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1. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の病因 nsaids including aspirin pathogenesis of gastroduodenal toxicity
2. 外傷に伴う凝固障害 coagulopathy associated with trauma
3. 急性食道壊死（急性壊死性食道炎） acute esophageal necrosis black esophagus
4. 心臓同種移植血管症の病因および危険因子 pathogenesis of and risk factors for cardiac allograft vasculopathy
5. 虚血性肝炎、肝梗塞、および虚血性胆管症 ischemic hepatitis hepatic infarction and ischemic cholangiopathy

English Journal

The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells.

Carlisi D1, Lauricella M, D'Anneo A, Buttitta G, Emanuele S, di Fiore R, Martinez R, Rolfo C, Vento R, Tesoriere G.
Journal of cellular physiology.J Cell Physiol.2015 Jun;230(6):1276-89. doi: 10.1002/jcp.24863.
The sesquiterpene lactone Parthenolide (PN) exerted a cytotoxic effect on MDA-MB231 cells, a triple-negative breast cancer (TNBC) cell line, but its effectiveness was scarce when employed at low doses. This represents an obstacle for a therapeutic utilization of PN. In order to overcome this difficu
PMID 25370819

Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells.

Lee MS1, Lee B2, Park KE1, Utsuki T3, Shin T4, Oh CW5, Kim HR6.
Food chemistry.Food Chem.2015 May 1;174:538-46. doi: 10.1016/j.foodchem.2014.11.090. Epub 2014 Nov 22.
Dieckol was previously reported to exhibit antioxidant and anticancer activities in vitro studies. In this study, we characterised the mechanism underlying the dieckol-mediated expression of antioxidant and detoxifying enzymes. Dieckol suppressed the production of intracellular reactive oxygen speci
PMID 25529716

Protective effect of Porphyra yezoensis glycoprotein on D-galactosamine‑induced cytotoxicity in Hepa 1c1c7 cells.

Choi JW1, Kim YM1, Park SJ1, Kim IH1, Nam TJ1.
Molecular medicine reports.Mol Med Rep.2015 May;11(5):3914-9. doi: 10.3892/mmr.2015.3244. Epub 2015 Jan 23.
The present study aimed to examine the signaling pathways and enzyme activity associated with the protective effect of Porphyra yezoensis glycoprotein (PYGP) on D‑galactosamine (D‑GaIN)‑induced cytotoxicity in Hepa 1c1c7 cells. D‑GaIN is commonly used to induce hepatic injury models in v
PMID 25626067

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

Tazawa Hiroshi,Kagawa Shunsuke,Fujiwara Toshiyoshi
Acta Medica Okayama 67(6), 333-342, 2013-12
… Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. …
NAID 120005353344

Effects of Biliverdin Administration on Acute Lung Injury Induced by Hemorrhagic Shock and Resuscitation in Rats

Kosaka Junko,Morimatsu Hiroshi,Takahashi Toru,Shimizu Hiroko,Kawanishi Susumu,Omori Emiko,Endo Yasumasa,Tamaki Naofumi,Morita Manabu,Morita Kiyoshi
PLoS ONE 8(5), 2013-05-07
… Biliverdin, a metabolite of heme catabolism, has been shown to have potent cytoprotective, anti-inflammatory, and anti-oxidant effects. …
NAID 120005359106