WordNet

reach the highest or most decisive point
bring to a head or to the highest point; "Seurat culminated pointillism"
rise to, or form, a summit; "The helmet culminated in a crest"
end, especially to reach a final or climactic stage; "The meeting culminated in a tearful embrace" (同)climax
reach the highest altitude or the meridian, of a celestial body

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1. T細胞受容体シグナル伝達 t cell receptor signaling
2. 癌における悪液質の病因、臨床的特徴および評価 pathogenesis clinical features and assessment of cancer cachexia
3. 感染性心内膜炎における疣贅形成の病態 pathogenesis of vegetation formation in infective endocarditis
4. 癌疼痛の評価 assessment of cancer pain
5. 機械的人工換気の肺障害の炎症メカニズム inflammatory mechanisms of lung injury during mechanical ventilation

Chapman DG1, Tully JE, Nolin JD, Janssen-Heininger YM, Irvin CG.
Journal of cellular biochemistry.J Cell Biochem.2014 Dec;115(12):2055-64. doi: 10.1002/jcb.24881.
In a complex inflammatory airways disease such as asthma, abnormalities in a plethora of molecular and cellular pathways ultimately culminate in characteristic impairments in respiratory function. The ability to study disease pathophysiology in the setting of a functioning immune and respiratory sys
PMID 25043224

Grove J1, Metcalf DJ2, Knight AE2, Wavre-Shapton ST3, Sun T3, Protonotarios ED4, Griffin LD4, Lippincott-Schwartz J5, Marsh M6.
Molecular biology of the cell.Mol Biol Cell.2014 Nov 5;25(22):3581-94. doi: 10.1091/mbc.E14-06-1154. Epub 2014 Aug 27.
Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells. Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma membrane, which invaginate to form clathrin-coated vesicles, a process that is well understood. However, clathrin also assembles in
PMID 25165141

Differential effects of STAT proteins on growth hormone-mediated IGF-I gene expression.

Varco-Merth B1, Rotwein P2.
American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2014 Nov 1;307(9):E847-55. doi: 10.1152/ajpendo.00324.2014. Epub 2014 Sep 9.
Growth hormone (GH) plays a key role regulating somatic growth and in controlling metabolism and other physiological processes in humans and other animal species. GH acts by binding to the extracellular part of its transmembrane receptor, leading to induction of multiple intracellular signal transdu
PMID 25205818

Differential roles of ATF-2 in survival and DNA repair contributing to radioresistance induced by autocrine soluble factors in A549 lung cancer cells.

Desai S1, Kumar A1, Laskar S2, Pandey BN3.
Cellular signalling.Cell Signal.2014 Nov;26(11):2424-35. doi: 10.1016/j.cellsig.2014.07.021. Epub 2014 Jul 17.
Radioresistance is one of the obstacles to the effective radiotherapy for non-small cell lung cancer. Soluble factors in the tumour microenvironment are often implicated in radioresistance but the underpinning mechanism(s) remain largely elusive. We herein studied the wholesome effect of autocrine c
PMID 25041846

SIVY Tami L.,FALL Ray,ROSENSTIEL Todd N.
Bioscience, biotechnology, and biochemistry 75(12), 2376-2383, 2011-12-23
… The mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathways for isoprenoid biosynthesis both culminate in the production of the two-five carbon prenyl diphosphates: dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP). …
NAID 10030397815

杉村篤志
アメリカ文学研究 (47), 1-17, 2011-03-31
… question of slavery, that the abolitionists can accomplish their object." If, as Joan Dayan maintains in "Poe, Persons, and Property" (1999), Poe was "ultimately concerned with the law," and the black slave was virtually a "creature of law," the legitimacy and legality of Wilson's conscience's "rebellion" can be reconsidered within the historical context of Abolitionism along with Poe's own apocalyptic vision of democratic history as likely to culminate in an overwhelming victory of, and consequent retribution by, the black people over their white …
NAID 110009631701

杉田尚男,藤原広和,佐々木淳,夏堀徹,鎌田長幸,工藤隆男
論文集「高専教育」 : kosen kyoiku (34), 505-509, 2011-03
… curriculum should include engineering science content which imparts an appreciation of important elements of other engineering disciplines.Engineering design integrates mathematics,basic sciences,engineering sciences and complementary studies in developing elements,systems and processes to meet specific needs.The engineering curriculum must culminate in a significant design experience which is based on the knowledge and skills acquired in earlier course work and which preferably gives students an exposure to the concepts of team work and project …
NAID 110009676339

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation

Ebihara Takashi,Azuma Masahiro,Oshiumi Hiroyuki,Kasamatsu Jun,Iwabuchi Kazuya,Matsumoto Kenji,Saito Hirohisa,Taniguchi Tadatsugu,Matsumoto Misako,Seya Tsukasa
Journal of Experimental Medicine 207(12), 2675-2687, 2010-11-08
… TICAM-1 signals culminate in interferon (IFN) regulatory factor (IRF) 3 activation. …
NAID 120002722561