demoxytocin

デモキシトシン

関

deaminooxytocin

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/07 08:30:47」(JST)

wiki en

[Wiki en表示]

Demoxytocin
IUPAC name 2-[(1-{[13-(butan-2-yl)-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl)formamido]-N-(carbamoylmethyl)-4-methylpentanamide
Identifiers
CAS number	113-78-0
PubChem	8229
KEGG	D07228 Y
MeSH	deaminooxytocin
ATC code	H01BB01
Jmol-3D images	Image 1
SMILES CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
Properties
Molecular formula	C43H65N11O12S2
Molar mass	992.17 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Demoxytocin (INN, trade name Sandopart) or deaminooxytocin, is an obstetric drug often^{[citation needed]} used in the prevention of puerperal mastitis. It is an analogue of oxytocin.

References

English Journal

• Time-resolved phosphorescence of tyrosine, tyrosine analogs, and tyrosyl residues in oxytocin and small peptides.

• Rousslang KW1, Reid PJ, Holloway DM, Haynes DR, Dragavon J, Ross JB.
• Journal of protein chemistry.J Protein Chem.2002 Nov;21(8):547-55.
• We present the time-resolved phosphorescence of oxytocin, two oxytocin derivatives, vasopressin and a series of compounds that serve as models for free tyrosine. One of the oxytocin derivatives, desaminodicarbaoxytocin, has the disulfide bridge replaced by an ethylene bridge, and lacks the N-terminu
• PMID 12638657

• Synthesis and pharmacology of novel analogues of oxytocin and deaminooxytocin: directed methods for the construction of disulfide and trisulfide bridges in peptides.

• Chen L1, Zoulíková I, Slaninová J, Barany G.
• Journal of medicinal chemistry.J Med Chem.1997 Mar 14;40(6):864-76.
• Using as models the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated. The linear sequences (through common octapeptide-resin intermediates) were assembled smoothly on tris(a
• PMID 9083475

• Syntheses and biological activities of parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin.

• Chen L1, Bauerová H, Slaninová J, Barany G.
• Peptide research.Pept Res.1996 May-Jun;9(3):114-21.
• New methods have been developed for the synthesis of disulfide-bridged homo and hetero peptide dimers (both parallel and antiparallel), as exemplified in the oxytocin and deamino-oxytocin families. The linear sequences were assembled by 9-fluorenyl-methyloxycarbonyl (Fmoc) solid-phase synthesis tech
• PMID 8875590

---

★リンクテーブル★

リンク元	「デモキシトシン」「deaminooxytocin」

「デモキシトシン」

　　[★]

英

demoxytocin

関

デアミノオキシトシン

「deaminooxytocin」

　　[★]

デアミノオキシトシン

関

demoxytocin