English Journal

Type II Intramolecular [5+2] Cycloaddition: Facile Synthesis of Highly Functionalized Bridged Ring Systems.

Mei G1, Liu X, Qiao C, Chen W, Li CC.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2014 Dec 10. doi: 10.1002/anie.201410806. [Epub ahead of print]
A type II intramolecular oxidopyrylium-mediated [5+2] cycloaddition reaction allows the efficient and diastereoselective formation of various highly functionalized and synthetically challenging bridged seven-membered ring systems (such as bicyclo[4.4.1]undecane, bicyclo[4.3.1]decane, bicyclo[5.4.1]d
PMID 25504815

Chiroptical detection of nonchromophoric, achiral guests by enantiopure alleno-acetylenic helicages.

Gidron O1, Ebert MO, Trapp N, Diederich F.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2014 Dec 1;53(49):13614-8. doi: 10.1002/anie.201406585. Epub 2014 Nov 10.
Enantiopure alleno-acetylenic ligands assemble diastereoselectively upon the addition of a zinc(II) salt to form triple-stranded helicates, which provide a sufficiently large helical cage ("helicage") for the encapsulation of guests. The inclusion complexation of heteroalicycles is confirmed by ROES
PMID 25384621

Romanov-Michailidis F1, Pupier M, Besnard C, Bürgi T, Alexakis A.
Organic letters.Org Lett.2014 Oct 3;16(19):4988-91. doi: 10.1021/ol5022355. Epub 2014 Sep 12.
An efficient and highly stereoselective fluorinative aza-semipinacol rearrangement is described. The catalytic reaction requires use of Selectfluor in combination with the chiral, enantiopure phosphate anion derived from acid L3. Under optimized conditions, cyclopropylamines A were transformed into
PMID 25215413