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1. ヘリコバクターピロリ感染症の病態生理と免疫応答pathophysiology of and immune response to helicobacter pylori infection [show details]
…(PAI), including cytotoxin-associated gene A (CagA), coding for a 128 to 140 kd protein (CagA), coexpress VacA . VacA behaves as a passive urea transporter that is potentially capable of increasing the…
2. ヘリコバクターピロリ感染と十二指腸潰瘍の関連性association between helicobacter pylori infection and duodenal ulcer [show details]
…only strains with the cytotoxin-associated gene A (cagA), coding for a 128-140 kDa protein (CagA), coexpress vacuolating cytotoxin (VacA), a toxin that causes cell injury in vitro . Approximately 85 to 100…
3. 原発性免疫不全症の診断のためのフローサイトメトリーflow cytometry for the diagnosis of primary immunodeficiencies [show details]
…ALPS, the number of TCR alpha beta DNTs is increased Additionally, these TCR alpha beta DNT cells coexpress the B cell antigen B220. Evans syndrome has features of ALPS (eg, autoimmune cytopenias); therefore…
4. クリグラー・ナジャー症候群crigler najjar syndrome [show details]
…will be long enough to be useful in patients with Crigler-Najjar syndrome. Adenoviral vectors that coexpress UGT1A1 and an inhibitor of immune costimulation (eg, CTLA4Ig) can be administered repeatedly . The…
5. 急性骨髄性白血病の分子遺伝学molecular genetics of acute myeloid leukemia [show details]
…myelomonocytic and FAB-M5 monoblastic leukemias . Myeloid leukemias with 11q23 translocations often coexpress lymphoid markers, whereas 11q23 lymphoid leukemias often express myeloid or monocytoid markers in…

English Journal

Induction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine Production.

Costa PA1, Leoratti FM1, Figueiredo MM1, Tada MS2, Pereira DB2, Junqueira C1, Soares IS3, Barber DL4, Gazzinelli RT5, Antonelli LR1.
The Journal of infectious diseases.J Infect Dis.2015 Dec 15;212(12):1999-2010. doi: 10.1093/infdis/jiv306. Epub 2015 May 27.
The function and regulation of the immune response triggered during malaria is complex and poorly understood, and there is a particular paucity of studies conducted in humans infected with Plasmodium vivax. While it has been proposed that T-cell-effector responses are crucial for protection against
PMID 26019284

Identification of differentially expressed genes associated with burn sepsis using microarray.

Xu X1, Shi Z2, Hu J2, Yuan B2, Huang H1, Fang H1, Yin X1, Nie N1, Sheng X1.
International journal of molecular medicine.Int J Mol Med.2015 Dec;36(6):1623-9. doi: 10.3892/ijmm.2015.2374. Epub 2015 Oct 14.
The aim of the present study was to identify the potential target biomarkers associated with burn sepsis using microarray. GSE1781 was downloaded from Gene Expression Omnibus and included a collective of three biological replicates for each of the three conditions: Sham‑Sham, Sham‑cecal ligation
PMID 26498776

Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project.

Kim YH1, Tavallaee M2, Sundram U2, Salva KA2, Wood GS2, Li S2, Rozati S2, Nagpal S2, Krathen M2, Reddy S2, Hoppe RT2, Nguyen-Lin A2, Weng WK2, Armstrong R2, Pulitzer M2, Advani RH2, Horwitz SM2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2015 Nov 10;33(32):3750-8. doi: 10.1200/JCO.2014.60.3969. Epub 2015 Jul 20.
PURPOSE: In contrast to Hodgkin lymphoma and systemic anaplastic large-cell lymphoma, CD30 expression of malignant lymphocytes in mycosis fungoides (MF) and Sézary syndrome (SS) is quite variable. Clinical activity and safety of brentuximab vedotin, a CD30 targeting antibody-drug conjugate, was eva
PMID 26195720