Mass spectrometric detection of CYP450 adducts following oxidative desulfuration of methyl parathion.
Kyle PB, Smith SV, Baker RC, Kramer RE.SourceDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA. pkyle@umc.edu
Journal of applied toxicology : JAT.J Appl Toxicol.2013 Jul;33(7):644-51. doi: 10.1002/jat.1792. Epub 2012 Jan 23.
Cytochrome P450 (CYP)-mediated desulfuration of methyl parathion results in mechanism-based inhibition of the enzyme. Although previous data suggest that reactive sulfur is released and binds to the apoprotein, the identities of neither the adduct(s) nor the affected amino acid(s) have been clearly
Enzymology of H2S Biogenesis, Decay and Signaling.
Kabil O, Banerjee R.SourceDepartment of Biological Chemistry, University of Michigan Medical School , Ann Arbor, Michigan.
Antioxidants & redox signaling.Antioxid Redox Signal.2013 Jun 7. [Epub ahead of print]
Abstract Significance: Hydrogen sulfide (H2S), produced by the desulfuration of cysteine or homocysteine, functions as a signaling molecule in an array of physiological processes including regulation of vascular tone, the cellular stress response, apoptosis, and inflammation. Recent Advances: The lo
Chronic, low-level exposure to metals is an increasing global problem. Lead is an environmentally persistent toxin that causes many lead-related pathologies, directly affects tissues and cellular components or exerts an effect of the generation of reactive oxygen species causing a diminished level o