鎖状体、コンカテマー
- 関
- concatamer
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/21 10:45:48」(JST)
[Wiki en表示]
A concatemer is a long continuous DNA molecule that contains multiple copies of the same DNA sequences linked in series. These polymeric molecules are usually copies of an entire genome linked end to end and separated by cos sites (a protein binding nucleotide sequence that occurs once in each copy of the genome). Concatemers are frequently the result of rolling circle replication, and may be seen in the late stage of bacterial infection by phages. As an example, if the genes in the phage DNA are arranged ABC, then in a concatemer the genes would be ABCABCABCABC and so on. They are further broken by ribozymes.[1]
During active infection, some species of viruses have been shown to replicate their genetic material via the formation of concatemers.[2] In the case of human herpesvirus-6, its entire genome is made over and over on a single strand. These long concatemers are subsequently cleaved between the pac-1 and pac-2 regions by ribozymes when the genome is packaged into individual virions.
References [edit]
- ^ Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study of DNA replication intermediates.
- ^ Herpesviruses and Chromosomal Integration.
Bibliography [edit]
- Oxford Dictionary of Biochemistry and Molecular Biology, 2nd ed. R. l., eds. Oxford University Press, 2006. p.138.
English Journal
- Integration, stability and expression of the E. coli phytase transgene in the Cassie line of Yorkshire Enviropig™.
- Forsberg CW, Meidinger RG, Liu M, Cottrill M, Golovan S, Phillips JP.SourceDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada, cforsber@uoguelph.ca
- Transgenic research.Transgenic Res.2013 Apr;22(2):379-89. doi: 10.1007/s11248-012-9646-7. Epub 2012 Sep 5.
- The genomic structure and generational stability of the transgene carried by the Cassie (CA) line of the transgenic Enviropig™, a prospective food animal, are reported here. This transgene is composed of the Escherichia coli phytase coding sequence regulated by the mouse parotid secretory protein
- PMID 22948309
- The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.
- Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ.SourceLaboratory for Molecular Biophysics, Physiology and Pharmacology, University of Antwerp, 2610 Antwerp, Belgium.
- The Journal of general physiology.J Gen Physiol.2013 Mar;141(3):359-69. doi: 10.1085/jgp.201210890. Epub 2013 Feb 11.
- Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine ciguatoxins potentiate Nav channels and cause ciguatera seafood poisoning. Several ciguatoxins have also been shown to affect Kv channels, and we show
- PMID 23401573
- Construction, Expression, and Characterization of Thymosin Alpha 1 Tandem Repeats in Escherichia coli.
- Xue XC, Yan Z, Li WN, Li M, Qin X, Zhang C, Hao Q, Wang ZL, Zhao N, Zhang W, Zhang YQ.SourceState Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
- BioMed research international.Biomed Res Int.2013;2013:720285. doi: 10.1155/2013/720285. Epub 2013 Feb 28.
- Thymosin alpha 1 (T α 1), which is composed of 28 amino acids, has been commercialized worldwide for its immune-modulatory and antitumor effects. T α 1 can stimulate T cell proliferation and differentiation from bone marrow stem cells, augment cell-mediated immune responses, and regulate homeostas
- PMID 23555093
Japanese Journal
- Virus analysis by electrophoresis on a microfluidic chip
- WEISS Victor U.,KOLIVOSKA Viliam,KREMSER Leopold,GAS Bohuslav,BLAAS Dieter,KENNDLER Ernst
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 860(2), 173-179, 2007-12-15
- NAID 10027467277
- Studies on Deoxynucleic Acids and Related Compounds. VI. Synthesis of Oligodeoxyribonucleotides containing Recognition Sequences for Restriction Endonucleases
- 大塚 栄子,柴原 進,池原 森男
- Chemical & pharmaceutical bulletin 30(4), 1307-1314, 1982-04-25
- … A possible concatemer structure of the decanucleotide duplex is suggested on the basis of its circular dichroism spectra in concentrated solution. …
- NAID 110003634437
- バクテリオファ-ジλの細胞内形成過程--電子顕微鏡観察によるその視覚化の試み
- 岡本 光正
- 生物物理 17(5), 254-266, 1977
- … By this new method, the presence of a complex consisting of precursor head and long DNA molecule (concatemer) can be clealy demonstrated in the host cells after infection of wild type phage. …
- NAID 130000723080
Related Links
- A concatemer is a long continuous DNA molecule that contains multiple copies of the same DNA sequences linked in series. These polymeric molecules are usually copies of an entire genome linked end to end and separated by cos sites (a ...
- concatenate To link structures together. Concatenating files appends one file to another. In speech synthesis, units of speech called 'phonemes' (k,
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コンカテマー
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- concatemer