同: Exosurf

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/01 17:02:11」(JST)

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1. 肺癌の化学予防 chemoprevention of lung cancer
2. 統合失調症に対する薬物療法：持効性抗精神病薬注射製剤 pharmacotherapy for schizophrenia long acting injectable antipsychotic drugs
3. 放射線性直腸炎の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of radiation proctitis
4. 口腔異形成および頭頸部癌における化学予防およびスクリーニング chemoprevention and screening in oral dysplasia and head and neck cancer
5. 網膜色素変性症：治療 retinitis pigmentosa treatment

English Journal

Interaction of prenylated chalcones and flavanones from common hop with phosphatidylcholine model membranes.

Wesołowska O1, Gąsiorowska J, Petrus J, Czarnik-Matusewicz B, Michalak K.Author information 1Department of Biophysics, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland. Electronic address: olga.wesolowska@umed.wroc.pl.AbstractCommon hop (Humulus lupulus) constitutes a source of numerous prenylated chalcones such as xanthohumol (XH) and flavanones such as 8-prenylnaringenin (8-PN) and isoxanthohumol (IXH). Range of their biological activities includes estrogenic, anti-inflammatory, anti-infective, anti-cancer, and antioxidant activities. The aim of the present work was to characterize the influence of prenylated polyphenols on model 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) membranes by means of differential scanning calorimetry (DSC), fluorescence and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopies. All studied compounds intercalated into DPPC bilayers and decreased its melting temperature as recorded by DSC, Laurdan and Prodan fluorescence, and ATR-FTIR. Polyphenols interacted mainly with glycerol backbone and acyl chain region of membrane. Magnitude of the induced effect correlated both with lipophilicity and molecular shape of the studied compounds. Elbow-shaped 8-PN and IXH were locked at polar-apolar region with their prenyl chains penetrating into hydrophobic part of the bilayer, while relatively planar XH molecule adopted linear shape that resulted in its deeper insertion into hydrophobic region. Additionally, by means of DSC and Laurdan fluorescence IXH was demonstrated to induce lateral phase separation in DPPC bilayers in gel-like state. It was assumed that IXH-rich and IXH-poor microdomains appeared within membrane. Present work constitutes the first experimental report describing interactions of prenylated hop polyphenols with phospholipid model membranes.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jan;1838(1 Pt B):173-84. doi: 10.1016/j.bbamem.2013.09.009. Epub 2013 Sep 21.
Common hop (Humulus lupulus) constitutes a source of numerous prenylated chalcones such as xanthohumol (XH) and flavanones such as 8-prenylnaringenin (8-PN) and isoxanthohumol (IXH). Range of their biological activities includes estrogenic, anti-inflammatory, anti-infective, anti-cancer, and antioxi
PMID 24060562

A liposome-based ion release impedance sensor for biological detection.

Damhorst GL1, Smith CE, Salm EM, Sobieraj MM, Ni H, Kong H, Bashir R.Author information 1Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, 208 N Wright St, Urbana, IL 61801, USA.AbstractLow-cost detection of pathogens and biomolecules at the point-of-care promises to revolutionize medicine through more individualized monitoring and increased accessibility to diagnostics in remote and resource-limited areas. While many approaches to biosensing are still limited by expensive components or inadequate portability, we present here an ELISA-inspired lab-on-a-chip strategy for biological detection based on liposome tagging and ion-release impedance spectroscopy. Ion-encapsulating dipalmitoylphosphatidylcholine (DPPC) liposomes can be functionalized with antibodies and are stable in deionized water yet permeabilized for ion release upon heating, making them ideal reporters for electrical biosensing of surface-immobilized antigens. We demonstrate the quantification of these liposomes by real-time impedance measurements, as well as the qualitative detection of viruses as a proof-of-concept toward a portable platform for viral load determination which can be applied broadly to the detection of pathogens and other biomolecules.
Biomedical microdevices.Biomed Microdevices.2013 Oct;15(5):895-905. doi: 10.1007/s10544-013-9778-4.
Low-cost detection of pathogens and biomolecules at the point-of-care promises to revolutionize medicine through more individualized monitoring and increased accessibility to diagnostics in remote and resource-limited areas. While many approaches to biosensing are still limited by expensive componen
PMID 23793417

Structural characterization of more potent alternatives to HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.

Nemashkalova EL1, Kazakov AS, Khasanova LM, Permyakov EA, Permyakov SE.Author information 1Institute for Biological Instrumentation of the Russian Academy of Sciences , Pushchino, Moscow region 142290, Russia.AbstractHAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA), and here we explore their structural features. The concentration dependencies of the tryptophan fluorescence of hLA, bLA, and bLG complexes with OA reveal their disintegration at protein concentrations below the micromolar level. Chemical cross-linking experiments provide evidence that association with OA shifts the distribution of oligomeric forms of hLA, bLA, bLG, and pPA toward higher-order oligomers. This effect is confirmed for bLA and bLG using the dynamic light scattering method, while pPA is shown to associate with OA vesicles. Like hLA binding, OA binding increases the affinity of bLG for small unilamellar dipalmitoylphosphatidylcholine vesicles, while pPA efficiently binds to the vesicles irrespective of OA binding. The association of OA with bLG and pPA increases their α-helix and cross-β-sheet content and resistance to enzymatic proteolysis, which is indicative of OA-induced protein structuring. The lack of excess heat sorption during melting of bLG and pPA in complex with OA and the presence of a cooperative thermal transition at the level of their secondary structure suggest that the OA-bound forms of bLG and pPA lack a fixed tertiary structure but exhibit a continuous thermal transition. Overall, despite marked differences, the HAMLET-like complexes that were studied exhibit a common feature: a tendency toward protein oligomerization. Because OA-induced oligomerization has been reported for other proteins, this phenomenon is inherent to many proteins.
Biochemistry.Biochemistry.2013 Sep 10;52(36):6286-99. doi: 10.1021/bi400643s. Epub 2013 Aug 27.
HAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA), and here we
PMID 23947814

Japanese Journal

Unilateral pulmonary interstitial emphysema and treatment with colfosceril palmitate

ABRAHAMSON EL
Lancet 341, 1603, 1993
NAID 30005836084

「exosurf」

Colfosceril palmitate
Systematic (IUPAC) name
	2,3-di(hexadecanoyloxy)propyl 2-trimethylazaniumylethyl phosphate
Clinical data
Trade names	Exosurf
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	63-89-8
ATC code	R07AA01 (WHO)
PubChem	CID 6138
ChemSpider	5908
UNII	319X2NFW0A
KEGG	D03585
ChEMBL	CHEMBL1200737
Synonyms	[2-({[2,3-bis(hexadecanoyloxy)propyl] phosphonato}oxy)ethyl]trimethylazanium
Chemical data
Formula	C40H80NO8P
Molar mass	734.039 g/mol
	SMILES O=C(OCC(OC(=O)CCCCCCCCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C)CCCCCCCCCCCCCCC ;
	InChI InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3 ; Key:KILNVBDSWZSGLL-UHFFFAOYSA-N ;
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