- A comparative study of validated spectrophotometric and TLC- spectrodensitometric methods for the determination of sodium cromoglicate and fluorometholone in ophthalmic solution.
- Saleh SS, Lotfy HM, Hassan NY, Elgizawy SM.Author information Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 11787 6[th] October City, Egypt.AbstractThe determination of sodium cromoglicate (SCG) and fluorometholone (FLU) in ophthalmic solution was developed by simple, sensitive and precise methods. Three spectrophotometric methods were applied: absorptivity factor (a-Factor method), absorption factor (AFM) and mean centering of ratio spectra (MCR). The linearity ranges of SCG were found to be (2.5-35 μg/mL) for (a-Factor method) and (MCR); while for (AFM), it was found to be (7.5-50 μg/mL). The linearity ranges of FLU were found to be (4-16 μg/mL) for (a-Factor method) and (AFM); while for (MCR), it was found to be (2-16 μg/mL). The mean percentage recoveries/RSD for SCG were found to be 100.31/0.90, 100.23/0.57 and 100.43/1.21; while for FLU, they were found to be 100.11/0.56, 99.97/0.35 and 99.94/0.88 using (a-Factor method), (AFM) and (MCR), respectively. A TLC-spectrodensitometric method was developed by separation of SCG and FLU on silica gel 60 F254 using chloroform:methanol:toluene:triethylamine in the ratio of (5:2:4:1 v/v/v/v) as developing system, followed by spectrodensitometric measurement of the bands at 241 nm. The linearity ranges and the mean percentage recoveries/RSD were found to be (0.4-4.4 μg/band), 100.24/1.44 and (0.2-1.6 μg/band), 99.95/1.50 for SCG and FLU, respectively. A comparative study was conducted between the proposed methods to discuss the advantage of each method. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for the determination of SCG and FLU in their laboratory prepared mixtures and commercial ophthalmic solution in the presence of benzalkonium chloride as a preservative. These methods could be an alternative to different HPLC techniques in quality control laboratories lacking the required facilities for those expensive techniques.
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.Saudi Pharm J.2013 Oct;21(4):411-21. doi: 10.1016/j.jsps.2012.11.001.
- The determination of sodium cromoglicate (SCG) and fluorometholone (FLU) in ophthalmic solution was developed by simple, sensitive and precise methods. Three spectrophotometric methods were applied: absorptivity factor (a-Factor method), absorption factor (AFM) and mean centering of ratio spectra (M
- PMID 24227962
- Topical use of sodium cromoglicate (cromolyn sodium) to treat atopic dermatitis and other skin allergies.
- Zur E.Author information Super-Pharm, Petach-Tikvah, Israel. email@example.comAbstractSodium cromoglicate (cromolyn sodium) is a very well-known medicine that has been used for many years for various allergic conditions. The topical use of this medicine is less known, and there are no commercial medicines of cream, gel, or lotion in most of the world. This article summarizes the clinical data accumulated from seventeen trials that checked the topical efficacy and safety of sodium cromoglicate and analyzes the clinical implementations of this medicine in the topical treatment of atopic dermatitis and other skin allergies. In addition, this article analyzes the various formulations that have been used in the clinical trials in an attempt to find the optimal formulation. The topical use of sodium cromoglicate seemed to have a promising potential, and implementing the data of this article can allow the compounding pharmacist a very interesting professional activity in very common and widespread allergic pathologies.
- International journal of pharmaceutical compounding.Int J Pharm Compd.2012 Sep-Oct;16(5):386-93.
- Sodium cromoglicate (cromolyn sodium) is a very well-known medicine that has been used for many years for various allergic conditions. The topical use of this medicine is less known, and there are no commercial medicines of cream, gel, or lotion in most of the world. This article summarizes the clin
- PMID 23072198
- In vivo hydroquinone exposure causes tracheal hyperresponsiveness due to TNF secretion by epithelial cells.
