clocortolone pivalate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/09 08:33:52」(JST)

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Clocortolone pivalate

Systematic (IUPAC) name
[2-(9-chloro-6-fluoro-11-hydroxy- 10,13,16-trimethyl- 3-oxo-7,8,11,12,14,15,16,17- octahydro- 6H-cyclopenta[a]phenanthren-17-yl)- 2-oxo-ethyl] 2,2-dimethylpropanoate
Clinical data
Trade names	Cloderm
AHFS/Drugs.com	Consumer Drug Information
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Topical
Identifiers
CAS number	34097-16-0 Y
ATC code	D07AB21
PubChem	CID 5282493
DrugBank	DB00838
ChemSpider	4445634 Y
UNII	QBL8IZH14X Y
KEGG	D02287 Y
ChEBI	CHEBI:59583 Y
ChEMBL	CHEMBL1201366 N
Chemical data
Formula	C27H36ClFO5
Mol. mass	495.023 g/mol
SMILES O=C(OCC(=O)[C@@H]3[C@]2(C[C@H](O)[C@]4(Cl)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C)C(C)(C)C
InChI InChI=1S/C27H36ClFO5/c1-14-9-16-17-11-19(29)18-10-15(30)7-8-26(18,6)27(17,28)21(32)12-25(16,5)22(14)20(31)13-34-23(33)24(2,3)4/h7-8,10,14,16-17,19,21-22,32H,9,11-13H2,1-6H3/t14-,16+,17+,19+,21+,22-,25+,26+,27+/m1/s1 Y Key:SXYZQZLHAIHKKY-GSTUPEFVSA-N Y
N (what is this?)  (verify)

Clocortolone (trade name Cloderm) is a topical steroid. It is used in the form of an ester, clocortolone pivalate, and applied as a cream.

References

English Journal

• Transitioning from brand to generic with topical products and the importance of maintaining the formulation and therapeutic profiles of the original product: focus on clocortolone pivalate 0.1% cream.

• Del Rosso JQ, Kircik LH.
• Journal of drugs in dermatology : JDD.J Drugs Dermatol.2014 Jul;13(7):s77-83.
• Topical corticosteroids (TCSs) are a major part of the foundation of treatment for a wide variety of eczematous and inflammatory skin disorders in both adults and children. Mid-potency TCSs represent an important category as they are often used to treat eczematous dermatoses, such as atopic dermatit
• PMID 25007376

• A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay.

• Kircik LH.
• Journal of drugs in dermatology : JDD.J Drugs Dermatol.2014 May;13(5):582-5.
• Dysfunction of the epidermal barrier is generally considered a precursor of cutaneous inflammation that can directly contribute to the pathogenesis of skin diseases, notably atopic dermatitis (AD). We also know that topical corticosteroids may actually impair the epidermal barrier by interfering wit
• PMID 24809882

• The role of a midpotency topical corticosteroid and the clinical relevance of formulation characteristics in the management of commonly encountered eczematous and inflammatory dermatoses in adults and children: focus on the pharmacologic properties of clocortolone pivalate 0.1% cream.

• Del Rosso JQ1, Kircik LH.
• Journal of drugs in dermatology : JDD.J Drugs Dermatol.2013 Feb;12(2):s5-s10.
• Midpotency topical corticosteroids (TCSs) are frequently used for the treatment of common eczematous and inflammatory skin disorders in both adults and children. There are several commercially available products in this category, and many vehicles and formulations for the clinician to choose from. C
• PMID 23377405

Related Links

• clocortolone pivalate topical : Uses, Side Effects, Interactions ...

Find patient medical information for clocortolone pivalate topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... This medication is used to treat a variety of skin conditions (e.g., ...

• Cloderm® Cream, 0.1% (clocortolone pivalate)

DESCRIPTION: Cloderm Cream 0.1% contains the medium potency topical corticosteroid, clocortolone pivalate, in a specially formulated water-washable emollient cream base consisting of purified water, white ...

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リンク元

「CLODERM」

「CLODERM」

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clocortolone pivalate