| Cryoablation |
| Intervention |
| ICD-9-CM |
37.33, 37.34, 60.62 |
| MeSH |
D003452 |
Cryoablation is a process that uses extreme cold (cryo) to destroy or damage tissue (ablation).
Cryoablation is used in a variety of clinical applications using hollow needles (cryoprobes) through which cooled, thermally conductive, fluids are circulated. Cryoprobes are inserted into or placed adjacent to tissue which is determined to be diseased in such a way that ablation will provide correction yielding benefit to the patient. When the probes are in place, the cryogenic freezing unit removes heat ("cools") from the tip of the probe and by extension from the surrounding tissues.
Ablation occurs in tissue that has been frozen by at least three mechanisms:
- formation of ice crystals within cells thereby disrupting membranes, and interrupting cellular metabolism among other processes;
- coagulation of blood thereby interrupting bloodflow to the tissue in turn causing ischemia and cell death; and
- induction of apoptosis, the so-called programmed cell death cascade.
The most common application of cryoablation is to ablate solid tumors found in the lung, liver, breast, kidney and prostate. The use in prostate and renal cryoablation are the most common. Although sometimes applied through laparoscopic or open surgical approaches, most often cryoablation is performed percutaneously (through the skin and into the target tissue containing the tumor) by a medical specialist, such as an interventional radiologist.
Contents
- 1 Prostate cryoablation
- 2 Renal
- 3 Breast cancer
- 4 Cardiac
- 5 Fibroadenoma
- 6 Catheter-based procedures
- 7 Site testing
- 8 Surgical procedures
- 9 See also
- 10 References
Prostate cryoablation
Prostate cryoablation is moderately effective but, as with any prostate removal process, also can result in impotence. Prostate cryoablation is used in three patient categories:
- as primary therapy in patients for whom sexual function is less important or who are poor candidates for radical retropubic prostatectomy (RRP, surgical removal of the prostate);
- as salvage therapy in patients who have failed brachytherapy (the use of implanted radioactive "seeds" placed within the prostate) or external beam radiation therapy (EBRT); and
- focal therapy for smaller, discrete tumors in younger patients.
Renal
Cryoablation has similar outcomes to radiofrequency ablation when treating renal cell carcinoma.[1]
Breast cancer
Cryoablation for breast cancer is typically only possible for small tumors.[2] Often surgery is used following cryoablation.[2] As of 2014 more research is required before it can replace lumpectomy.[2]
Cardiac
Another type of cryoablation is used to restore normal electrical conduction by freezing tissue or heart pathways that interfere with the normal distribution of the heart’s electrical impulses. Cryoablation is used in two types of intervention for the treatment of arrhythmias: (1) catheter-based procedures and (2) surgical operations.
A catheter is a very thin tube that is inserted into a vein in the patient’s leg and threaded to the heart where it delivers energy to treat the patient’s arrhythmia. In surgical procedures, a flexible probe is used directly on an exposed heart to apply the energy that interrupts the arrhythmia. By cooling the tip of a cryoablation catheter (cardiology) or probe (heart surgery) to sub-zero temperatures, the cells in the heart responsible for conducting the arrhythmia are altered so that they no longer conduct electrical impulses.
Fibroadenoma
Cryoablation is also currently being used to treat fibroadenomas of the breast. Fibroadenomas are benign breast tumors that are found in approximately 10% of women (primarily ages 15–30).[3]
In this procedure which has been approved by the U.S. Food and Drug Administration (FDA), an ultrasound-guided probe is inserted into the fibroadenoma and extremely cold temperatures are then used to destroy the abnormal cells.[4] Over time the cells are reabsorbed into the body. The procedure can be performed in a doctor's office setting with local anesthesia and leaves very little scarring compared to open surgical procedures.[4]
Catheter-based procedures
Different catheter-based ablation techniques may be used and they generally fall into two categories: (1) cold-based procedures where tissue cooling is used to treat the arrhythmia, and (2) heat-based procedures where high temperature is used to alter the abnormal conductive tissue in the heart.
