関: dGMP

WordNet

a nucleoside component of DNA; composed of guanine and deoxyribose (同)guanosine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/23 03:12:58」(JST)

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Deoxyguanosine monophosphate, also known as deoxyguanylate, or dGMP, is a derivative of the common nucleic acid guanosine triphosphate (GTP), in which the –OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been reduced to just a hydrogen atom (hence the "deoxy-" part of the name). It is used as a monomer in DNA.^[1]

References

^ Müller, Sabine (2008-09-08). Nucleic Acids from A to Z. John Wiley & Sons. ISBN 9783527622535.

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English Journal

Modeling the Conformational Preference of the Carbon-Bonded Covalent Adduct Formed upon Exposure of 2'-Deoxyguanosine to Ochratoxin A.

Sharma P, Manderville RA, Wetmore SD.SourceDepartment of Chemistry and Biochemistry, University of Lethbridge , 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
Chemical research in toxicology.Chem Res Toxicol.2013 May 20;26(5):803-16. doi: 10.1021/tx4000864. Epub 2013 Apr 23.
The conformational flexibility of the C8-linked guanine adduct formed from attachment of ochratoxin A (OTA) was analyzed using a systematic computational approach and models ranging from the nucleobase to the adducted DNA helix. A focus was placed on the influence of the C8-modification of 2'-deoxyg
PMID 23560542

Modification of DNA damage mechanisms by nitric oxide during ionizing radiation.

Folkes LK, O'Neill P.SourceGray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Free radical biology & medicine.Free Radic Biol Med.2013 May;58:14-25. doi: 10.1016/j.freeradbiomed.2013.01.014. Epub 2013 Jan 29.
Nitric oxide ((•)NO) is a very effective radiosensitizer of hypoxic mammalian cells. In vivo (•)NO may have effects on tumor vasculature and hence on tumor oxygenation and it may also interact with radiation-produced radicals to modify DNA lesions. Few studies have addressed this last aspect, an
PMID 23376236

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP).

Grabmann G, Keppler BK, Hartinger CG.SourceInstitute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090, Vienna, Austria.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2013 Apr 26. [Epub ahead of print]
The development of DNA-targeted next-generation platinum-based anticancer chemotherapeutics is often accompanied by studies on the reactivity to DNA models. However, the incubation conditions used in literature vary widely, and some of the buffer/salts used are known to form complexes with Pt. Such
PMID 23620371

Japanese Journal

Fast Repair Activities Towards dGMP Hydroxyl Radical Adducts by Silybin and its Analogues

Journal of radiation research 49(6), 609-614, 2008-11-16
NAID 110006985820

Oxidative damage in nucleic acids and Parkinson's disease.

Journal of Neuroscience Research 85(5), 919-934, 2007-04
NAID 120000985083

金基板上でのグアニン塩基の酸化電流に基づくDNA量の測定(<特集>生命科学と分析化学)

分析化学 55(12), 975-978, 2006-12-05
NAID 110004997512

「デオキシグアノシン一リン酸」

Deoxyguanosine monophosphate
Identifiers
CAS Number	902-04-5
ChEBI	CHEBI:16192
ChemSpider	58570
IUPHAR/BPS	5122
Jmol interactive 3D	Image
PubChem	65059
	InChI InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 Key: LTFMZDNNPPEQNG-KVQBGUIXSA-N ; InChI=1/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 Key: LTFMZDNNPPEQNG-KVQBGUIXBV ;
	SMILES C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3O)N)COP(=O)(O)O)O ;
Properties
Chemical formula	C10H14N5O7P
Molar mass	347.2243
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: deoxyguanosine monophosphate、dGMP
関: デオキシグアニル酸、2'-デオキシグアノシン-5'-リン酸、2'デオキシグアノシン5'一リン酸

「dGMP」

　　[★]

デオキシグアノシン一リン酸

関: 2'-deoxyguanosine 5'-monophosphate、2'-deoxyguanosine 5'-phosphate、deoxyguanosine monophosphate

「デオキシグアニル酸」

　　[★]

英: deoxyguanylic acid
同: デオキシグアノシン一リン酸 deoxyguanosine monophosphate

「monophosphate」

　　[★]

n.

一リン酸塩、一リン酸エステル、一リン酸

「deoxyguanosine」

　　[★]

デオキシグアノシン

関: dG

[1] Müller, Sabine (2008-09-08). Nucleic Acids from A to Z. John Wiley & Sons. ISBN 9783527622535.

リンク元	「デオキシグアノシン一リン酸」「dGMP」「デオキシグアニル酸」
関連記事	「monophosphate」「deoxyguanosine」

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案内

deoxyguanosine monophosphate