- 関
- dequalinium
WordNet
- any compound containing a chlorine atom
- any salt of hydrochloric acid (containing the chloride ion)
PrepTutorEJDIC
- 塩化物
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/27 15:14:52」(JST)
[Wiki en表示]
Dequalinium chloride
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Names |
IUPAC name
1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
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Identifiers |
ATC code |
D08AH01
G01AC05, R02AA02 |
ChEBI |
CHEBI:31466 N |
ChEMBL |
ChEMBL333826 N
ChEMBL121663 Y |
ChemSpider |
2886 Y |
DrugBank |
DB04209 Y |
InChI
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InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 Y
Key: PCSWXVJAIHCTMO-UHFFFAOYSA-P Y
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InChI=1/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
Key: PCSWXVJAIHCTMO-SKRXCDHZAO
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IUPHAR/BPS
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2313 |
Jmol-3D images |
Image |
MeSH |
Dequalinium |
PubChem |
10649 |
SMILES
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c12ccccc1c(cc([n+]2CCCCCCCCCC[n+]4c3ccccc3c(N)cc4C)C)N
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UNII |
E7QC7V26B8 Y |
Properties |
Chemical formula
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C30H40Cl2N4 |
Molar mass |
527.58 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) |
Infobox references |
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Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications:
Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration.
Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis).
The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by a dodecylene chain.
Contents
- 1 Applications
- 2 References
- 3 Further reading
- 4 External links
Applications
Dequalinium salts may be used to treat malaria.[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections [2]
References
- ^ "US Patent 4946849". United States Patents and Trademarks Office (USPTO). 10 October 1989. Retrieved 2008-03-15.
- ^ Krämer W. (1977). "[Treatment of tonsilitis with dequalinium chloride]". Fortschr Med. (in German) 95 (16): 1108–10. PMID 856702.
Further reading
- Gamboa-Vujicic, Gisela; Emma, Dennis A.; Liao, Shu Y.; Fuchtner, Carlos; Manetta, Alberto (1993). "Toxicity of the mitochondrial poison dequalinium chloride in a murine model system". Journal of Pharmaceutical Sciences 82 (3): 231–5. doi:10.1002/jps.2600820302. PMID 8450414.
External links
- International Mark - Fluomizin(804560)
- Medinova Fluomizin
- Comparative Study of Efficacy of 10 mg Dequalinium Chloride (Fluomizin) in the Local Treatment of Bacterial Vaginosis
Antiseptics and disinfectants (D08)
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Acridine derivatives |
- Ethacridine lactate
- 9-Aminoacridine
- Euflavine
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Biguanides and amidines |
- Dibrompropamidine
- Chlorhexidine#
- Propamidine
- Hexamidine
- Polihexanide
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Phenol and derivatives |
- Hexachlorophene
- Policresulen
- Phenol
- Triclosan
- Chloroxylenol#
- Biphenylol
- Fenticlor
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Nitrofuran derivatives |
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Iodine products |
- Iodine/octylphenoxypolyglycolether
- Povidone-iodine#
- Diiodohydroxypropane
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Quinoline derivatives |
- Dequalinium
- Chlorquinaldol
- Oxyquinoline
- Clioquinol
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Quaternary ammonium compounds |
- Benzalkonium
- Benzethonium chloride
- Cetrimonium (bromide/chloride)
- Cetylpyridinium
- Cetrimide
- Benzoxonium chloride
- Didecyldimethylammonium chloride
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Mercurial products |
- Mercuric amidochloride
- Phenylmercuric borate
- Mercuric chloride
- Merbromin
- Thiomersal
- Mercuric iodide
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Silver compounds |
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Alcohols |
- Propanol (propyl alcohol)
- Isopropanol (isopropyl alcohol)
- Ethanol (ethyl alcohol)#
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Other |
- Potassium permanganate
- Sodium hypochlorite
- Hydrogen peroxide
- Eosin
- Tosylchloramide
- Octenidine dihydrochloride
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of skin
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Description |
- Anatomy
- Physiology
- Development
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Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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Gynecological anti-infectives and antiseptics (G01)
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Antibiotics |
- Candicidin
- Chloramphenicol
- Hachimycin
- Oxytetracycline
- Carfecillin
- Mepartricin
- Clindamycin
- Pentamycin
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Arsenic compounds |
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Quinoline derivatives |
- Diiodohydroxyquinoline
- Clioquinol
- Chlorquinaldol
- Dequalinium
- Broxyquinoline
- Oxyquinoline
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Organic acids |
- Lactic acid
- Acetic acid
- Ascorbic acid
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Sulfonamides |
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Antifungals |
Imidazoles |
- Metronidazole
- Clotrimazole
- Miconazole
- Econazole
- Ornidazole
- Isoconazole
- Tioconazole
- Ketoconazole
- Fenticonazole
- Azanidazole
- Propenidazole
- Butoconazole
- Omoconazole
- Oxiconazole
- Flutrimazole
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Triazoles |
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Polyenes |
- Nystatin
- Natamycin
- Amphotericin B
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Other |
- Ciclopirox
- Methylrosaniline
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Other |
- Clodantoin
- Inosine
- Policresulen
- Nifuratel
- Furazolidone
- Povidone-iodine
- Protiofate
- Lactobacillus fermentum
- Copper usnate
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Index of reproductive medicine
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Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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UpToDate Contents
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English Journal
- Raf/MEK/ERK signaling inhibition enhances the ability of dequalinium to induce apoptosis in the human leukemic cell line K562.
- Sancho P, Galeano E, Estañ MC, Gañán-Gómez I, Boyano-Adánez Mdel C, García-Pérez AI.SourceDepartamento de Bioquímica y Biología Molecular, Campus Universitario, Universidad de Alcalá, Madrid. pilar.sancho@uah.es
- Experimental biology and medicine (Maywood, N.J.).Exp Biol Med (Maywood).2012 Aug 1;237(8):933-42. doi: 10.1258/ebm.2012.011423. Epub 2012 Aug 8.
- Delocalized lipophilic cations, such as dequalinium (DQA), selectively accumulate in mitochondria and display anticancer activity in cells from different malignancies. Previous studies in K562 human leukemic cells indicate that DQA causes cell damage as a consequence of an early disturbance in the m
- PMID 22875343
- Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7.
- Chubanov V, Mederos y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T.SourceWalther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Munich, Germany. vladimir.chubanov@lrz.uni-muenchen.de
- British journal of pharmacology.Br J Pharmacol.2012 Jun;166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x.
- BACKGROUND AND PURPOSE: Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bifunctional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. TRPM7 is essential for proliferation and cell growth. Up-regulation of TRPM7 function is involve
- PMID 22242975
Japanese Journal
- Streptococcus sobrinus 6715株接種ラットにおける塩化デカリニウムおよび臭化ドミフェンのう蝕抑制効果
- う蝕病原菌の非水溶性グルカン合成に対する第4級アンモニウム塩類の抑制効果
Related Links
- Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications: Dequadin ...
- 18 Feb 2010 ... Dequadin lozenges contain the active ingredient dequalinium chloride, which is an antiseptic medicine. ... Dequalinium chloride has an antiseptic effect against a wide range of bacteria, yeasts, and some fungi and viruses.
★リンクテーブル★
[★]
- 英
- dequalinium
- 化
- 塩化デカリニウム dequalinium chloride
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デカリニウム
- 関
- dequalinium chloride
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