デオキシシチジンデアミナーゼ
WordNet
- a nucleoside component of DNA; composed of cytosine and deoxyribose (同)cytidine
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/02 15:46:21」(JST)
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| deoxycytidine deaminase |
| Identifiers |
| EC number |
3.5.4.5 |
| CAS number |
37259-56-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a deoxycytidine deaminase (EC 3.5.4.5) is an enzyme that catalyzes the chemical reaction
- deoxycytidine + H2O deoxyuridine + NH3
Thus, the two substrates of this enzyme are deoxycytidine and H2O, whereas its two products are deoxyuridine and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytidine/2'-deoxycytidine aminohydrolase. This enzyme participates in pyrimidine metabolism. As every deoxycytidine deaminase is also a cytidine deaminase, they share the same EC number. The recommended name assigned by the IUBMB is cytidine deaminase. [1]
References
- ^ "BRENDA: Information on EC 3.5.4.5 - cytidine deaminase".
- Cohen SS (1953). "Studies on controlling mechanisms in the metabolism of virus-infected bacteria". Cold Spring Harbour Symp. Quant. Biol. 18: 221–235.
UpToDate Contents
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English Journal
- AID and Apobec3G haphazard deamination and mutational diversity.
- Jaszczur M, Bertram JG, Pham P, Scharff MD, Goodman MF.SourceDepartments of Biological Sciences and Chemistry, Molecular and Computational Biology Section, University of Southern California, Los Angeles, CA, 90089-2910, USA.
- Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2012 Nov 22. [Epub ahead of print]
- Activation-induced deoxycytidine deaminase (AID) and Apobec 3G (Apo3G) cause mutational diversity by initiating mutations on regions of single-stranded (ss) DNA. Expressed in B cells, AID deaminates C → U in actively transcribed immunoglobulin (Ig) variable and switch regions to initiate the som
- PMID 23178850
- Trichoderma harzianum ETS 323-mediated resistance in Brassica oleracea var. capitata to Rhizoctonia solani involves the novel expression of a glutathione S-transferase and a deoxycytidine deaminase.
- Shibu MA, Lin HS, Yang HH, Peng KC.SourceDepartment of Life Science and the Institute of Biotechnology, National Dong Hwa University, Hualien, 97401, Taiwan (ROC).
- Journal of agricultural and food chemistry.J Agric Food Chem.2012 Oct 31;60(43):10723-32. doi: 10.1021/jf3025634. Epub 2012 Oct 19.
- Plant interactions with microbial biocontrol agents are used as experimental models to understand resistance-related molecular adaptations of plants. In a hydroponic three-way interaction study, a novel Trichoderma harzianum ETS 323 mediated mechanism was found to induce resistance to Rhizoctonia
- PMID 23046447
Japanese Journal
- Synthesis of Gemcitabine Analogues as Potential Anti-tumor Agents
- APOBEC3G targets human T-cell leukemia virus type 1.
- Antitumor activity of sugar-modified cytosine nucleosides
Related Links
- Deoxycytidine Triphosphate Deaminase: Identification and Function in Salmonella typhimurium J. Neuhard 1 and E. Thomassen 1 a Enzyme Division, University Institute of Biological Chemistry B, Copenhagen K, Denmark 1 3 ...
- Learn and talk about Deoxycytidine deaminase , and check out Deoxycytidine deaminase on Wikipedia, Youtube, Google News, Google ...
★リンクテーブル★
[★]
- 英
- deoxycytidine deaminase
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デオキシシチジン
- 関
- CdR、CDR、dC
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デアミナーゼ、脱アミノ酵素