デストリン
- 関
- actin depolymerizing factor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/03/21 20:23:38」(JST)
[Wiki en表示]
Destrin (actin binding protein) |
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Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.[1] |
Identifiers |
Symbol |
DSTN |
Alt. symbols |
ADF |
Entrez |
11034 |
HUGO |
15750 |
OMIM |
609114 |
RefSeq |
NM_006870 |
UniProt |
P60981 |
Other data |
Locus |
Chr. 20 p12.1 |
Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene.[2][3][4] Destrin is a component protein in microfilaments.
The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
Contents
- 1 Structure
- 2 Function
- 3 References
- 4 External links
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Structure
The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, NMR.[1] The secondary and tertiary structures of destrin are similar to the gelsolin family which is another actin-regulating protein family.
There are three ordered layers to destrin which is a globular protein. There is a central β sheet that is composed of one parallel strand and three antiparallel strands. This β sheet is between a long α helix along with a shorter one and two shorter helices on the opposite side. The four helices are parallel to the β strands.[1]
Function
In a variety of eukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments. [1]
References
- ^ a b c d PDB 1AK6; Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F (June 1996). "Tertiary structure of destrin and structural similarity between two actin-regulating protein families". Cell 85 (7): 1047–55. doi:10.1016/S0092-8674(00)81305-7. PMID 8674111.
- ^ a b "Entrez Gene: Destrin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11034.
- ^ Hawkins M, Pope B, Maciver SK, Weeds AG (September 1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry 32 (38): 9985–93. doi:10.1021/bi00089a014. PMID 8399167.
- ^ Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
External links
- Destrin at the US National Library of Medicine Medical Subject Headings (MeSH)
- Ramachandran Plot for destrin: "MolProbity Ramachandran analysis for 1ak6". www.rcsb.org. http://www.rcsb.org/pdb/images/1AK6_ram_m_500.pdf.
Proteins of the cytoskeleton
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Human |
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Nonhuman |
- Major sperm proteins
- Prokaryotic cytoskeleton
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See also: cytoskeletal defects B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
English Journal
- Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.
- Su J1,2, Zhou Y3, Pan Z4, Shi L2, Yang J2, Liao A4, Liao Q3, Su Q2.
- Scientific reports.Sci Rep.2017 Mar 30;7:45624. doi: 10.1038/srep45624.
- PMID 28358024
- Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.
- Huo Y1, Xie X1, Jiang B2.
- Molecular medicine reports.Mol Med Rep.2017 Jan;15(1):139-145. doi: 10.3892/mmr.2016.5984. Epub 2016 Dec 5.
- PMID 27922676
- Nucleus-associated actin in Amoeba proteus.
- Berdieva M1, Bogolyubov D2, Podlipaeva Y2, Goodkov A2.
- European journal of protistology.Eur J Protistol.2016 Oct;56:191-199. doi: 10.1016/j.ejop.2016.09.002. Epub 2016 Sep 9.
- PMID 27684042
Japanese Journal
- A Proteomic Study of S-Nitrosylation in the Rat Cardiac Proteins in Vitro
- Actin調節タンパク質destrinのactin脱重合活性に重要な領域
Related Links
- The latest Tweets from Destrin (@Destrin): "Turns out I last updated my PC in 2009. Actually will need to read shit to work out what GPU I could possible cram into it"
- Definition of destrin in the Definitions.net dictionary. Meaning of destrin. What does destrin mean? Information and translations of destrin in the most comprehensive dictionary definitions resource on the web.
★リンクテーブル★
[★]
- 関
- cofilin、destrin