Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/23 05:18:06」(JST)

wiki en

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.^[1]

One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.^[2]^[3]

Interactions

Cofilin 1 has been shown to interact with HSPH1^[4] and LIMK1.^[5]^[6]

References

^ "Entrez Gene: CFL1 cofilin 1 (non-muscle)".
^ Chai X, Förster E, Zhao S, Bock HH, Frotscher M (January 2009). "Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3". J. Neurosci. 29 (1): 288–99. doi:10.1523/JNEUROSCI.2934-08.2009. PMID 19129405.
^ Frotscher M, Chai X, Bock HH, Haas CA, Förster E, Zhao S (April 2009). "Role of Reelin in the development and maintenance of cortical lamination". J Neural Transm 116 (11): 1451–5. doi:10.1007/s00702-009-0228-7. PMID 19396394.
^ Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
^ Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J (Sep 2003). "Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1". J. Cell Biol. 162 (6): 1089–98. doi:10.1083/jcb.200212060. PMC 2172847. PMID 12963706.
^ Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (Aug 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 先天性ミオパシー congenital myopathies

English Journal

Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA.

Pérez-Martínez FC, Carrión B, Lucío MI, Rubio N, Herrero MA, Vázquez E, Ceña V.SourceNanoDrugs, S.L. Parque Científico y Tecnológico, 02071 Albacete, Spain.
Biomaterials.Biomaterials.2012 Nov;33(32):8152-9. doi: 10.1016/j.biomaterials.2012.07.038. Epub 2012 Aug 2.
We synthesized a non-viral delivery system (f-CNH3) for small interfering RNA (siRNA) by anchoring a fourth-generation polyamidoamine dendrimer (G4-PAMAM) to carbon nanohorns (CNHs). Using this new compound, we delivered a specific siRNA designed to knockdown cofilin-1, a key protein in the regulati
PMID 22858003

Adipose tissue proteomes of intrauterine growth-restricted piglets artificially reared on a high-protein neonatal formula.

Sarr O, Louveau I, Le Huërou-Luron I, Gondret F.SourceINRA, UMR1079 Systèmes d'Elevage Nutrition Animale et Humaine, F-35590 Saint-Gilles, France; Agrocampus Ouest, UMR1079 Systèmes d'Elevage Nutrition Animale et Humaine, F-35000 Rennes, France.
The Journal of nutritional biochemistry.J Nutr Biochem.2012 Nov;23(11):1417-24. doi: 10.1016/j.jnutbio.2011.09.002. Epub 2012 Jan 4.
The eventuality that adipose tissues adapt to neonatal nutrition in a way that may program later adiposity or obesity in adulthood is receiving increasing attention in neonatology. This study assessed the immediate effects of a high-protein neonatal formula on proteome profiles of adipose tissues in
PMID 22221677

Japanese Journal

Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.

Fukumitsu Kansai,Fujishima Kazuto,Yoshimura Azumi,Wu You Kure,Heuser John,Kengaku Mineko
The Journal of neuroscience : the official journal of the Society for Neuroscience 35(14), 5707-5723, 2015-04-08
… Mechanistically, this energy depletion appears to perturb normal actin dynamics and enhance the aggregation of cofilin within growing dendrites, reminiscent of what occurs in neurons overexpressing the dephosphorylated form of cofilin. …
NAID 120005593705

Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding

Liu Ge,Xiang Yangfei,Guo Chaowan,Pei Ying,Wang Yifei,Kitazato Kaio
Biochemical and Biophysical Research Communications 453(4), 821-825, 2014-10-31
… In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. … Knock-down of cofilin-1 reduces viral yields. … These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding. …
NAID 120005522353

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Ohsawa Masahiro,Otake Saki,Murakami Tomoyasu [他]
Journal of pharmacological sciences 125(3), 292-299, 2014-07
NAID 40020129308

「コフィリン1」

CFL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BEX, 1Q8G, 1Q8X, 3J0S
Identifiers
Aliases	CFL1, CFL, HEL-S-15, cofilin
External IDs	OMIM: 601442 MGI: 101757 HomoloGene: 99735 GeneCards: 1072
Gene ontology
Molecular function	• protein binding; • actin binding;
Cellular component	• cytoplasm; • vesicle; • cell projection; • membrane; • cell-cell junction; • focal adhesion; • nuclear matrix; • plasma membrane; • intracellular; • ruffle membrane; • extracellular space; • cortical actin cytoskeleton; • actin cytoskeleton; • cytoskeleton; • lamellipodium membrane; • extracellular exosome; • cell nucleus;
Biological process	• neural fold formation; • response to amino acid; • Fc-gamma receptor signaling pathway involved in phagocytosis; • actin filament organization; • ephrin receptor signaling pathway; • actin filament depolymerization; • mitotic cytokinesis; • response to virus; • platelet degranulation; • blood coagulation; • negative regulation of apoptotic process; • axon guidance; • platelet activation; • protein phosphorylation; • positive regulation by host of viral process; • cytoskeleton organization; • neural crest cell migration; • Rho protein signal transduction; • establishment of cell polarity; • regulation of cell morphogenesis; • innate immune response; • regulation of dendritic spine morphogenesis; • positive regulation of actin filament depolymerization; • actin cytoskeleton organization;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	1072
	12631
	ENSG00000172757
	ENSMUSG00000056201
	P23528
	P18760
	NM_005507
	NM_007687
	NP_005498.1
	NP_031713.1
	Wikidata
View/Edit Human	View/Edit Mouse