circumsporozoite

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Effect of thioredoxin peroxidase-1 gene disruption on the liver stages of the rodent malaria parasite Plasmodium berghei.

Usui M1, Masuda-Suganuma H2, Fukumoto S3, Angeles JM4, Hakimi H5, Inoue N6, Kawazu S7.
Parasitology international.Parasitol Int.2015 Jun;64(3):290-4. doi: 10.1016/j.parint.2014.09.013. Epub 2014 Oct 5.
Phenotypic observation of thioredoxin peroxidase-1 (TPx-1) gene-disrupted Plasmodium berghei (TPx-1 KO) in the liver-stage was performed with an in vitro infection system in order to investigate defective liver-stage development in a mouse infection model. Indirect immunofluorescence microscopy assa
PMID 25284813

Plasmodium falciparum: Genetic diversity and complexity of infections in an isolated village in western Thailand.

Tanabe K1, Zollner G2, Vaughan JA3, Sattabongkot J2, Khuntirat B2, Honma H4, Mita T5, Tsuboi T6, Coleman R7.
Parasitology international.Parasitol Int.2015 Jun;64(3):260-6. doi: 10.1016/j.parint.2013.09.011. Epub 2013 Sep 20.
Genetic diversity of Plasmodium falciparum is intimately associated with morbidity, mortality and malaria control strategies. It is therefore imperative to study genetic makeup and population structure of this parasite in endemic areas. In Kong Mong Tha, an isolated village in western Thailand, the
PMID 24060540

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals.

Hodgson SH1, Ewer KJ1, Bliss CM1, Edwards NJ1, Rampling T1, Anagnostou NA1, de Barra E2, Havelock T3, Bowyer G1, Poulton ID1, de Cassan S1, Longley R1, Illingworth JJ1, Douglas AD1, Mange PB1, Collins KA1, Roberts R1, Gerry S4, Berrie E5, Moyle S5, Colloca S6, Cortese R7, Sinden RE8, Gilbert SC1, Bejon P9, Lawrie AM1, Nicosia A10, Faust SN3, Hill AV1.
The Journal of infectious diseases.J Infect Dis.2015 Apr 1;211(7):1076-86. doi: 10.1093/infdis/jiu579. Epub 2014 Oct 21.
BACKGROUND: Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer of T-cells in humans, demonstrating si
PMID 25336730

False positivity of circumsporozoite protein (CSP)-ELISA in zoophilic anophelines in Bangladesh

Production of a Transgenic Mosquito Expressing Circumsporozoite Protein, a Malarial Protein, in the Salivary Gland of Anopheles stephensi (Diptera:Culicidae)