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an expanded petiole taking on the function of a leaf blade

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/18 21:47:02」(JST)

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Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and phylloides tumor, are typically large, fast-growing masses that form from the periductal stromal cells of the breast. They account for less than 1% of all breast neoplasms.

Classification

Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. They may be considered benign, borderline, or malignant depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and mitotic activity.^[1] All forms of phyllodes tumors are regarded as having malignant potential. A large series from the M.D. Anderson Cancer Centre reported the incidence of each as benign (58%), borderline (12%), and malignant (30%). Malignant phyllodes tumours behave like sarcomas and can develop blood-borne metastases. Approximately 10% of patients with phyllodes tumours develop distant metastases and this can go up to 20% in patients with histologically malignant tumours.^[2] The commonest sites for distant metastases are the lung, bone, and abdominal viscera. Rare sites of metastasis like to parotid region have also been described.^[3]

They are classified as a fibroepithelial tumor by ICD-O, but not by MeSH.

Women as young as 14 years old have developed the malignant form and it seems to be more aggressive in younger women.^[4]

Presentation

Phyllodes tumor in mammography

Anatomopathological results of phyllodes tumor.

This is predominantly a tumor of adult women, with very few examples reported in adolescents. Patients typically present with a firm, palpable mass. These tumors are very fast-growing, and can increase in size in just a few weeks. Occurrence is most common between the ages of 40 and 50, prior to menopause. This is about 15 years older than the typical age of patients with fibroadenoma, a condition with which phyllodes tumors may be confused. They have been documented to occur at any age above 12 years (reference needed).

Treatment

The common treatment for phyllodes is wide local excision.^[1] Other than surgery, there is no cure for phyllodes, as chemotherapy and radiation therapy are not effective. The risk of developing local recurrence or metastases is related to the histologic grade, according to the above-named features. Despite wide excision, a very high percentage of surgeries yielded incomplete excision margins that required revision surgery.^[4] Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the local recurrence rate for borderline and malignant tumors.^[5] The authors of a 2012 study have derived a risk calculator for relapse risk of phyllodes tumors after surgery.^[6]

Spectrum

Phyllodes tumors are considered to be on a spectrum of disease^[7] that consists of fibroadenoma, fibroadenoma variant and benign phyllodes. Some would extend the spectrum to include malignant phyllodes tumors and frank sarcoma.^{[citation needed]}

References

^ ^a ^b Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH (2016). "Phyllodes tumours of the breast: a consensus review.". Histopathology. 68 (1): 5–21. doi:10.1111/his.12876.
^ Moffat CJ, Pinder SE, Dixon AR, Elston CW, Blamey RW, Ellis IO (1995). "Phyllodes tumour of the breast: a clinicopathological review of the thirty-two cases.". Histopathology. 27 (3): 205–18. doi:10.1111/j.1365-2559.1995.tb00212.x. PMID 8522284.
^ Sivaram, P.; Jayan, C.; Sulfekar, M. S. & Rahul, M. (2015). "Metastatic Malignant Phyllodes Tumour: An Interesting Presentation as a Parotid Swelling". New Indian Journal of Surgery. 6 (3): 75–77.
^ ^a ^b Guillot, E.; Couturaud, B.; Reyal, F.; Curnier, A.; Ravinet, J.; Laé, M.; Bollet, M.; Pierga, J. Y.; Salmon, R.; Fitoussi, A.; Breast Cancer Study Group of the Institut Curie (2011). "Management of Phyllodes Breast Tumors". The Breast Journal. 17 (2): 129–137. doi:10.1111/j.1524-4741.2010.01045.x. PMID 21251125.
^ Barth RJ Jr; Wells WA; Mitchell SE; Cole BF (2009). "A prospective, multi-institutional study of adjuvant radiotherapy after resection of malignant phyllodes tumors.". Ann Surg Oncol. 16 (8): 2288–94. doi:10.1245/s10434-009-0489-2. PMID 19424757.
^ This is available at www.phyllodes.com. Tan PH, Thike AA, Tan WJ, Thu MM, Busmanis I, Li H, Chay WY, Tan MH (2012). "Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins.". J Clin Path. 65 (1): 69–76. doi:10.1136/jclinpath-2011-200368. PMID 22049216.
^ Deen SA, McKee GT, Kissin MW (1999). "Differential cytologic features of fibroepithelial lesions of the breast". Diagn. Cytopathol. 20 (2): 53–6. doi:10.1002/(SICI)1097-0339(199902)20:2<53::AID-DC1>3.0.CO;2-T. PMID 9951596.

