English Journal
- Inhibition by beta-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes.
- Di Sotto A1, Mazzanti G, Carbone F, Hrelia P, Maffei F.Author information 1Department of Physiology and Pharmacology, Sapienza University, 00185 Rome, Italy.Abstractbeta-Caryophyllene is a bi-cyclic sesquiterpene that occurs in essential oils from several plants. A variety of biological activities have been ascribed to this compound. In particular, it seems to possess anti-carcinogenic properties, due to its capability to induce detoxifying enzymes or to enhance, in vitro and in vivo, the natural killer cell-induced cytotoxicity against tumours. Conversely, the knowledge on the DNA-damaging activity of the substance and its modulation is scanty. Therefore, in this study, we aimed at evaluating the capability of beta-caryophyllene to protect cultured human lymphocytes from the genotoxic damage induced by ethyl methanesulfonate (EMS) and colcemid (COL) in the micronucleus assay. To investigate the mechanisms of action of this sesquiterpene, the cultures were treated with the compound before (pre-treatment), during (co-treatment) and after (post-treatment) treatment with the mutagens. Up to 100 microg/ml, beta-caryophyllene by itself did not produce any cytotoxic and genotoxic effect, as shown by the value of the nuclear division index (NDI) and the frequency of micronuclei (MN). The test compound (0.1-100 microg/ml) significantly reduced the MN frequency induced by EMS in pre- and co-treatment protocols (up to 64.4% and 87% reduction, respectively). In the post-treatment protocol, beta-caryophyllene was not effective as an antimutagen. No significant reduction of COL-induced MN frequency was found. The antigenotoxic activity of beta-caryophyllene observed here suggests that this compound could act by chemical interaction with the mutagen in the growth medium (co-treatment) or in the cytoplasm of lymphocytes (pre-treatment), so acting as a desmutagen. These data encourage further studies to investigate the mode of action and the potential use of this compound as a chemopreventive agent.
- Mutation research.Mutat Res.2010 Jun 17;699(1-2):23-8. doi: 10.1016/j.mrgentox.2010.04.008. Epub 2010 Apr 14.
- beta-Caryophyllene is a bi-cyclic sesquiterpene that occurs in essential oils from several plants. A variety of biological activities have been ascribed to this compound. In particular, it seems to possess anti-carcinogenic properties, due to its capability to induce detoxifying enzymes or to enhanc
- PMID 20398787
- Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster.
- Patenkovic A1, Stamenkovic-Radak M, Banjanac T, Andjelkovic M.Author information 1Institute of Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11000 Belgrade, Serbia.AbstractThe present study assayed the antimutagenic potential of Salvia officinalis (sage) in the form of tea infusion, by the somatic mutation and recombination test (SMART) on Drosophila melanogaster. The use of herbal infusions is much common in the human diet, so the aim of the present study was to estimate the antimutagenic effects of the S. officinalis tea rather than essential oils. Methyl methanesulphonate (MMS) was used as the mutagen and positive control. Several types of treatment were performed: short acute treatment with sage infusion or MMS, longer (chronic) treatment with sage solution or MMS, and two combined treatments, i.e. short treatment with sage followed by a longer treatment with MMS and vice versa. Sage infusion used in our experiments showed a clear antimutagenic effect, reducing the frequency of mutations induced by MMS. The inhibition effect of sage tea is obtained and confirmed when pre- or post-treatments with mutagen were used. The results indicate that although sage in this regime decreases the number of mutation events, it is not efficient enough in case of the 2 h sage pre-treatment. Antioxidant activity, suppression of metabolic activation, could be mechanisms through which sage or some of its components act as desmutagen.
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2009 Jan;47(1):180-3. doi: 10.1016/j.fct.2008.10.024. Epub 2008 Nov 3.
- The present study assayed the antimutagenic potential of Salvia officinalis (sage) in the form of tea infusion, by the somatic mutation and recombination test (SMART) on Drosophila melanogaster. The use of herbal infusions is much common in the human diet, so the aim of the present study was to esti
- PMID 19022328
- Antimutagenic activity against trp-P-1 of the edible Thai plant, Oroxylum indicum vent.
- Nakahara K1, Onishi-Kameyama M, Ono H, Yoshida M, Trakoontivakorn G.Author information 1Japan International Research Center for Agricultural Sciences (JIRCAS), Tsukuba, Ibaraki. knakahar@affrc.go.jpAbstractA methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78+/-0.15 microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+/-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.
- Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2001 Oct;65(10):2358-60.
- A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78+/-0.15 microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+/-0
- PMID 11758941
Japanese Journal
- Antimutagenic Activity against Trp-P-1 of the Edible Thai Plant, Oroxylum indicum Vent.(Food & Nutrition Science)
- Nakahara Kazuhiko,Onishi-Kameyama Mayumi,Ono Hiroshi [他],YOSHIDA Mitsuru,TRAKOONTIVAKORN Gassinee
- Bioscience, biotechnology, and biochemistry 65(10), 2358-2360, 2001-10-23
- … Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2. …
- NAID 110002693292
- Antimutagenicity of Flavones and Flavonols to Heterocyclic Amines by Specific and Strong Inhibition of the Cytochrome P450 1A Family
- Kanazawa Kazuki,Yamashita Takatoshi,Ashida Hitoshi [他],DANNO Genichi
- Bioscience, biotechnology, and biochemistry 62(5), 970-977, 1998-05-23
- … We had previously found flavonoids to be a desmutagen to neutralize Trp-P-2 before or during attack of DNA, because they had no effect on either the ultimate mutagenic form of Trp-P-2 (N-hydroxy-Trp-P-2) or the mutated cells. …
- NAID 110002691924
- 小原 章裕,竹原 学
- 日本栄養・食糧学会誌 : Nippon eiyo shokuryo gakkaishi = Journal of Japanese Society of Nutrition and Food Science 50(5), 372-374, 1997-10-10
- Several tannins such as (+) -catechin, (-) -epicatechin and penta-O-galloyl glucose (PGG) have been well characterized as antimutagens or anticarcinogens in previous studies. The present studies were …
- NAID 10009283774
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