WordNet

showing a fighting disposition; "highly competitive sales representative"; "militant in fighting for better wages for workers"; "his self-assertive and ubiquitous energy" (同)militant
involving competition or competitiveness; "competitive games"; "to improve ones competitive position" (同)competitory
subscribing to capitalistic competition (同)free-enterprise, private-enterprise
a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"

PrepTutorEJDIC

競争の,競争による
対立する人,敵対者,競争相手(opponent)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/14 04:13:09」(JST)

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A competitive antagonist is a receptor antagonist that binds to a receptor but does not activate the receptor. The antagonist will compete with available agonist for receptor binding sites on the same receptor. Sufficient antagonist will displace the agonist from the binding sites, resulting in a lower frequency of receptor activation.

Presence of a competitive antagonist will shift an agonism dose-response curve to the right.^[1] A Schild plot for a competitive antagonist will have a slope equal to 1, and the X-intercept and Y-intercept will each equal the dissociation constant of the antagonist.^[1]

Competitive antagonists are used to prevent the activity of drugs, and to reverse the effects of drugs that have already been consumed. Naloxone (also known as Narcan) is used to reverse opioid overdose caused by drugs such as heroin or morphine. Similarly, Ro15-4513 is an antidote to alcohol and flumazenil is an antidote to benzodiazepines.

A competitive antagonist can be reversible competitive antagonist or irreversible competitive antagonist.

References

^ ^a ^b Doseresponse curves in the presence of antagonists

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Japanese Journal

Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine

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Related Pictures

★リンクテーブル★

リンク元	「競合的拮抗剤」「競合的拮抗薬」「競合的遮断剤」「競合的遮断薬」
拡張検索	「noncompetitive antagonist」「non-competitive antagonist」
関連記事	「competitive」