Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/13 02:27:26」(JST)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Neonicotinoid formaldehyde generators: Possible mechanism of mouse-specific hepatotoxicity/hepatocarcinogenicity of thiamethoxam.

Swenson TL, Casida JE.SourceEnvironmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, United States.
Toxicology letters.Toxicol Lett.2013 Feb 4;216(2-3):139-45. doi: 10.1016/j.toxlet.2012.11.027. Epub 2012 Dec 7.
Thiamethoxam (TMX), an important insecticide, is hepatotoxic and hepatocarcinogenic in mice but not rats. Studies of Syngenta Central Toxicology Laboratory on species specificity in metabolism established that TMX is a much better substrate for mouse liver microsomal CYPs than the corresponding rat
PMID 23220038

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

Mann S, Eveleigh L, Lequin O, Ploux O.SourceLaboratoire Charles Friedel, Chimie ParisTech ENSCP, 75231 Paris Cedex 05, France; CNRS, UMR 7223, 75005 Paris, France. Electronic address: stephane-mann@chimie-paristech.fr.
Analytical biochemistry.Anal Biochem.2013 Jan 15;432(2):90-6. doi: 10.1016/j.ab.2012.09.038. Epub 2012 Oct 12.
7,8-Diaminopelargonic acid (DAPA) aminotransferase is an enzyme of the biotin biosynthetic pathway that plays an essential role in Mycobacterium tuberculosis virulence. Inhibition of this enzyme is a potential strategy to combat this microorganism, the causative agent of tuberculosis. To identify ne
PMID 23068037

The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P-Receptor Functions Expressed in Xenopus Oocytes

MINAMI Kouichiro,YOKOYAMA Toru,OGATA Junichi,UEZONO Yasuhito
Journal of pharmacological sciences 115(3), 421-424, 2011-03-20
… <I>O</I>-Desmethyl tramadol (ODT) is one of the main metabolites of tramadol, having much greater analgesic potency than tramadol itself. …
NAID 10029892983

11C-Labeled Analogs of Indomethacin Esters and Amides for Brain Cyclooxygenase-2 Imaging: Radiosynthesis, in Vitro Evaluation and in Vivo Characteristics in Mice

Yamamoto Yumi,Toyohara Jun,Ishiwata Kiichi,Sano Kohei,Yamamoto Fumihiko,Mukai Takahiro,Maeda Minoru
Chemical and Pharmaceutical Bulletin 59(8), 938-946, 2011
… Five 11C-labeled COX-2 inhibitors, with different lipophilicities and moderate COX-2 inhibitory activity, were prepared by treatment of the corresponding O-desmethyl precursors with [11C]methyl triflate and purified by HPLC (radiochemical yields of 55—71%, radiochemical purity of >93%, and the specific activities of 22—331 GBq/μmol). …
NAID 130000960923