Cryoablation
Cold temperatures are used in cryoablation to chill or freeze cells that conduct abnormal heart rhythms. The catheter removes heat from the tissue to cool it to temperatures as low as -75 °C. This causes localized scarring, which cuts undesired conduction paths.
This is a much newer treatment for supraventricular tachycardia (SVT) involving the atrioventicular (AV) node directly. SVT involving the AV node is often a contraindication for using radiofrequency ablation because of the risk of injuring the AV node, forcing patients to receive a permanent pacemaker. With cryoablation, areas of tissue can be mapped by limited, reversible, freezing (e.g., to -10 C). If the result is undesirable, the tissue can be rewarmed without permanent damage. Otherwise, the tissue can be permanently ablated by freezing it to a lower temperature (e.g., -73 C).
This therapy has revolutionized AV nodal reentrant tachycardia (AVNRT) and other AV nodal tachyarrhythmias. It has allowed people who were otherwise not a candidate for radiofrequency ablation to have a chance at having their problem cured. This technology was developed at The Montreal Heart institute in the late 1990s. The therapy was successfully adopted in Europe in 2001, and in the USA in 2004 following the "Frosty Trial".[5]
In 2004, the technology was pioneered in the midwest United States at Miami Valley Hospital in Dayton, Ohio by Mark Krebs, MD, FACC, Matthew Hoskins, RN, BSN and Ken Peterman, RN, BSN. These electrophysiology experts were successful in curing the first 12 candidates in their facility. Many more have been successfully treated since and they continue their work in the field.
Cryoablation for AVNRT and other arrhythmias do have some drawbacks. A recent study[6] concluded that procedure times are slightly higher on average for cryoablation than for traditional radio-frequency (heat-based) ablations. Also, higher rate of equipment failures were recorded using this technique. Finally, even though short term success rate is equivalent to RF treatments, cryoablation appears to have a significantly higher long term recurrence rate.
Site testing
Cryotherapy is able to produce a temporary electrical block by cooling down the tissue believed to be conducting the arrhythmia. This allows the physician to make sure this is the right site before permanently disabling it. The ability to test a site in this way is referred to as site testing or cryomapping.
When ablating tissue near the AV node (a special conduction center that carries electrical impulses from the atria to the ventricles), there is a risk of producing heart block - that is, normal conduction from the atria cannot be transmitted to the ventricles. Freezing tissue near the AV node is less likely to provoke irreversible heart block than ablating it with heat.
Surgical procedures
As in catheter-based procedures, techniques using heating or cooling temperatures may be used to treat arrhythmias during heart surgery. Techniques also exist where incisions are used in the open heart to interrupt abnormal electrical conduction (Maze procedure). Cryosurgery involves the use of freezing techniques for the treatment of arrhythmias during surgery.
A physician may recommend cryosurgery being used during the course of heart surgery as a secondary procedure to treat any arrhythmia that was present or that may appear during the primary openchest procedure. The most common heart operations in which cryosurgery may be used in this way are mitral valve repairs and coronary artery bypass grafting. During the procedure, a flexible cryoprobe is placed on or around the heart and delivers cold energy that disables tissue responsible for conducting the arrhythmia.
See also
References
- General references
- Liapi E, Geschwind JF. J Clin Oncol. Transcatheter and ablative therapeutic approaches for solid malignancies. 2007 Mar 10;25(8):978-86.
- Rukstalis, D and KatzHandbook, A Handbook of Urologic Cryoablation, hardcover - Feb 13, 2007.
- Jensen-Urstad, et al., Cryoablation of AV Nodal Reentrytachycardia, PACE, Vol. 29 May 2006, pp 487.
- Doll, et al., Intraoperative Cryoablation with a new Argon Probe, Ann Thorac Surg 2004;77:1460–2.
- Inline citations
- ^ El Dib, R; Touma, NJ; Kapoor, A (August 2012). "Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma: a meta-analysis of case series studies.". BJU international 110 (4): 510–6. PMID 22304329.
- ^ a b c Sabel, MS (July 2014). "Nonsurgical ablation of breast cancer: future options for small breast tumors.". Surgical oncology clinics of North America 23 (3): 593–608. PMID 24882353.