External links

Phyllodes Support Group Over 1000 members
Phyllodes Statistics Self-reported statistics from over 200 phyllodes patients
Phyllodes Tumor Group on Rare Cancer - We have over 180 members waiting to give you support and share information.
Cystosarcoma Phyllodes
Phyllodes Tumor Recurrence Risk Assessment Calculator

UpToDate Contents

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1. 乳房の葉状腫瘍 phyllodes tumors of the breast
2. 小児および思春期における乳房腫瘤の概要 overview of breast masses in children and adolescents
3. 乳房肉腫：疫学、危険因子、臨床症状、診断、およびステージング breast sarcoma epidemiology risk factors clinical presentation diagnosis and staging
4. 良性乳房疾患の概要 overview of benign breast disease
5. 乳癌の臨床的特徴、診断および病期分類 clinical features diagnosis and staging of newly diagnosed breast cancer

English Journal

Phyllodes Tumor of the Breast: Role of CD10 in Predicting Metastasis.

Al-Masri M, Darwazeh G, Sawalhi S, Mughrabi A, Sughayer M, Al-Shatti M.SourceDepartment of Surgical Oncology, King Hussein Cancer Center, Amman, Jordan, malmasri@khcc.jo.
Annals of surgical oncology.Ann Surg Oncol.2011 Oct 18. [Epub ahead of print]
BACKGROUND: Phyllodes tumors are classified as benign, borderline, and malignant according to a group of histological features. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The immunohistochemic
PMID 22006372

Japanese Journal

Benign breast lesions in adolescent girls : an overview with a case report

AGARWAL Prakash,SPARNON Anthony L.
Pediatric surgery international 21(5), 381-382, 2005-05-01
NAID 10019040283

「葉状腫瘍」

Phyllodes tumor
	Micrograph of a phyllodes tumor (right of image) with the characteristic long clefts and myxoid cellular stroma. Normal breast and fibrocystic change are also seen (left of image). H&E stain.
Classification and external resources
ICD-10	C50, D24, D48.6
ICD-9-CM	217
ICD-O	M9020
DiseasesDB	3396
eMedicine	med/500
MeSH	D003557
	[edit on Wikidata]

　　[★]

英: phyllodes tumor
ラ: cystosarcoma phyllodes
同: 葉状嚢胞肉腫
関: 乳房

同: 葉状嚢胞肉腫

2008/12/16 内分泌病理 (breast_patology.ppt)

混合腫瘍・悪性

特徴

線維腺腫と同様、上皮と線維性結合組織の両成分で構成される腫瘍で、線維腺腫にくらべて間質の増生が強く、葉状構造をとる
間質細胞の性状より良性、境界病変および悪性の３種に区分する（上皮のみの悪性はない）

病理

間質の増生が強い
乳管が引き延ばされて複雑な形をしている。
全体

良性と悪性

[http:.2F.2Fonlinelibrary.wiley.com.2Fdoi.2F10.1111.2Fhis.12876.2Fpdf-1] Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH (2016). "Phyllodes tumours of the breast: a consensus review.". Histopathology. 68 (1): 5–21. doi:10.1111/his.12876.

[PMID_8522284-2] Moffat CJ, Pinder SE, Dixon AR, Elston CW, Blamey RW, Ellis IO (1995). "Phyllodes tumour of the breast: a clinicopathological review of the thirty-two cases.". Histopathology. 27 (3): 205–18. doi:10.1111/j.1365-2559.1995.tb00212.x. PMID 8522284.

[3] Sivaram, P.; Jayan, C.; Sulfekar, M. S. & Rahul, M. (2015). "Metastatic Malignant Phyllodes Tumour: An Interesting Presentation as a Parotid Swelling". New Indian Journal of Surgery. 6 (3): 75–77.

[Guillot_2011-4] Guillot, E.; Couturaud, B.; Reyal, F.; Curnier, A.; Ravinet, J.; Laé, M.; Bollet, M.; Pierga, J. Y.; Salmon, R.; Fitoussi, A.; Breast Cancer Study Group of the Institut Curie (2011). "Management of Phyllodes Breast Tumors". The Breast Journal. 17 (2): 129–137. doi:10.1111/j.1524-4741.2010.01045.x. PMID 21251125.

[PMID_19424757-5] Barth RJ Jr; Wells WA; Mitchell SE; Cole BF (2009). "A prospective, multi-institutional study of adjuvant radiotherapy after resection of malignant phyllodes tumors.". Ann Surg Oncol. 16 (8): 2288–94. doi:10.1245/s10434-009-0489-2. PMID 19424757.

[PMID_22049216-6] This is available at www.phyllodes.com. Tan PH, Thike AA, Tan WJ, Thu MM, Busmanis I, Li H, Chay WY, Tan MH (2012). "Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins.". J Clin Path. 65 (1): 69–76. doi:10.1136/jclinpath-2011-200368. PMID 22049216.

[7] Deen SA, McKee GT, Kissin MW (1999). "Differential cytologic features of fibroepithelial lesions of the breast". Diagn. Cytopathol. 20 (2): 53–6. doi:10.1002/(SICI)1097-0339(199902)20:2<53::AID-DC1>3.0.CO;2-T. PMID 9951596.

匿名

検索

案内

案内

cystosarcoma phyllodes