立体構造変化、コンフォメーション変化、コンホメーション変化
- 関
- structural change
WordNet
- cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue" (同)alter, modify
- become different in some particular way, without permanently losing ones or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarkets selection of vegetables varies according to the season" (同)alter, vary
- exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares" (同)exchange, commute, convert
- a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage"
- change clothes; put on different clothes; "Change before you go to the opera"
- coins of small denomination regarded collectively; "he had a pocketful of change"
- money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver"
- remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens"
- the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change"
- the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains"
- undergo a change; become different in essence; losing ones or its original nature; "She changed completely as she grew older"; "The weather changed last night"
- a different or fresh set of clothes; "she brought a change in her overnight bag"
- a thing that is different; "he inspected several changes before selecting one"
- the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election"
- an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago" (同)alteration, modification
- a symmetrical arrangement of the parts of a thing
- made or become different in some respect; "hes an altered (or changed) man since his election to Congress"
- changed in constitution or structure or composition by metamorphism; "metamorphic rocks"
- made or become different in nature or form; "changed attitudes"; "changed styles of dress"; "a greatly changed country after the war"
- marked by continuous change or effective action (同)ever-changing
PrepTutorEJDIC
- (…に)…'を'『変える』,改める《+『名』+『into』+『名』》 / …'を'『取り替える』,交換する / 〈小切手・為替〉'を'現金にする,〈金〉'を'両替えする;(…に)…'を'両替する《+『名』+『into』+『名』》 / (…に)『変わる』,変化する《+『to』(『into』)+『名』》 / (他の衣服に)着替える《+『into』+『名』》 / (…に)乗り換える《+『to』+『名』》 / 〈C〉(…の)『変化』,移り変わり,変遷《+『of』+『名』》 / 〈C〉(…の)『取り替え』,交換;乗り換え《+『of』+『名』》 / 〈U〉釣り銭,小銭
- 〈C〉形態,構造;調和のとれた配置(配列) / 〈U〉(型・性格などべの)一至,適合,適応《+『to』+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/31 07:48:16」(JST)
[Wiki en表示]
Main article: Protein dynamics
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.
A macromolecule is usually flexible and dynamic. It can change its shape in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change. Factors that may induce such changes include:
- temperature,
- pH,
- voltage,
- ion concentration,
- phosphorylation, or
- the binding of a ligand.
Laboratory analysis
Many biophysical techniques such as crystallography, NMR, electron paramagnetic resonance (EPR) using spin label techniques, circular dichroism (CD), hydrogen exchange, and FRET can be used to study macromolecular conformational change. Dual polarisation interferometry is a benchtop technique capable of measuring conformational changes in biomolecules in real time at very high resolution.
A specific nonlinear optical technique called second-harmonic generation (SHG) has been recently applied to the study of conformational change in proteins. In this method, a second-harmonic-active probe is placed at a site that undergoes motion in the protein by mutagenesis or non-site-specific attachment, and the protein is adsorbed or specifically immobilized to a surface. A change in protein conformation produces a change in the net orientation of the dye relative to the surface plane and therefore the intensity of the second harmonic beam. In a protein sample with a well-defined orientation, the tilt angle of the probe can be quantitatively determined, in real space and real time. Second-harmonic-active unnatural amino acids can also be used as probes.
Another method applies electro-switchable biosurfaces where proteins are placed on top of short DNA molecules which are then dragged through a buffer solution by application of alternating electrical potentials. By measuring their speed which ultimately depends on their hydrodynamic friction, conformational changes can be visualized.
See also
- Database of protein conformational diversity
- Protein dynamics
- The Database of Macromolecular Motions (molmovdb)
External links
- Book Chapter on Protein Motions from website of RH Austin [1] at Princeton University
- Frauenfelder, H. New looks at protein motions Nature 338, 623 - 624 (20 April 1989).
- Sensing with electro-switchable biosurfaces
- Biodesy
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Real-time and label-free analyte detection in a flow-through mode using immobilized fluorescent aptamer/quantum dots molecular switches.
- Bogomolova A1, Aldissi M2.
- Biosensors & bioelectronics.Biosens Bioelectron.2015 Apr 15;66:290-6. doi: 10.1016/j.bios.2014.11.034. Epub 2014 Nov 20.
- Inspired by the goal to create a biosensor with designer specificity for real-time detection of unlabeled analytes in a flow-through mode, we designed a miniature flow cell with interchangeable quartz window carrying immobilized aptamer/quantum dot molecular switches as a part of a portable fluoresc
- PMID 25437366
- Effect of a buried ion pair in the hydrophobic core of a protein: An insight from constant pH molecular dynamics study.
- Pathak AK1.
- Biopolymers.Biopolymers.2015 Mar;103(3):148-57. doi: 10.1002/bip.22577.
- Constant pH molecular dynamics (CpHMD) is a commonly used sampling method, which incorporates the coupling of conformational flexibility and protonation state of a protein during the simulation by using pH as an external parameter. The effects on the structure and stability of a hyperstable variant
- PMID 25363335
- Temperature-dependent vibrational spectroscopic study and DFT calculations of the sorbic acid.
- Saraiva GD1, Nogueira CE2, Freire PT3, de Sousa FF4, da Silva JH5, Teixeira AM2, Mendes Filho J3.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Feb 25;137:1409-16. doi: 10.1016/j.saa.2014.08.142. Epub 2014 Oct 10.
- This work reports a temperature-dependent vibrational spectroscopic study of the sorbic acid (C6H8O2), as well as the mode assignment at ambient conditions, based on the density functional theory. Temperature-dependent vibrational properties have been performed in polycrystalline sorbic acid through
- PMID 25310262
Japanese Journal
- Molecular doping of regioregular poly(3-hexylthiophene) layers by 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane investigated by infrared spectroscopy and electrical measurements
- 20719 VWF分子のアンフォルディングにおける血小板粘着力発生
- プリン受容体ヘテロ多量体形成が血小板機能に与える影響の解析
Related Links
- A macromolecule is usually flexible and dynamic. It can change its shape in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change
- Conformational change (Science: cell biology) alteration in the shape usually the tertiary structure of a protein as a result of alteration in the ...
★リンクテーブル★
[★]
- 英
- conformational change、structural change
- 関
- コンフォメーション変化、コンホメーション変化、構造的変化、構造変化
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- 英
- conformational change
- 関
- コンフォメーション変化、立体構造変化
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- 関
- conformational change
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- 英
- conformational change
- 関
- コンホメーション変化、立体構造変化
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- 立体構造の、コンフォメーションの、コンホメーションの、立体構造的な、高次構造上の、高次構造的な、立体配座の、立体配置的な
- 関
- configurational、configurationally、conformation、conformational state、conformationally、structural、structurally、tertiary structure
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- 関
- architecture、conformational、conformational state、constitution、formation、higher order structure、makeup、structure、tertiary structure
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- 関
- alter、alteration、alternate、convert、modification、modify、replacement、shift、switch、turn、turn to、variation、variational、vary