関: actin depolymerizing factor

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/21 20:23:38」(JST)

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Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene.^[2]^[3]^[4] Destrin is a component protein in microfilaments.

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.^[2]

Structure

The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, NMR.^[1] The secondary and tertiary structures of destrin are similar to the gelsolin family which is another actin-regulating protein family.

There are three ordered layers to destrin which is a globular protein. There is a central β sheet that is composed of one parallel strand and three antiparallel strands. This β sheet is between a long α helix along with a shorter one and two shorter helices on the opposite side. The four helices are parallel to the β strands.^[1]

Function

In a variety of eukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments. ^[1]

References

^ ^a ^b ^c ^d PDB 1AK6; Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F (June 1996). "Tertiary structure of destrin and structural similarity between two actin-regulating protein families". Cell 85 (7): 1047–55. doi:10.1016/S0092-8674(00)81305-7. PMID 8674111.
^ ^a ^b "Entrez Gene: Destrin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11034.
^ Hawkins M, Pope B, Maciver SK, Weeds AG (September 1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry 32 (38): 9985–93. doi:10.1021/bi00089a014. PMID 8399167.
^ Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

External links

Destrin at the US National Library of Medicine Medical Subject Headings (MeSH)
Ramachandran Plot for destrin: "MolProbity Ramachandran analysis for 1ak6". www.rcsb.org. http://www.rcsb.org/pdb/images/1AK6_ram_m_500.pdf.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 20 is a stub. You can help Wikipedia by expanding it.

English Journal

Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.

Su J1,2, Zhou Y3, Pan Z4, Shi L2, Yang J2, Liao A4, Liao Q3, Su Q2.
Scientific reports.Sci Rep.2017 Mar 30;7:45624. doi: 10.1038/srep45624.
PMID 28358024

Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.

Huo Y1, Xie X1, Jiang B2.
Molecular medicine reports.Mol Med Rep.2017 Jan;15(1):139-145. doi: 10.3892/mmr.2016.5984. Epub 2016 Dec 5.
PMID 27922676

Nucleus-associated actin in Amoeba proteus.

Berdieva M1, Bogolyubov D2, Podlipaeva Y2, Goodkov A2.
European journal of protistology.Eur J Protistol.2016 Oct;56:191-199. doi: 10.1016/j.ejop.2016.09.002. Epub 2016 Sep 9.
PMID 27684042

Japanese Journal

A Proteomic Study of S-Nitrosylation in the Rat Cardiac Proteins in Vitro

Biological & pharmaceutical bulletin 31(8), 1536-1540, 2008-08-01
NAID 110006839014

Rho情報伝達経路とその生理的意義

日本薬理学雑誌 121(3), 153-162, 2003-03-01
NAID 130000086201

Actin調節タンパク質destrinのactin脱重合活性に重要な領域

生物物理 43(supplement), S155, 2003
NAID 110001158255

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リンク元	「actin depolymerizing factor」

「actin depolymerizing factor」

Destrin (actin binding protein)
	Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.
Identifiers
Symbol	DSTN
Alt. symbols	ADF
Entrez	11034
HUGO	15750
OMIM	609114
RefSeq	NM_006870
UniProt	P60981
Other data
Locus	Chr. 20 p12.1

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アクチン脱重合因子

関: cofilin、destrin

[pmid8674111-1] PDB 1AK6; Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F (June 1996). "Tertiary structure of destrin and structural similarity between two actin-regulating protein families". Cell 85 (7): 1047–55. doi:10.1016/S0092-8674(00)81305-7. PMID 8674111.

[entrez-2] "Entrez Gene: Destrin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11034.

[pmid8399167-3] Hawkins M, Pope B, Maciver SK, Weeds AG (September 1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry 32 (38): 9985–93. doi:10.1021/bi00089a014. PMID 8399167.

[pmid11780052-4] Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

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destrin