WordNet

of or relating to the cochlea of the ear; "cochlear implant"
vein of the cochlear canal
the snail-shaped tube (in the inner ear coiled around the modiolus) where sound vibrations are converted into nerve impulses by the organ of Corti

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1. 成人における難聴の病因 etiology of hearing loss in adults
2. 小児における聴覚障害：病因 hearing impairment in children etiology
3. 老人性難聴 presbycusis
4. 遺伝性腎炎（アルポート症候群）の遺伝学、病因、および病理 genetics pathogenesis and pathology of hereditary nephritis alport syndrome
5. 耳の先天異常 congenital anomalies of the ear

PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.

Song Y1,2, Fan Z1, Bai X2,3, Liu W2,3, Han Y1, Xu L1, Wang M1, Li J2,3, Zheng Q4, Zhang D1, Wang H1,2,3.
Acta oto-laryngologica.Acta Otolaryngol.2016 Jun;136(6):545-50. doi: 10.3109/00016489.2016.1143968. Epub 2016 Mar 10.
Conclusion SM-induced dose- and location-dependent cochlear hair cell death in vitro. AIF might be translocated from mitochondria to nucleus and cytoplasm within SM-treated hair cells. The translocation of AIF might be modulated by PARP-1. Objective Streptomycin (SM), one of the widely used aminogly
PMID 26963167

Persistence, distribution, and impact of distinctly segmented microparticles on cochlear health following in vivo infusion.

Ross AM1,2, Rahmani S1,3, Prieskorn DM2, Dishman AF3,4, Miller JM2, Lahann J1,3,5, Altschuler RA2.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2016 Jun;104(6):1510-22. doi: 10.1002/jbm.a.35675. Epub 2016 Mar 2.
Delivery of pharmaceuticals to the cochleae of patients with auditory dysfunction could potentially have many benefits from enhancing auditory nerve survival to protecting remaining sensory cells and their neuronal connections. Treatment would require platforms to enable drug delivery directly to th
PMID 26841263

D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs.

Campbell KC1, Martin SM1, Meech RP1, Hargrove TL1, Verhulst SJ2, Fox DJ1.
International journal of audiology.Int J Audiol.2016 May;55(5):273-8. doi: 10.3109/14992027.2016.1143980. Epub 2016 Mar 10.
OBJECTIVE: Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose.DESIGN: Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six weeks after kanamycin and D-met a
PMID 26963517

Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae.

Nishimura Koji,Nakagawa Takayuki,Sakamoto Tatsunori,Ito Juichi
Cell transplantation 21(4), 763-771, 2012
… Four weeks after transplantation into the cochleae of neonatal mice, the number of surviving transplants of TTF-derived iPS cells generated by retroviral infection was significantly higher than those of MEF-derived iPS cells generated by plasmid transfection. … Teratoma formation was identified in one of five cochleae transplanted with TTF-derived iPS cells. …
NAID 120004057181

Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice.

Hamaguchi Kiyomi,Yamamoto Norio,Nakagawa Takayuki,Furuyashiki Tomoyuki,Narumiya Shuh,Ito Juichi
Neuropharmacology 62(4), 1841-1847, 2012
… EP4-deficient mice exhibited slight hearing loss and a reduction of distortion-product otoacoustic emissions (DPOAEs) with loss of outer hair cells (OHCs) in cochleae. … A significant increase of OHC loss was confirmed morphologically in the cochleae of EP4-deficient mice. …
NAID 120003874264

塚田佳子,今高城治,加納優治,市川剛,月舘利治,有阪治
Dokkyo journal of medical sciences 37(3), 201-205, 2010-10-25
人工内耳手埋込術を必要としたインフルエンザ桿菌による化膿性髄膜炎を報告した.症例は2 歳男児.感冒症状の5 日目に意識障害が出現し,化膿性髄膜炎と診断された.髄液培養検査で起因菌はインフルエンザ桿菌と判明した.莢膜血清型はb 型で,PBP-3 耐性遺伝子の変異を伴うgBLNAR と判明した.デキサメタゾン0.15 mg/kg×4×4 日,g グロブリン150 mg/kg×2 日,および抗生剤として …
NAID 110007873812