dexibuprofen

Dexibuprofen
Systematic (IUPAC) name
	(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Identifiers
CAS Number	51146-56-6
ATC code	M01AE14 (WHO)
PubChem	CID 39912
ChemSpider	36498
UNII	671DKG7P5S
KEGG	D03715
ChEBI	CHEBI:43415
ChEMBL	CHEMBL175
Chemical data
Formula	C13H18O2
Molar mass	206.28082 g/mol
	SMILES C[C@@H](c1ccc(cc1)CC(C)C)C(=O)O ;
	InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1 ; Key:HEFNNWSXXWATRW-JTQLQIEISA-N ;
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デクスイブプロフェン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/10 21:48:09」(JST)

wiki en

[Wiki en表示]

Dexibuprofen is a non-steroidal anti-inflammatory drug. It is the active dextrorotatory enantiomer of ibuprofen.^[1] Most ibuprofen formulations contain a racemic mixture of both isomers.

References

^ Hardikar MS (2008). "Chiral non-steroidal anti-inflammatory drugs--a review". J Indian Med Assoc 106 (9): 615–8, 622, 624. PMID 19552094.

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English Journal

Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids.

Rasheed A, Kumar CK, Mishra A.SourceDepartment of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati, Andhra Pradesh, India.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2011 Oct;26(5):688-95. Epub 2011 Jan 21.
The present investigation deals with the synthesis of novel prodrugs of dexibuprofen with amino acids with an aim to achieve potent anti-inflammatory activity and less gastrointestinal toxicity. Structures of synthesized compounds were confirmed by spectral and elemental analyses. In vitro hydrolyti
PMID 21250819

Single dose oral analgesics for acute postoperative pain in adults.

Moore RA, Derry S, McQuay HJ, Wiffen PJ.SourcePain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, UK, OX3 7LJ.
Cochrane database of systematic reviews (Online).Cochrane Database Syst Rev.2011 Sep 7;9:CD008659.
BACKGROUND: Thirty-five Cochrane Reviews of randomised trials testing the analgesic efficacy of individual drug interventions in acute postoperative pain have been published. This overview brings together the results of all those reviews and assesses the reliability of available data.OBJECTIVES: To
PMID 21901726