Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/26 19:52:57」(JST)

Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.

Uses[edit]

Diclofenamide is often used to treat therapy-resistant epilepsy.^[1]

^ "Diclofenamide in the treatment of therapy-resistant epilepsy.". PubMed. Retrieved 13 May 2013. |coauthors= requires |author= (help)

Tawil R, McDermott M, Brown R, Shapiro B, Ptacek L, McManis P, Dalakas M, Spector S, Mendell J, Hahn A, Griggs R (2000). "Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.". Ann Neurol 47 (1): 46–53. doi:10.1002/1531-8249(200001)47:1<46::AID-ANA9>3.0.CO;2-H. PMID 10632100.
Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S (1991). "[Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences]". Eisei Shikenjo Hokoku 109 (109): 148–50. PMID 1364383.

This antihypertensive-related article is a stub. You can help Wikipedia by expanding it.

Analysis of gene profiles in glioma cells identifies potential genes, miRNAs, and target sites of migratory cells.

Xue F1, Shen R, Chen X.
Tumori.Tumori.2015 May 1;0(0):0. doi: 10.5301/tj.5000226. [Epub ahead of print]
AIMS: To explore the potential molecular mechanisms involved in migratory glioma cells.METHODS: The gene expression profiles of GSE28167, employing human malignant glioma U251MG cells cultured on strictly aligned versus randomly oriented electrospun nanofibers of polycaprolactone, were downloaded fr
PMID 25953448

Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation.

Tricarico D1, Mele A, Calzolaro S, Cannone G, Camerino GM, Dinardo MM, Latorre R, Conte Camerino D.
PloS one.PLoS One.2013 Jul 16;8(7):e69551. doi: 10.1371/journal.pone.0069551. Print 2013.
Emerging evidences suggest that Ca(2+)activated-K(+)-(BK) channel is involved in the regulation of cell viability. The changes of the cell viability observed under hyperkalemia (15 mEq/L) or hypokalemia (0.55 mEq/L) conditions were investigated in HEK293 cells expressing the hslo subunit (hslo-HEK29
PMID 23874973

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

Konstantopoulos N1, Molero JC, McGee SL, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta VC, Krippner G, Andrikopoulos S, Walder KR.
Diabetes.Diabetes.2012 Aug;61(8):2146-54. doi: 10.2337/db11-0578. Epub 2012 May 14.
We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro. The effects of these compounds were investigated in diabetic db/db mice, insulin-resistant diet-induced obese (DIO) mice, and rats with streptozot
PMID 22586591

リンク元	「dichlorphenamide」「ジクロフェナミド」

Diclofenamide
Systematic (IUPAC) name
	4,5-dichlorobenzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	55%
Identifiers
CAS number	120-97-8
ATC code	S01EC02
PubChem	CID 3038
DrugBank	DB01144
ChemSpider	2930
UNII	VVJ6673MHY
KEGG	D00518
ChEBI	CHEBI:101085
ChEMBL	CHEMBL17
Chemical data
Formula	C6H6Cl2N2O4S2
Mol. mass	305.16 g/mol
	SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N;
	InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) ; Key:GJQPMPFPNINLKP-UHFFFAOYSA-N ;
(what is this?) (verify);