WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.

Fisher KW1, Das B1, Kim HS2, Clymer BK1, Gehring D1, Smith DR1, Costanzo-Garvey DL1, Fernandez MR1, Brattain MG3, Kelly DL1, MacMillan J4, White MA5, Lewis RE6.
Molecular and cellular biology.Mol Cell Biol.2015 Nov 15;35(22):3866-79. doi: 10.1128/MCB.00528-15. Epub 2015 Sep 8.
A major goal of cancer research is the identification of tumor-specific vulnerabilities that can be exploited for the development of therapies that are selectively toxic to the tumor. We show here that the transcriptional coactivators peroxisome proliferator-activated receptor gamma coactivator 1β
PMID 26351140

MicroRNA-761 regulates mitochondrial biogenesis in mouse skeletal muscle in response to exercise.

Xu Y1, Zhao C2, Sun X2, Liu Z3, Zhang J4.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 6;467(1):103-8. doi: 10.1016/j.bbrc.2015.09.113. Epub 2015 Sep 25.
MicroRNAs (miRNAs) have been suggested to play critical roles in skeletal muscle in response to exercise. Previous study has shown that miR-761 was involved in a novel model regulating the mitochondrial network. However, its role in mitochondrial biogenesis remains poorly understood. Therefore, the
PMID 26408907

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.

Kovács KA1, Steinmann M2, Halfon O3, Magistretti PJ4, Cardinaux JR5.
Cellular signalling.Cell Signal.2015 Nov;27(11):2252-60. doi: 10.1016/j.cellsig.2015.08.001. Epub 2015 Aug 4.
CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-interacting protein kinase 2 (HIPK2) in the r
PMID 26247811

Wei Ting,Li Jiayi,Sun Huiqiang,Jiang Mengyang,Yang Yun,Luo Xiayan,Liu Tingsong
Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ 61(3), 431-440, 2019
… By preparing the SLA titanium (Ti) plate (SLA Ti) and Polished Ti plate (Polished Ti), this experiment investigates the expression and distribution of the Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) in MC3T3-E1 cells. … The expression of YAP/TAZ increased in terms of mRNA and protein. … After silencing the integrin α1, α2, and β1 genes, YAP and TAZ decreased in terms of mRNA and protein. …
NAID 130007696177

Hajime Noda,Ryo Tamamura,Tetsuro Kono
International Journal of Oral-Medical Sciences 18(1), 74-85, 2019
… <p>Yes-associated protein(YAP)and transcriptional coactivator with PDZ-binding motif</p><p>(TAZ)are core components in development, homeostasis, and regeneration of tissues via the Hippo signaling pathway, which induces responses such as proliferation and apoptosis of cells. …
NAID 130007672342

Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells

Yang Liu,Jeong Kwang Won
Endocrine Journal 66(1), 65-74, 2019
… <p>The human homologue of flightless-I (FLII) belong to the gelsolin protein family and contain a gelsolin-like domain at the C-terminus and a leucine-rich repeat (LRR) domain at the N-terminus. … In protein binding assays, GR inhibited the E2-induced interaction between ERα and FLII, suggesting that GR interferes with the binding of ERα and FLII at the ERα target genes, resulting in the release of ERα and FLII from EREs. …
NAID 130007583530