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1. 成人における再発寛解型多発性硬化症の治療 treatment of relapsing remitting multiple sclerosis in adults
2. 多発性硬化症が疑われる最初のエピソードからなる症候群 clinically isolated syndromes suggestive of multiple sclerosis
3. 成人における進行性多発性硬化症の治療 treatment of progressive multiple sclerosis in adults
4. 小児多発性硬化症の治療および予後 treatment and prognosis of pediatric multiple sclerosis
5. 成人における再発寛解型多発性硬化症に対するナタリズマブ natalizumab for relapsing remitting multiple sclerosis in adults

Synthesis of β-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.

Zhang J, Ellsworth K, Ma PX.SourceDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Macromolecular rapid communications.Macromol Rapid Commun.2012 Apr 23;33(8):664-71. doi: 10.1002/marc.201100814. Epub 2012 Feb 9.
We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one β-cyclodextrin (β-CD) containing block by a "click" reaction between azido-substituted β-CD and propargyl flanking copolymer. (1)H NMR study suggested a highly efficient conjugation of β-CD units
PMID 22318939

Novel biomimetic vectors with endosomal-escape agent enhancing gene transfection efficiency.

Sun X, Liu C, Liu D, Li P, Zhang N.SourceThe School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji'nan, Shandong Province 250012, China.
International journal of pharmaceutics.Int J Pharm.2012 Apr 4;425(1-2):62-72. Epub 2012 Jan 14.
Low cytotoxicity and high transfection efficiency are critical issues in designing current non-viral gene delivery vectors. In the present study, a novel biomimetic lipid-polycation copolymer, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-graft-poly(l-lysine)-block-poly(ethylene glycol) (DOPE-g-PLL-
PMID 22266532

Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice : cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines