dideoxythymidine

English Journal

Zidovudine-poly(L-lactic acid) solid dispersions with improved intestinal permeability prepared by supercritical antisolvent process.

Yoshida VM1, Balcão VM, Vila MM, Oliveira Júnior JM, Aranha N, Chaud MV, Gremião MP.
Journal of pharmaceutical sciences.J Pharm Sci.2015 May;104(5):1691-700. doi: 10.1002/jps.24377. Epub 2015 Feb 10.
A supercritical antisolvent (SAS) process for obtaining zidovudine-poly(L-lactic acid) (PLLA) solid dispersions (SDs) was used to attain a better intestinal permeation of this drug. A 3(2) factorial design was used, having as independent variables the ratio 3'-azido-2'3'-dideoxythymidine (AZT)-PLLA
PMID 25676038

Pertusati F1, McGuigan C, Serpi M.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].Curr Protoc Nucleic Acid Chem.2015 Mar 9;60:15.6.1-15.6.10. doi: 10.1002/0471142700.nc1506s60.
The use of pronucleotides to circumvent the well-known drawbacks of nucleotide analogs has played a significant role in the area of antiviral and anticancer drug delivery. Several motifs have been designed to mask the negative charges on the phosphorus moiety of either nucleoside monophosphates or n
PMID 25754890

Tipu HN1, Shabbir A2.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.J Coll Physicians Surg Pak.2015 Mar;25(3):210-5. doi: 03.2015/JCPSP.210215.
Sanger and coworkers introduced DNA sequencing in 1970s for the first time. It principally relied on termination of growing nucleotide chain when a dideoxythymidine triphosphate (ddTTP) was inserted in it. Detection of terminated sequences was done radiographically on Polyacrylamide Gel Electrophore
PMID 25772964

Role of Nucleotide Excision Repair or Base Excision Repair in Movement of Various n-Alkylated Bases, Investigated by the Comet Assay

Odajima Chihiro,Nakamura Takanori,Nakamura Maki,Miura Masanori,Yamasaki Kayoko,Honda Gisho,Kikuchi Yasuaki,Yamamoto Ayumi,Sasaki Yu F.
Genes and Environment 36(1), 10-16, 2014
… We have shown that the action of BER can be distinguished from that of NER by the enhancement of a comet-positive response by 2′,3′-dideoxythymidine (ddT). …
NAID 130004481210

Odajima Chihiro,Nakamura Takanori,Miura Masanori,Yamazaki Kayoko,Honda Gisho,Kikuchi Yasuaki,Yamamoto Ayumi,Sasaki Yu F.
Genes and Environment 35(2), 46-52, 2013
… In this study, we investigated how 2′,3′-dideoxythymidine (ddT) which is a precursor of DNA polymerase β inhibitor, 2′,3′-dideoxythymidine 5′-triphosphate (ddTTP), affects comet-tail formation. …
NAID 130004481202

An unusual phenotypic and genotypic expression in F2 generation following one stage zidovudine exposure during pregnancy and lactation- an experiment in mice

Rajlakshmi Chongtham,Roy Jagat Kumar,Rai Amit Kumar [他],BHATTACHARYYA Asima,PANDEY Bajarang Lal
Journal of toxicological sciences 37(1), 51-61, 2012-02-01
… Zidovudine (3'-Azido-2', 3'-dideoxythymidine, AZT, ZDV) is routinely used as one of the component of antiretroviral therapy to prevent transmission of the HIV infection from mother to child. …
NAID 10030037362