補体C3-C5転換酵素
WordNet
- make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
- a complete number or quantity; "a full complement"
- one of a series of enzymes in the blood serum that are part of the immune response
- something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
- number needed to make up a whole force; "a full complement of workers" (同)full complement
- a word or phrase used to complete a grammatical construction
- either of two parts that mutually complete each other
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
PrepTutorEJDIC
- (あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
- carbonの化学記号
UpToDate Contents
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- 1. 補体経路complement pathways [show details]
… Another C3b binds to the C3 convertase to form C3bBbC3b, the C5 convertase. Thus, the binding of the second C3b shifts the substrate specificity from C3 to C5. Just as it stabilizes the C3 convertase, the binding …
- 2. C3糸球体腎症:デンスデポジット病およびC3糸球体腎炎c3 glomerulopathies dense deposit disease and c3 glomerulonephritis [show details]
… activity of the C3 convertase The serum protein, factor H, regulates the activity of the alternative pathway in the fluid phase by directly promoting the decay of the C3 and C5 convertases. Factor H also …
- 3. 補体系の制御因子および受容体regulators and receptors of the complement system [show details]
… pathway convertases. Factor H regulates C3b, C3b-containing alternative pathway convertases, and C5 convertases that contain either one C3b (from the complement pathway/lectin pathway) or two C3bs (alternative … The C3 convertases are powerful amplifiers of the complement system.…
- 4. 血液-血液透析膜の相互作用に関与する生化学的機序biochemical mechanisms involved in blood hemodialysis membrane interactions [show details]
…the activation of factor B by factor D, eventually resulting in formation of the C3 convertase C3bBb and the C5 convertase, which cleaves C5 to produce C5a, an anaphylatoxin, and C5b, which leads to generation …
- 5. 発作性夜間血色素尿症の病因pathogenesis of paroxysmal nocturnal hemoglobinuria [show details]
…of the C3 and C5 convertases upstream of MAC formation in the complement cascade. CD55 is normally attached to the RBC surface via a GPI anchor . CD55 protects RBCs from hemolysis by inhibiting C3 convertases …
English Journal
- Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations.
- Corvillo F, Okrój M, Nozal P, Melgosa M, Sánchez-Corral P, López-Trascasa M.
- Frontiers in immunology. 2019 ;10()886.
- Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either
- PMID 31068950
- Factor B and C4b2a Autoantibodies in C3 Glomerulopathy.
- Hauer JJ, Shao D, Zhang Y, Nester CM, Smith RJH.
- Frontiers in immunology. 2019 ;10()668.
- C3 Glomerulopathy (C3G) is a renal disease mediated primarily by dysregulation of the alternative pathway of complement. Complement is the cornerstone of innate immunity. It targets infectious microbes for destruction, clears immune complexes, and apoptotic cells from the circulation, and augments t
- PMID 31024533
- Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.
- Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.
- Cancer immunology, immunotherapy : CII. 2019 Apr;68(4)587-598.
- Anti-CD20 monoclonal antibodies (mAbs) rituximab and ofatumumab are potent activators of the classical complement pathway, and have been approved for the treatment of B-cell malignancies. However, complement exhaustion and overexpression of complement inhibitors by cancer cells diminish their therap
- PMID 30725204
Japanese Journal
- C3 nephritic factorの補体系に及ぼす影響 とくにC3bBbに対する安定化作用の検討:―とくにC3bBb対する安定化作用の検討―
- 中西 功
- 日本腎臓学会誌 23(6), 719-732, 1981
- … and C3 hemolytic activity were markedly reduced, while the other complement components activities, especially C5 activity, were within normal limits. … These sera showed high C3 nephritic factor (NeF) activities. … The purpose of this paper is to clarify the effect of NeF on the complemet system focusing the attention to the stabilizing effect of NeF on C3 convertase (C3bBb) activity. …
- NAID 130004168733
Related Links
- Definition: Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 ...
- Information on EC Information on EC 3.4.21.47 - alternative-complement- pathway C3/C5 convertase. ... alternative pathway of complement C3/C5 convertase, Homo sapiens, -, -, 707855. alternative-complement-pathway C3/C5 convertase ...
★リンクテーブル★
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- 英
- complement C3-C5 convertase
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代替経路補体C3-C5転換酵素
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古典経路補体C3-C5転換酵素
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- 同
- 補体第三成分 third component of complement
- 関
- 補体、C3a, C3b
- 補体の一つ
- C3は血清中に最も多く存在する
- C3 convertaseによってC3aとC3bを生じる
- C3 convertase活性を持つのは2つ
- 1. C4bC2a (古典的経路)
- 2. C3bBbP (別経路)
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- 補って完全にする物、補完物。(免疫)補体
- (必要な)全数、善良
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- 英
- complement 5, complement component 5
- 同
- 補体第五成分 fifth component of complement
- 関
- 補体
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補体C3、補体第三成分
- 関
- C3 complement、complement 3