Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine.
Vanhoutte C, Goossens A, Gilissen L, Huygens S, Vital-Durand D, Dendooven E, Aerts O.
Contact dermatitis. 2019 Jul;81(1)17-23.
Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics, in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and the risk of subsequent iodine overdose. To rep
Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H receptor.
Frank A, Meza-Arriagada F, Salas CO, Espinosa-Bustos C, Stark H.
Bioorganic & medicinal chemistry. 2019 May;().
Inspired by marine compounds the derivatization of the natural pyrrolo[2,3-d]pyrimidine lead scaffold led to a series of novel compounds targeting the histamine H receptor. The focus was set on improved binding towards the receptor and to establish an initial structure-activity relationship for this
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-Catalysed Cross-Coupling Reactions between Organolithium Reagents and (Hetero)aryl Halides.
Angewandte Chemie (International ed. in English). 2019 Feb;58(6)1799-1802.
Direct palladium-catalysed cross-couplings between organolithium reagents and (hetero)aryl halides (Br, Cl) proceed fast, cleanly and selectively at room temperature in air, with water as the only reaction medium and in the presence of NaCl as a cheap additive. Under optimised reaction conditions, a
Total Conversion of Racemic 2-Chloropropionic Acid into D-Lactate by Combination of Enzymatic and Chemical Dehalogenations
HASAN A. K. M. QUAMRUL,MOTOSUGI KENZO,ESAKI NOBUYOSHI,SODA KENJI
Journal of fermentation and bioengineering 72(6), 481-482, 1991-12-25
… L-2-Chloropropionic acid is fully converted to D-lactic acid with L-2-halo acid dehalogenase, and the unreacted D-2-chloropropionic acid is dehalogenated chemically, retaining its configuration to produce D-latics acid. …
This invention relates to the partially dehalogenated reactive derivatives of the substantially fully saturated halogenation addition products of the aldehydes of the mono hetero atomic five membered rings as well as to the methods for ...