Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/13 23:42:23」(JST)

Clofibride is a fibrate.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

English Journal

An in vitro release kinetic examination and comparative evaluation between submicron emulsion and polylactic acid nanocapsules of clofibride.

Magalhaes NS1, Fessi H, Puisieux F, Benita S, Seiller M.
Journal of microencapsulation.J Microencapsul.1995 Mar-Apr;12(2):195-205.
Polylactic acid nanocapsules of clofibride containing soybean oil (SO) or medium-chain triglycerides (MCT) as the oil core were prepared. The in-vitro drug release kinetic profiles were determined and compared to those of a clofibride submicron emulsion using two different kinetic techniques: the bu
PMID 7629662

[Effect of clofibride on the lipolysis of perirenal adipose tissue in hyperlipemic rabbits].

Elsair J, Marquie G, Tabet Aoul M, Dahmani Y, Tabet Aoul FS, Dufour P, Khelfat K, Iklef F, Ghouini A.
Comptes rendus des seances de la Societe de biologie et de ses filiales.C R Seances Soc Biol Fil.1982;176(2):146-50.
In hyperlipaemic rabbits (fat supply), perirenal adipose tissue lipolysis does not vary with one in vitro clofibride dose. After a 16 days pretreatment, one in vitro clofibride dose reduces the basal lipolysis and the lipolytic action of synacthene, and increases the antilipolytic effect of insulin.
PMID 6212099

Clofibride
Systematic (IUPAC) name
	3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
Clinical data
Legal status	?
Pharmacokinetic data
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Half-life	12 hours (clofibric acid)
Excretion	Renal (mostly) and fecal
Identifiers
CAS number	26717-47-5
ATC code	C10AB10
PubChem	CID 160134
ChemSpider	140758
UNII	0S9SLS3L93
KEGG	D07188
Chemical data
Formula	C16H22ClNO4
Mol. mass	327.803 g/mol
	SMILES Clc1ccc(OC(C(=O)OCCCC(=O)N(C)C)(C)C)cc1;
	InChI InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3 ; Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N ;
(what is this?) (verify)