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1. 軟性下疳 chancroid
2. カンピロバクター感染の微生物学、病因、および疫学 microbiology pathogenesis and epidemiology of campylobacter infection

English Journal

Cellular interactions of the cytolethal distending toxins from escherichia coli and haemophilus ducreyi.

Gargi A, Tamilselvam B, Powers B, Prouty MG, Lincecum T, Eshraghi A, Maldonado-Arocho FJ, Wilson BA, Bradley KA, Blanke SR.SourceUniversity of Illinois at Urbana Champaign, United States;
The Journal of biological chemistry.J Biol Chem.2013 Jan 10. [Epub ahead of print]
The cytolethal distending toxins (CDTs) comprise a subclass of intracellular-acting genotoxins produced by many Gram-negative pathogenic bacteria that disrupt the normal progression of the eukaryotic cell cycle. Here, CDTs from Escherichia coli (Ec-CDT) and Haemophilus ducreyi (Hd-CDT), which share
PMID 23306199

Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response.

Guidi R, Guerra L, Levi L, Stenerlöw B, Fox JG, Josenhans C, Masucci MG, Frisan T.SourceDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Cellular microbiology.Cell Microbiol.2013 Jan;15(1):98-113. doi: 10.1111/cmi.12034. Epub 2012 Nov 1.
Epidemiological evidence links chronic bacterial infections to the increased incidence of certain types of cancer but the molecular mechanisms by which bacteria contribute to tumour initiation and progression are still poorly characterized. Here we show that chronic exposure to the genotoxin cytolet
PMID 22998585

From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.

Fedor Y, Vignard J, Nicolau-Travers ML, Boutet-Robinet E, Watrin C, Salles B, Mirey G.SourceINRA, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027, Toulouse, France.
Cellular microbiology.Cell Microbiol.2013 Jan;15(1):1-15. doi: 10.1111/cmi.12028. Epub 2012 Oct 9.
The Cytolethal Distending Toxin (CDT) is a genotoxin produced by several pathogenic bacteria. It is generally admitted that CDT induces double-strand breaks (DSB) and cell cycle arrest in G2/M-phase, in an ATM-dependent manner. Most of these results were obtained at high dose (over 1 μg ml(-1) )
PMID 22978660

A Cytolethal Distending Toxin Gene-Based Multiplex PCR Assay for Detection of Campylobacter spp. in Stool Specimens and Comparison with Culture Method

Evaluation of a cytolethal distending toxin (cdt) gene-based species-specific multiplex PCR assay for the identification of Campylobacter strains isolated from diarrheal patients in Japan