tetramer, Corynebacterium glutamicum
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| Identifiers |
| EC number |
1.17.1.8 |
| CAS number |
9055-46-3 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / QuickGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction
- (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+
The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+ or NADP+, and H2O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H+.
This enzyme participates in lysine biosynthesis.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:
- dihydrodipicolinate reductase,
- dihydrodipicolinic acid reductase, and
- 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.
References
Further reading
- Farkas W, Gilvarg C (Dec 1965). "The reduction step in diaminopimelic acid biosynthesis". The Journal of Biological Chemistry. 240 (12): 4717–22. PMID 4378965.
- Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. doi:10.1016/0076-6879(71)17030-9.
- Devenish SR, Blunt JW, Gerrard JA (Jun 2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". Journal of Medicinal Chemistry. 53 (12): 4808–12. doi:10.1021/jm100349s. PMID 20503968.
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Other oxidoreductases (EC 1.15-1.21)
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| 1.15: Acting on superoxide as acceptor |
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| 1.16: Oxidizing metal ions |
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| 1.17: Acting on CH or CH2 groups |
- Xanthine oxidase
- Ribonucleotide reductase
- 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
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| 1.18: Acting on iron-sulfur proteins as donors |
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| 1.19: Acting on reduced flavodoxin as donor |
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| 1.20: Acting on phosphorus or arsenic in donors |
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| 1.21: Acting on X-H and Y-H to form an X-Y bond |
- Isopenicillin N synthase
- Columbamine oxidase
- Reticuline oxidase
- Sulochrin oxidase
- (+)-bisdechlorogeodin-forming
- (-)-bisdechlorogeodin-forming
- Aureusidin synthase
- Tetrahydrocannabinolic acid synthase
- Cannabidiolic acid synthase
- Dichlorochromopyrrolate synthase
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
- Enzyme activator
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
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UpToDate Contents
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English Journal
- Structural Insight into Dihydrodipicolinate Reductase from Corybebacterium glutamicum for Lysine Biosynthesis.
- Sagong HY1, Kim KJ1.
- Journal of microbiology and biotechnology.J Microbiol Biotechnol.2016 Feb 28;26(2):226-32. doi: 10.4014/jmb.1508.08086.
- Dihydrodipicolinate reductase is an enzyme that converts dihydrodipicolinate to tetrahydrodipicolinate using an NAD(P)H cofactor in L-lysine biosynthesis. To increase the understanding of the molecular mechanisms of lysine biosynthesis, we determined the crystal structure of dihydrodipicolinate redu
- PMID 26502738
- Cloning, Expression, and Purification of Histidine-Tagged Escherichia coli Dihydrodipicolinate Reductase.
- Trigoso YD1, Evans RC1, Karsten WE2, Chooback L1.
- PloS one.PLoS One.2016 Jan 27;11(1):e0146525. doi: 10.1371/journal.pone.0146525. eCollection 2016.
- The enzyme dihydrodipicolinate reductase (DHDPR) is a component of the lysine biosynthetic pathway in bacteria and higher plants. DHDPR catalyzes the NAD(P)H dependent reduction of 2,3-dihydrodipicolinate to the cyclic imine L-2,3,4,5,-tetrahydropicolinic acid. The dapB gene that encodes dihydrodipi
- PMID 26815040
- Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome.
- Shokry IM1, Callanan JJ1, Sousa J2, Tao R3.
- Journal of visualized experiments : JoVE.J Vis Exp.2015 Sep 23;(103). doi: 10.3791/53165.
- 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) toxicity may cause region-specific changes in serotonergic mRNA expression due to acute serotonin (5-hydroxytryptamine; 5-HT) syndrome. This hypothesis can be tested using in situ hybridization to detect the serotonin 5-HT2A receptor gene htr2a. In t
- PMID 26437182
Japanese Journal
- Disruption of metF Increased L-Lysine Production by Methylophilus methylotrophus from Methanol
- Ishikawa Kohei,Asahara Takayuki,Gunji Yoshiya [他],YASUEDA Hisashi,ASANO Kozo
- Bioscience, biotechnology, and biochemistry 72(5), 1317-1324, 2008-05-23
- … (<I>dapA24</I>) encoding a dihydrodipicolinate synthase desensitized from feedback inhibition by L-lysine, and mutated <I>lysE</I> … A single-base substitution was identified in this auxotroph in codon-329 of the open reading frame of <I>metF</I>, encoding 5,10-methylene-tetra-hydrofolate reductase. …
- NAID 10027527962
- Characterization of Dihydrodipicolinate Reductase from Thermotoga maritima Reveals Evolution of Substrate Binding Kinetics
- Pearce F. Grant,Sprissler Clara,Gerrard Juliet A.
- The journal of biochemistry 143(5), 617-623, 2008-05-01
- NAID 10024909781
- Characterization of the L-Lysine Biosynthetic Pathway in the Obligate Methylotroph Methylophilus methylotrophus
- Gunji Yoshiya,Tsujimoto Nobuharu,Shimaoka Megumi [他],OGAWA (MIYATA) Yuri,SUGIMOTO Shin-ichi,YASUEDA Hisashi
- Bioscience, biotechnology, and biochemistry 68(7), 1449-1460, 2004-07-23
- … AS1 was examined through characterization of the enzymes aspartokinase (AK), aspartsemialdehyde dehydrogenase, dihydrodipicolinate synthase (DDPS), dihydrodipicolinate reductase, and diaminopimelate decarboxylase. …
- NAID 10013519797
Related Links
- Dihydrodipicolinate Reductase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Dihydrodipicolinate Reductase Description of Dihydrodipicolinate ...
- The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. ... Nucleotide sequence and expression of the Escherichia coli dapB ...
★リンクテーブル★
[★]
- 英
- dihydrodipicolinate reductase
- 関
- ジヒドロジピコリン酸レダクターゼ
[★]
- 英
- dihydrodipicolinate reductase
- 関
- ジヒドロジピコリン酸還元酵素
[★]
- (酵素)還元酵素、レダクターゼ、リダクターゼ
- 関
- dehydrogenase、oxidase、oxidoreductase、reducing enzyme