English Journal

Minor enantiomer recycling: application to enantioselective syntheses of beta blockers.

Wen YQ1, Hertzberg R, Gonzalez I, Moberg C.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2014 Mar 24;20(13):3806-12. doi: 10.1002/chem.201303890. Epub 2014 Feb 26.
Continuous recycling of the minor product enantiomer obtained from the acetylcyanation of prochiral aldehydes provided access to highly enantiomerically enriched products. Cyanohydrin derivatives, which under normal conditions are obtained with modest or poor enantiomeric ratios, were formed with hi
PMID 24574310

Functional selectivity of G-protein-coupled receptors: from recombinant systems to native human cells.

Seifert R1.
Biochemical pharmacology.Biochem Pharmacol.2013 Oct 1;86(7):853-61. doi: 10.1016/j.bcp.2013.07.029. Epub 2013 Aug 8.
In the mid 1990s, it was assumed that a two-state model, postulating an inactive (R) state and an active (R*) state provides the molecular basis for GPCR activation. However, it became clear that this model could not accommodate many experimental observations. Accordingly, the two-state model was su
PMID 23933388

Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.

Brunskole Hummel I1, Reinartz MT, Kälble S, Burhenne H, Schwede F, Buschauer A, Seifert R.
PloS one.PLoS One.2013 May 31;8(5):e64556. doi: 10.1371/journal.pone.0064556. Print 2013.
In neutrophils, activation of the β2-adrenergic receptor (β2AR), a Gs-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various β2AR ligands on adenosine-3',5'-cyclic monophosphate (cAMP) accumulation
PMID 23741338

Japanese Journal

Binding Characteristics of [^3H] Dihydroalprenolol to β-Adrenergic Receptors of Rat Brain : Comparison with Those of Rat Heart Treated with Neuraminidase

土橋洋史,佐々木正憲,長友孝文
Chemical & pharmaceutical bulletin 33(9), 3972-3976, 1985-09-25
… dichloroisoproterenol > …
NAID 110003625929

EFFECTS OF PERHEXILINE ON MYOCARDIAL PHOSPHORYLASE ACTIVITY, MYOCARDIAL CATECHOLAMINE CONTENT AND HEART RATE

Okabe Eiichiro [他],HIGASHI HIROSHI,FUJISAWA TSUTOMU,CHO YOUNG W.,ITO HARUO
Japanese circulation journal 45(6), 667-671, 1981-06-20
… 3) Though slightly different from propranolol and dichloroisoproterenol, perhexiline possesses cardiac effects resembling β-blockers. …
NAID 110002582188

STUDY ON THE PHARMACOLOGICAL ACTIONS OF β-ADRENOCEPTOR BLOCKERS WITH REFERENCE TO THEIR PHYSICO-CHEMICAL PROPERTIES

HACHISU MITSUGU,KOEDA TAKEMI
Journal of pharmacobio-dynamics 3(4), 183-190, 1980-04
… dichloroisoproterenol (DCI) > …
NAID 110003635828

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