| Cumulus oophorus |
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Section of vesicular ovarian follicle of cat. X 50. (Discus proligerus labeled at lower left.)
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| Details |
| Latin |
Cumulus oophorus
Discus proliger |
| Identifiers |
| Gray's |
p.1256 |
Dorlands
/Elsevier |
c_66/12271425 |
| FMA |
18659 |
| Anatomical terminology |
The cumulus oophorus (Latin cumulus=heap, Greek oo=egg + phor=carrier; Latinized ending "-us"), also called discus proligerus, is a cluster of cells (called cumulus cells) that surround the oocyte both in the ovarian follicle and after ovulation. In the antral follicle, it may be regarded as an extension of the membrana granulosa. The innermost layer of these cells is the corona radiata.[1]
This layer of cells must be penetrated by spermatozoa in order for fertilization to occur.
Contents
- 1 Functions
- 2 Gene expression profiling
- 3 References
- 4 External links
Functions
Functions of the cumulus oophorus include coordination of follicular development and oocyte maturation.[2] Mechanisms of the latter include stimulation of amino acid transport and sterol biosynthesis and regulation of oocyte gene transcription.[2]
It also provides energy substrates for oocyte meiotic resumption and promotes glycolysis.[2]
In addition, it provides protection for the oocyte.[2]
Gene expression profiling
As a part of the process of in vitro fertilization, gene expression profiling of cumulus cells can be performed to estimate oocyte quality and the efficiency of an ovarian hyperstimulation protocol, and may indirectly predict oocyte aneuploidy, embryo development and pregnancy outcomes.[2] Increased knowledge in these aspects is useful in, for example, embryo selection.[2]
In gene expression profiling of cumulus cells, genes where increased expression is correlated with higher oocyte competence or better pregnancy outcomes include: HAS2, GREM1 and PTGS2.[2]
In contrast, genes where increased expression is correlated with lower oocyte competence or worse pregnancy outcomes include: BDNF, CCND2, CXCR4, GPX3, HSPB1, DVL3, DHCR7, CTNND1, TRIM28, STAR, AREG, CX43, PTGS2, SCD1 and SCD5.[2]
References
This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)
- ^ Gilbert, Scott F. Developmental Biology (Ninth ed.). Sinauer Associates, Inc. p. 126. ISBN 0878933840.
- ^ a b c d e f g h The Evian Annual Reproduction (EVAR) Workshop Group 2010; Fauser, B. C. J. M.; Diedrich, K.; Bouchard, P.; Domínguez, F.; Matzuk, M.; Franks, S.; Hamamah, S.; Simón, C.; Devroey, P.; Ezcurra, D.; Howles, C. M. (2011). "Contemporary genetic technologies and female reproduction". Human Reproduction Update 17 (6): 829–847. doi:10.1093/humupd/dmr033. PMC 3191938. PMID 21896560.
External links
- Anatomy photo: Reproductive/mammal/ovary5/ovary3 - Comparative Organology at University of California, Davis - "Mammal, bovine ovary (LM, Medium)"
- Swiss embryology (from UL, UB, and UF) dbefruchtung/objectbefru01
- UIUC Histology Subject 366
- Histology image: 18404loa – Histology Learning System at Boston University - "Female Reproductive System: ovary, cumulus oophorus"
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Female reproductive system
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| Internal |
| Adnexa |
| Ovaries |
| Follicles |
- corpus
- hemorrhagicum
- luteum
- albicans
- Theca of follicle
- Follicular antrum
- Corona radiata
- Zona pellucida
- Membrana granulosa
- Perivitelline space
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| Other |
- Germinal epithelium
- Tunica albuginea
- cortex
- Medulla
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| Fallopian tubes |
- Isthmus
- Ampulla
- Infundibulum
- Fimbria
- Ostium
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| Ligaments |
- Proper of ovary
- Suspensory of ovary
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| Wolffian vestiges |
- Gartner's duct
- Epoophoron
- Vesicular appendages of epoophoron
- Paroophoron
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| Uterus |
| Regions |
- corpus/body
- Cervix
- External orifice
- Canal
- Internal orifice
- Supravaginal portion
- Vaginal portion
- Uterine horns
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| Layers |
- Endometrium
- Myometrium
- Perimetrium
- Parametrium
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| Ligaments |
- Round ligament
- Broad ligament
- Cardinal ligament
- Uterosacral ligament
- Pubocervical ligament
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| General |
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| Vagina |
- Fossa of vestibule of vagina
- Vaginal fornix
- Hymen
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| External |
| Vulva |
| Labia |
- Mons pubis
- Labia majora
- Anterior commissure
- Posterior commissure
- Pudendal cleft
- Labia minora
- Frenulum of labia minora
- Frenulum of clitoris
- Vulval vestibule
- Interlabial sulci
- Bulb of vestibule
- Vaginal orifice
- vestibular glands/ducts
- Bartholin's glands/Bartholin's ducts
- Skene's glands/Skene's ducts
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| Clitoris |
- Crus of clitoris
- Corpus cavernosum
- Clitoral glans
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| Urethra |
- Urethral crest
- Lacunae of Morgagni
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| Other |
- G-spot
- Urethral sponge
- Perineal sponge
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Index of reproductive medicine
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| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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