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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/23 18:13:09」(JST)
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Deoxycytidine triphosphate |
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Identifiers |
CAS number |
2056-98-6 Y |
PubChem |
65091 |
Jmol-3D images |
Image 1 |
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C1C(C(OC1N2C=CC(=NC2=O)N) COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
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Properties |
Molecular formula |
C9H16N3O13P3 |
Molar mass |
467.156923 |
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Infobox references |
Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. e.g.:
A chemical equation can be written that represents the process:
- (DNA)n + dCTP ↔ (DNA)n-C + PPi
That is, dCTP has the PPi (pyrophosphate) cleaved off and the dCMP is incorporated into the DNA strand at the 3' end. Subsequent hydrolysis of the PPi drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain.
It is stored at -20 degrees Celsius.[by whom?]
See also[edit]
Nucleic acid constituents
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Nucleobase |
Purine (Adenine, Guanine, Hypoxanthine, Xanthine, Purine analogue) · Pyrimidine (Uracil, Thymine, Cytosine, Pyrimidine analogue)
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Nucleoside |
Ribonucleoside
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Adenosine · Guanosine · 5-Methyluridine · Uridine · Cytidine · Inosine · Xanthosine
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Deoxyribonucleoside
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Deoxyadenosine · Deoxyguanosine · Thymidine · Deoxyuridine · Deoxycytidine · Deoxyinosine · Deoxyxanthosine
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Nucleotide
(Nucleoside monophosphate) |
Ribonucleotide
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AMP, GMP, m5UMP, UMP, CMP, IMP, XMP
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Deoxyribonucleotide
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dAMP, dGMP, dTMP, dUMP, dCMP, dIMP, dXMP
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Cyclic nucleotide
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cAMP, cGMP, c-di-GMP, cADPR
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Nucleoside diphosphate |
ADP, GDP, m5UDP, UDP, CDP
dADP, dGDP, dTDP, dUDP, dCDP
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Nucleoside triphosphate |
ATP, GTP, m5UTP, UTP, CTP, ITP, XTP
dATP, dGTP, dTTP, dUTP, dCTP, dITP, dXTP
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- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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English Journal
- Capacity of N4-methyl-2'-deoxycytidine 5'-triphosphate to sustain the polymerase chain reaction using various thermostable DNA polymerases.
- Flores-Juárez CR, González-Jasso E, Antaramian A, Pless RC.SourceCICATA, Instituto Politécnico Nacional, Querétaro, Querétaro 76090, Mexico.
- Analytical biochemistry.Anal Biochem.2013 Jul 1;438(1):73-81. doi: 10.1016/j.ab.2013.03.025. Epub 2013 Mar 30.
- The dCTP analog N4-methyl-2'-deoxycytidine 5'-triphosphate (N4medCTP) was evaluated for its performance in the polymerase chain reaction (PCR). Using the HotStart Taq DNA polymerase with a standard thermal protocol, test segments 85 or 200 bp long were amplified equally well using dCTP or N4medCTP:d
- PMID 23548504
- Insights into the Conformation of Aminofluorene-dG Adduct in a DNA Polymerase Active Site.
- Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP.SourceUniversity of Rhode Island, United States;
- The Journal of biological chemistry.J Biol Chem.2013 Jun 24. [Epub ahead of print]
- The active site conformation of the mutagenic fluoroaminofluorene-deoxyguanine adduct [dG-FAF, N-(2'-deoxyguanosin-8-yl)-7-fluoro-2-aminofluorene] have been investigated in the presence of Klenow fragment of E. coli DNA polymerase I (Kfexo-) and DNA polymerase beta (pol beta) using 19F NMR, insertio
- PMID 23798703
- Replication past the Butadiene Diepoxide-Derived DNA Adduct S-[4-(N(6)-Deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA Polymerases.
- Cho SH, Guengerich FP.SourceDepartment of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.
- Chemical research in toxicology.Chem Res Toxicol.2013 Jun 17;26(6):1005-13. doi: 10.1021/tx400145e. Epub 2013 Jun 4.
- 1,2,3,4-Diepoxybutane (DEB), a metabolite of the carcinogen butadiene, has been shown to cause glutathione (GSH)-dependent base substitution mutations, especially A:T to G:C mutations in Salmonella typhimurium TA1535 [Cho, S. H., et al. (2010) Chem. Res. Toxicol. 23, 1544] and Escherichia coli TRG8
- PMID 23701509
Japanese Journal
- Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos
- Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos
- DNA Polymerase λ Promotes Mutagenesis Induced by 8-Oxo-7, 8-dihydroguanine(8-hydroxyguanine)Paired with Adenine
- Genes and environment : the official journal of the Japanese Environmental Mutagen Society 35(4), 105-109, 2013-11-20
- NAID 10031196752
Related Pictures
★リンクテーブル★
[★]
- 英
- deoxycytidine 5'-triphosphate, dCTP
- 関
- デオキシリボヌクレオシド三リン酸
[★]
- 関
- CdR、deoxycytidine