- ^ Medical Dictionary
- ^ a b WebMD - Cryotherapy Shrinks Benign Breast Lumps
- ^ http://www.cryocath.com/de/7.neuigkeiten/7.0.neuigkeiten.asp?id=385
- ^ Nov. 2010 German CYRANO study (Cryoablation Versus Radiofrequency Energy for the Ablation of Atrioventricular Nodal Reentrant Tachycardia)
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Surgery and other procedures involving the heart (ICD-9-CM V3 35–37+89.4+99.6, ICD-10-PCS 02)
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| Surgery and IC |
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Heart valves
and septa
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- Valve repair
- Valvulotomy
- Mitral valve repair
- Valvuloplasty
- Valve replacement
- Aortic valve replacement
- Ross procedure
- Percutaneous aortic valve replacement
- Mitral valve replacement
- production of septal defect in heart
- enlargement of existing septal defect
- Atrial septostomy
- Balloon septostomy
- creation of septal defect in heart
- Blalock–Hanlon procedure
- shunt from heart chamber to blood vessel
- atrium to pulmonary artery
- Fontan procedure
- left ventricle to aorta
- Rastelli procedure
- right ventricle to pulmonary artery
- Sano shunt
- compound procedures
- for transposition of great vessels
- Jatene procedure
- Mustard procedure
- for univentricular defect
- Norwood procedure
- Kawashima procedure
- shunt from blood vessel to blood vessel
- systemic circulation to pulmonary artery shunt
- Blalock–Taussig shunt
- SVC to the right PA
- Glenn procedure
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Cardiac vessels
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- CHD
- Angioplasty
- Bypass/Coronary artery bypass
- MIDCAB
- Off-pump CAB
- TECAB
- Coronary stent
- Bare-metal stent
- Drug-eluting stent
- Bentall procedure
- Valve-sparing aortic root replacement
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Other
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- Pericardium
- Pericardiocentesis
- Pericardial window
- Pericardiectomy
- Myocardium
- Cardiomyoplasty
- Dor procedure
- Septal myectomy
- Ventricular reduction
- Alcohol septal ablation
- Conduction system
- Maze procedure
- Cox maze and minimaze
- Catheter ablation
- Cryoablation
- Radiofrequency ablation
- Pacemaker insertion
- Left atrial appendage occlusion
- Cardiotomy
- Heart transplantation
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Diagnostic
tests and
procedures |
- Electrophysiology
- Electrocardiography
- Vectorcardiography
- Holter monitor
- Implantable loop recorder
- Cardiac stress test
- Bruce protocol
- Electrophysiology study
- Cardiac imaging
- Angiocardiography
- Echocardiography
- TTE
- TEE
- Myocardial perfusion imaging
- Cardiovascular MRI
- Ventriculography
- Radionuclide ventriculography
- Cardiac catheterization/Coronary catheterization
- Cardiac CT
- Cardiac PET
- sound
- Phonocardiogram
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| Function tests |
- Impedance cardiography
- Ballistocardiography
- Cardiotocography
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| Pacing |
- Cardioversion
- Transcutaneous pacing
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Index of the heart
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Injury
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- glycosides
- other stimulants
- antiarrhythmics
- vasodilators
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Male genital surgical and other procedures: reproductive system (ICD-9-CM V3 60–64, ICD-10-PCS 0V)
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| Internal |
| Prostate |
- Transurethral incision of the prostate
- Prostate biopsy
- Transrectal biopsy
- Transurethral biopsy
- Prostatectomy
- Transurethral resection of the prostate
- Radical retropubic prostatectomy
- Transurethral microwave thermotherapy
- Transurethral needle ablation of the prostate
- Brachytherapy
- Prostate massage
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| seminal vesicles: |
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| Vas deferens |
- Vasectomy
- Vasectomy reversal
- Vasovasostomy
- Vasoepididymostomy
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| Testes |
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| External |
| Penis |
- Circumcision
- Penectomy
- Penile prosthesis
- Preputioplasty
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- Penile plethysmograph
- Postage stamp test
- Frenuloplasty of prepuce of penis
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| Tests |
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Index of reproductive medicine
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| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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