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English Journal

Leukotriene D4 induces cognitive impairment through enhancement of CysLT(1)R-mediated amyloid-β generation in mice.

Tang SS, Wang XY, Hong H, Long Y, Li YQ, Xiang GQ, Jiang LY, Zhang HT, Liu LP, Miao MX, Hu M, Zhang TT, Hu W, Ji H, Ye FY.SourceDepartment of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China.
Neuropharmacology.Neuropharmacology.2013 Feb;65:182-92. doi: 10.1016/j.neuropharm.2012.08.026. Epub 2012 Sep 12.
Amyloid plaques in the extracellular parenchyma mainly consist of amyloid-β peptides (Aβ), one of the pathological hallmarks in Alzheimer's disease (AD). In the present study, we examined neuroinflammation, amyloidogenesis, and memory performance following intracerebral infusions of leukotriene D
PMID 22982445

Acute inflammation initiates the regenerative response in the adult zebrafish brain.

Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M.SourceDeutsche Forshungsgemeinschaft-Center for Regenerative Therapies Dresden-Cluster of Excellence, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
Science (New York, N.Y.).Science.2012 Dec 7;338(6112):1353-6. doi: 10.1126/science.1228773. Epub 2012 Nov 8.
The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular
PMID 23138980

Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner

Kawano Tetsuya,Matsuse Hiroto,Tsuchida Tomoko,Fukahori Susumu,Fukushima Chizu,Nishino Tomoya,Kohno Shigeru
Medical Science Monitor 20, 297-302, 2014-02-22
… Background: Cysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. …
NAID 120005438870

Matsuse Hiroto,Kohno Shigeru
Expert Opinion on Pharmacotherapy 15(3), 353-363, 2014-02
… Although inhaled corticosteroids (ICS) play a central role in the treatment of asthma, they cannot achieve good control for all asthmatics, and medications such as leukotriene receptor antagonists (LTRAs) with bronchodilatory and anti-inflammatory effects often serve as alternatives or add-on drugs. … Further, LTRAs are recommended for asthmatics under specific circumstances that are closely associated with cysteinyl leukotrienes (cysLTs). …
NAID 120005394591

Localization and Up-Regulation of Cysteinyl Leukotriene-2 Receptor in Human Allergic Nasal Mucosa

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Allergology International 62(2), 223-228, 2013
… Background: Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. …
NAID 130004873068