WordNet

distinctly or sharply outlined; "crystalline sharpness of outline"- John Buchan
transmitting light; able to be seen through with clarity; "the cold crystalline water of melted snow"; "crystal clear skies"; "could see the sand on the bottom of the limpid pool"; "lucid air"; "a pellucid brook"; "transparent crystal" (同)crystal clear, limpid, lucid, pellucid, transparent
consisting of or containing or of the nature of crystals; "granite is crystalline"
coat or cover with zinc
a bluish-white lustrous metallic element; brittle at ordinary temperatures but malleable when heated; used in a wide variety of alloys and in galvanizing iron; it occurs naturally as zinc sulphide in zinc blende (同)Zn, atomic number 30
hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells

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1. インスリンに対する過敏症反応 hypersensitivity reactions to insulins
2. 糖尿病におけるインスリン療法の一般原則 general principles of insulin therapy in diabetes mellitus
3. 前立腺癌の危険因子 risk factors for prostate cancer
4. 食物中の微量ミネラルの概要 overview of dietary trace minerals
5. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus

A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.

Attia EA1, Belal DM, El Samahy MH, El Hamamsy MH.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.Wound Repair Regen.2014 Jan-Feb;22(1):52-7. doi: 10.1111/wrr.12122.
When wounds are treated with regular insulin, they are also being treated with zinc; used in the formula to crystallize insulin molecules. It is not clear if regular insulin-accelerated wound healing is due to insulin, the zinc it contains, or both. Thus, we aimed to compare topical regular crystall
PMID 24393153

O'Halloran TV, Kebede M, Philips SJ, Attie AD.
The Journal of clinical investigation.J Clin Invest.2013 Oct 1;123(10):4136-9. doi: 10.1172/JCI72325. Epub 2013 Sep 24.
Insulin and Zn2+ enjoy a multivalent relationship. Zn2+ binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in insuli
PMID 24051373

Photolysis of recombinant human insulin in the solid state: formation of a dithiohemiacetal product at the C-terminal disulfide bond.

Mozziconacci O1, Haywood J, Gorman EM, Munson E, Schöneich C.
Pharmaceutical research.Pharm Res.2012 Jan;29(1):121-33. doi: 10.1007/s11095-011-0519-1. Epub 2011 Jul 12.
PURPOSE: Exposure of protein pharmaceuticals to light can result in chemical and physical modifications, potentially leading to loss of potency, aggregation, and/or immunogenicity. To correlate these potential consequences with molecular changes, the nature of photoproducts and their mechanisms of f
PMID 21748537

A Study on Monocomponent Insulin III. The Purity and Stability of Pharmaceutical Preparations

笠間俊男,内田迫子,米沢正一,田村典子,横井喜代四
糖尿病 19(5), 680-691, 1976
… Though MC insulin preparations are said to have been developed from which the heterogeneous peptic contaminants have been removed, for the purpose of lowering the immunogenicity of insulin, a recent report claims the detection of considerable quantities of both substances with molecular weights higher than that of insulin and desamidoinsulin. …
NAID 130004336578

笠間俊男,中島久代,米沢正一,飯山保,内田迪子,中川昌一
糖尿病 18(1), 29-33, 1975
… effect of Monocomponent insulin (MI) was examinedcompared with conventional insulin (CI) in normal rabbits and rabbits immunized with beef insulin.<BR>Using neutral soluble insulin preparations, there was no differrence for the maximal rate and duration of the hypoglycemic effect between the MI and the CI in the normal and immunized rabbits, but in the immunized rabbits the hypoglycemic effect of both insulin preparations was delayed as …
NAID 130004336466