- Shimada AL, Lino-Dos-Santos-Franco A, Bolonheis SM, Nakasato A, Damazo AS, Tavares-de-Lima W, Farsky SH.Author information Laboratory of Experimental Toxicology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Brazil.AbstractHydroquinone (HQ) is the main oxidative substance in cigarette smoke and a toxic product of benzene biotransformation. Although the respiratory tract is an inlet pathway of HQ exposure, its effect on airway muscle responsiveness has not been assessed. We thus investigated the effects of low dose in vivo HQ-exposure on tracheal responsiveness to a muscarinic receptor agonist. Male Swiss mice were exposed to aerosolised 5% ethanol/saline solution (HQ vehicle; control) or 0.04 ppm HQ (1h/day for 5 days) and tracheal rings were collected 1h after the last exposure. HQ exposure caused tracheal hyperresponsiveness to methacholine (MCh), which was abolished by mechanical removal of the epithelium. This hyperresponsiveness was not dependent on neutrophil infiltration, but on tumour necrosis factor (TNF) secretion by epithelial cells. This conclusion was based on the following data: (1) trachea from HQ-exposed mice presented a higher amount of TNF, which was abrogated following removal of the epithelium; (2) the trachea hyperresponsiveness and TNF levels were attenuated by in vivo chlorpromazine (CPZ) treatment, an inhibitor of TNF synthesis. The involvement of HQ-induced TNF secretion in trachea mast cell degranulation was also demonstrated by the partial reversion of tracheal hyperresponsiveness in sodium cromoglicate-treated animals, and the in vivo HQ-exposure-induced degranulation of trachea connective tissue and mucosal mast cells, which was reversed by CPZ treatment. Our data show that in vivo HQ exposure indirectly exacerbates the parasympathetic-induced contraction of airway smooth muscle cells, mediated by TNF secreted by tracheal epithelial cells, clearly showing the link between environmental HQ exposure and the reactivity of airways.
- Toxicology letters.Toxicol Lett.2012 May 20;211(1):10-7. doi: 10.1016/j.toxlet.2012.02.016. Epub 2012 Mar 5.
- Hydroquinone (HQ) is the main oxidative substance in cigarette smoke and a toxic product of benzene biotransformation. Although the respiratory tract is an inlet pathway of HQ exposure, its effect on airway muscle responsiveness has not been assessed. We thus investigated the effects of low dose in
- PMID 22414385
- 福田 正道,村野 秀和,山本 佳代,山代 陽子,高橋 信夫,萩原 健太,北川 和子,佐々木 洋
- 眼薬理 = Japanese journal of ocular pharmacology 20(1), 41-44, 2006-09-08
- NAID 10018257013
- 福田 正道,村野 秀和,山本 佳代 [他],山代 陽子,高橋 信夫,萩原 健太,北川 和子,佐々木 洋
- あたらしい眼科 = Journal of the eye 22(12), 1675-1678, 2005-12-30
- NAID 10020399982
- A RANDOMIZED, GROUP-PARALLEL COMPARATIVE TRIAL OF THE SUPPRESSIVE EFFECT OF CHINESE TRADITIONAL MEDICINE, SHEN-MI-TANG (SHIN-PI-TO), COMPARED TO SODIUM ORAMOYLYCATE INHALATION IN IMPROVING SUBJECTIVE AND OBJECTIVE SYMPTOMS IN BRONCHIAL ASTHMATICS
- 西澤 芳男,西澤 恭子,後藤 グレイシイ・広恵,吉岡 二三,野坂 修一,雨森 保憲,谷垣 由美子,永野 富美代,山田 まゆみ,平田 弥生,安田 理絵,川田 陽子,天方 義邦,伏木 信次
- 耳鼻咽喉科展望 47, 20-27, 2004
- … Patients in group B inhaled sodium cromoglicate (CSCG) (20 mg/1 capsule) in the same administraton using DSCG-spinhela. …
- NAID 130003975310
- クロモグリク酸ナトリウム(Sodium cromoglicate)の検索ならお薬検索QLife（キューライフ）。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤 ...
- Sodium Cromoglicate 販売元 和光純薬工業(株) 販売元コード 193-15231,199-15233 製造元 製造元コード CAS.NO 15826-37-6 分子式 C23H14O11Na2 分子量 512.33 512.33 保存条件 室温 適用法規 危険有害性 等級 薬理研究用 ...
- クロモグリク酸ナトリウム, sodium cromoglicate, natrii cromoglicas
- クロモリンナトリウム cromolyn sodium
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- Crolom, Intal, Gastrocrom, Nasalcrom
- cromoglicic acid、cromoglycate、cromoglycic acid、cromolyn sodium、disodium cromoglycate、sodium cromoglicate