デキストロチロキシン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/24 15:47:07」(JST)
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Dextrothyroxine
|
| Clinical data |
| Trade names |
Choloxin |
| AHFS/Drugs.com |
Multum Consumer Information |
Pregnancy
category |
- US: B (No risk in non-human studies)
|
| ATC code |
C10AX01 (WHO) |
| Legal status |
| Legal status |
|
| Identifiers |
| CAS Number |
51-49-0 |
| PubChem |
CID 8730 |
| DrugBank |
DB00509 |
| ChemSpider |
8402 |
| UNII |
4W9K63FION |
| ChEBI |
CHEBI:30659 |
| ChEMBL |
CHEMBL559 |
| Synonyms |
D-3,5,3',5'-tetraiodothyronine |
| Chemical and physical data |
|
Systematic (IUPAC) name: (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
|
| 3D model (Jmol) |
Interactive image |
| Formula |
C15H11I4NO4 |
| Molar mass |
776.87 g/mol |
SMILES
-
O=C(O)[C@H](N)Cc2cc(I)c(Oc1cc(I)c(O)c(I)c1)c(I)c2
|
InChI
-
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
-
Key:XUIIKFGFIJCVMT-GFCCVEGCSA-N
|
Dextrothyroxine (trade name Choloxin) saw research as a cholesterol-lowering drug[1][2] but was pulled due to cardiac side-effects. It also increases hepatic lipase which in turn improves utilization of triglycerides, improving apolipoprotein E cholesterol particles.[citation needed]
See also
References
- ^ Bantle, J. P.; Hunninghake, D. B.; Frantz, I. D.; Kuba, K.; Mariash, C. N.; Oppenheimer, J. H. (1984). "Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia". The American Journal of Medicine. 77 (3): 475–481. doi:10.1016/0002-9343(84)90107-4. PMID 6475988.
- ^ Bommer, C.; Werle, E.; Walter-Sack, I.; Keller, C.; Gehlen, F.; Wanner, C.; Nauck, M.; März, W.; Wieland, H.; Bommer, J. (1998). "D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients". Journal of the American Society of Nephrology : JASN. 9 (1): 90–96. PMID 9440092.
|
Lipid modifying agents (C10)
|
|
| GI tract |
| Cholesterol absorption inhibitors, NPC1L1 |
|
|
| Bile acid sequestrants/resins (LDL) |
- Colestyramine
- Colestipol
- Colestilan
- Colextran
- Colesevelam
|
|
|
| Liver |
| Statins (HMG-CoA reductase, LDL) |
- Simvastatin#
- Atorvastatin
- Fluvastatin
- Lovastatin
- Mevastatin
- Pitavastatin
- Pravastatin
- Rosuvastatin
- Cerivastatin‡
|
|
| Niacin and derivatives (HDL and LDL) |
- Niceritrol
- Niacin
- Nicofuranose
- Aluminium nicotinate
- Nicotinyl alcohol
- Acipimox
|
|
| MTTP inhibitors (VLDL) |
- Dirlotapide
- Lomitapide
- Mitratapide
|
|
|
| Blood vessels |
| Fibrates (PPAR) |
- Clofibrate‡
- Bezafibrate
- Aluminium clofibrate
- Gemfibrozil
- Fenofibrate
- Simfibrate
- Ronifibrate
- Ciprofibrate
- Etofibrate
- Clofibride
- Clinofibrate
|
|
| CETP inhibitors (HDL) |
- Anacetrapib†
- Dalcetrapib§
- Evacetrapib§
- Torcetrapib§
|
|
|
| Combinations |
- Niacin/lovastatin
- Niacin/simvastatin
- Ezetimibe/simvastatin
- Ezetimibe/atorvastatin
- Niacin/laropiprant
|
|
| Other |
- Dextrothyroxine‡
- Probucol
- Tiadenol
- Benfluorex
- Meglutol
- Omega-3-triglycerides
- Magnesium pyridoxal 5-phosphate glutamate
- Policosanol
- Lapaquistat§
- Mipomersen
- Alipogene tiparvovec
- Triparanol
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
English Journal
- Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.
- Unüvar T1, Anık A, Catlı G, Esen I, Abacı A, Büyükgebiz A, Böber E.
- Journal of endocrinological investigation.J Endocrinol Invest.2014 Sep;37(9):799-804. doi: 10.1007/s40618-014-0100-y. Epub 2014 Jun 12.
- PURPOSE: The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters.METHODS: Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of
- PMID 24920280
- Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat.
- Kundu S1, Pramanik M, Roy S, De J, Biswas A, Ray AK.
- Life sciences.Life Sci.2006 Sep 5;79(15):1450-5. Epub 2006 Apr 25.
- Thyroid hormones are essential for normal functioning of adult mammalian brain. The present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat brain. Animals were rendered hypothyroid by PTU injections (2 mg/100 g bw) for 30 consecutive days. Se
- PMID 16698041
- The elemental importance of sufficient iodine intake: a trace is not enough.
- Visser TJ1.
- Endocrinology.Endocrinology.2006 May;147(5):2095-7.
- PMID 16617153
Related Links
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- Read more about the pharmacogenomics of dextrothyroxine on PharmGKB. ... Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the ...