クリダナク
English Journal
- The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers.
- Kawai K, Shiojiri H, Fukushima H, Nozawa Y, Hasegawa J, Nozaki M, Tsurumi K, Fujimura H.
- Research communications in chemical pathology and pharmacology.Res Commun Chem Pathol Pharmacol.1984 Sep;45(3):399-406.
- The uncoupling activities of clidanac and its dechlorinated derivative on oxidative phosphorylation were examined using isolated rat liver mitochondria. Clidanac was found to uncouple the oxidative phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs. Dec
- PMID 6334337
- Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
- Boettcher I, Elger W, Kirsch G, Siegmund F, Wachtel H.
- Journal of medicinal chemistry.J Med Chem.1984 Mar;27(3):413-4.
- The preparation of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid is described. This acid has good anti-inflammatory and analgesic activities without producing irritation in the gastrointestinal tract up to the highest tested dose.
- PMID 6608000
- [The effects of various drugs on the binding site of bilirubin in serum albumin].
- Hasegawa J, Nozaki M, Fujimura H.
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.1984 Jan;83(1):79-83.
- In the presence of various drugs, the concentration of free bilirubin which was released from the first binding site of bilirubin in serum albumin was evaluated, using a sensitive method based on static fluorescence quenching of dansyl serum albumin. Bilirubin bound to human serum albumin more stron
- PMID 6714852
Japanese Journal
- Oxidative 1,2-aryl migration of alkyl aryl ketones by using diacetoxyphenyliodine: Syntheses of arylacetate, 2-arylpropanoate, and 2-arylsuccinate.
- 田村 恭光,矢倉 隆之,城内 善昭,春田 純一
- CHEMICAL & PHARMACEUTICAL BULLETIN 33(3), 1097-1103, 1985
- … The migration was successfully applied to the preparation of the antiinflammatory agents ibuprofen (15) and clidanac (17). …
- NAID 130003770112
- Oxidative 1,2-Aryl Migration of Alkyl Aryl Ketones by Using Diacetoxyphenyliodine : Syntheses of Arylacetate, 2-Arylpropanoate, and 2-Arylsuccinate
- 田村 恭光,矢倉 隆之,城内 善昭,春田 純一
- Chem. Pharm. Bull. 33, 1097-1103, 1985
- … The migration was successfully applied to the preparation of the antiinflammatory agents ibuprofen (15) and clidanac (17). …
- NAID 110003625489
- 血清アルブミンのビリルビン結合部位に対する薬物の影響
- 長谷川 順一,野崎 正勝,藤村 一
- 日本薬理学雑誌 83(1), 79-83, 1984
- … た.抗炎症薬のなかでfenamate類,allylphenyl propionic acid類は比較的強いビリルピン遊離作用を示し,flufenamic acidおよびketoprofenはヒト血清アルブミンからビリルビンを遊離した.indomethacinはほぼ無影響であったがclidanacはビリルビン結合部位に対し強い影響をあたえた.サルファ剤,抗生剤,warfarin,tolbutamide,phenytoinまたステロイド剤などはビリルビンを遊離しなかった.ここで用いた実験系は血清アルブミン上のビリルビ …
- NAID 130000760918