clinical pharmacology

• 臨床薬理学、臨床薬理

WordNet

1. a healthcare facility for outpatient care
2. a medical establishment run by a group of medical specialists
3. meeting for diagnosis of problems and instruction or remedial work in a particular activity
4. scientifically detached; unemotional; "he spoke in the clipped clinical monotones typical of police testimony"
5. relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients; "clinical observation"; "clinical case study"
6. the science or study of drugs: their preparation and properties and uses and effects (同)pharmacological medicine, materia_medica

PrepTutorEJDIC

1. 〈U〉(医学の)臨床講義 / 〈C〉《集合的に》臨床講義のクラス / 〈C〉臨床講義室 / 〈C〉(病院・医科大学・社会事業団などに付属した)診療所;《形容詞を判って》医療施設,病院 / 〈C〉(警察・学校・社会事業団などに付属した)相談所
2. 臨床の,臨床講義の / 病床の / 臨床的な,客観的な態度の
3. 薬学,薬物学,薬理学

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/06 04:09:26」(JST)

wiki en

[Wiki en表示]

Clinical pharmacology is the science of drugs and their clinical use. It is underpinned by the basic science of pharmacology, with added focus on the application of pharmacological principles and quantitative methods in the real world. It has a broad scope, from the discovery of new target molecules, to the effects of drug usage in whole populations.

Clinical pharmacology connects the gap between medical practice and laboratory science. The main objective is to promote the safety of prescription, maximise the drug effects and minimise the side effects. It is important that there be association with pharmacists skilled in areas of drug information, medication safety and other aspects of pharmacy practice related to clinical pharmacology. In fact, in countries such as USA, Netherlands and France, pharmacists train to become clinical pharmacologists. Therefore, clinical pharmacology is not specific to medicine.

Clinical pharmacologists usually have a rigorous medical and scientific training which enables them to evaluate evidence and produce new data through well designed studies. Clinical pharmacologists must have access to enough outpatients for clinical care, teaching and education, and research as well be supervised by medical specialists. Their responsibilities to patients include, but are not limited to analyzing adverse drug effects, therapeutics, and toxicology including reproductive toxicology, cardiovascular risks, perioperative drug management and psychopharmacology.

In addition, the application of genetic, biochemical, or virotherapeutical techniques has led to a clear appreciation of the mechanisms involved in drug action.

Branches

• Pharmacodynamics - finding out what drugs do to the body and how. This includes not just the cellular and molecular aspects, but also more relevant clinical measurements. For example, not just the biology of salbutamol, a beta2-adrenergic receptor agonist, but the peak flow rate of both healthy volunteers and real patients.
• Pharmacokinetics - what happens to the drug while in the body. This involves the body systems for handling the drug, usually divided into the following classification:
  • Absorption
  • Distribution
  • Metabolism
  • Excretion.
• Rational Prescribing - using the right medication, at the right dose, using the right route and frequency of administration for the patient, and stopping the drug appropriately.
• Adverse Drug Effects
• Toxicology
• Drug interactions
• Drug development - usually culminating in some form of clinical trial.

External links

• International Union of Basic and Clinical Pharmacology (IUPHAR)
• Dutch Society on Clinical Pharmacology and Biopharmaceutics (NVKF&B)
• American Society for Clinical Pharmacology and Therapeutics (ASCPT)
• American College of Clinical Pharmacology (ACCP)
• British Pharmacological Society (BPS)

UpToDate Contents

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English Journal

• Clinical pharmacology of paracetamol in neonates: a review.

• Pacifici GM1, Allegaert K2.
• Current therapeutic research, clinical and experimental.Curr Ther Res Clin Exp.2014 Dec 12;77:24-30. doi: 10.1016/j.curtheres.2014.12.001. eCollection 2015.
• Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates. Paracetamol clearance is lower in neonates than in children and adults. After metabolic conversion, paracetamol
• PMID 25709719

• Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance.

• Ayaz M1, Subhan F2, Ahmed J3, Khan AU4, Ullah F1, Ullah I5, Ali G2, Syed NI6, Hussain S7.
• Journal of biological research (Thessalonikē, Greece).J Biol Res (Thessalon).2015 Apr 16;22(1):4. doi: 10.1186/s40709-015-0028-1. eCollection 2015.
• BACKGROUND: Serotonin reuptake inhibitors were recently reported to possess antimicrobial potentials, potentiate activity of several antibiotics, reverse multidrug resistant phenotypes of bacteria and make them susceptible to previously resistant drugs. We investigated antimicrobial potentials of se
• PMID 26029671

• Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC-DAD.

• Brito SM1, Coutinho HD2, Talvani A3, Coronel C4, Barbosa AG1, Vega C4, Figueredo FG5, Tintino SR5, Lima LF5, Boligon AA6, Athayde ML6, Menezes IR7.
• Food chemistry.Food Chem.2015 Nov 1;186:185-91. doi: 10.1016/j.foodchem.2014.10.031. Epub 2014 Oct 17.
• The aim of this study was to evaluate the chemical profile and antioxidant, antimicrobial and antiparasitic activities of the hydroalcoholic extract of the leaves of Ziziphus joazeiro Mart. (HELZJ). The antioxidant DPPH and FRAP assays and chemical profile were determined by colorimetric methods and
• PMID 25976809

Japanese Journal

• Nosocomial infection and its molecular mechanisms of antibiotic resistance

• BioScience Trends advpub(0), 2016
• NAID 130005126205

• Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats

• Experimental Animals 65(1), 77-85, 2016
• NAID 130005125850

• 症例検討カンファレンス形式の静脈麻酔教育

• 日本臨床麻酔学会誌 36(1), 79-82, 2016
• NAID 130005125754

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★リンクテーブル★

リンク元	「臨床薬理」
関連記事	「clinical」「clinic」

「臨床薬理」

　　[★]

英

clinical pharmacology

関

臨床薬理学

「clinical」

　　[★]

• adj.

• 臨床の、臨床的な、臨床上の、クリニカル

関

clin、clinically

　 　 　

「clinic」

　　[★]

• n.

• クリニック、臨床講義、診療所