シプロフィブラート、シプロフィブレート
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/16 15:03:32」(JST)
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Ciprofibrate
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Systematic (IUPAC) name |
(RS)-2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-
methylpropanoic acid |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
? |
Identifiers |
CAS number |
52214-84-3 |
ATC code |
C10AB08 |
PubChem |
CID 2763 |
ChemSpider |
2661 Y |
UNII |
F8252JGO9S Y |
KEGG |
D03521 Y |
ChEBI |
CHEBI:50867 Y |
ChEMBL |
CHEMBL557555 Y |
Chemical data |
Formula |
C13H14Cl2O3 |
Mol. mass |
289.154 g/mol |
SMILES
- ClC2(Cl)CC2c1ccc(OC(C(=O)O)(C)C)cc1
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InChI
-
InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17) Y
Key:KPSRODZRAIWAKH-UHFFFAOYSA-N Y
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Y (what is this?) (verify) |
Ciprofibrate is a fibrate. Crystalline powder white or almost white. Melting point about 115 to 120°C.
Lipid modifying agents (C10)
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GI tract |
Cholesterol absorption inhibitors, NPC1L1
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Bile acid sequestrants/resins (LDL)
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- Cholestyramine
- Colestipol
- Colestilan
- Colextran
- Colesevelam
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Liver |
Statins (HMG-CoA reductase, LDL)
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- Simvastatin#
- Atorvastatin
- Fluvastatin
- Lovastatin
- Mevastatin
- Pitavastatin
- Pravastatin
- Rosuvastatin
- Cerivastatin‡
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Niacin and derivatives (HDL and LDL)
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- Niceritrol
- Niacin
- Nicofuranose
- Aluminium nicotinate
- Nicotinyl alcohol
- Acipimox
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MTTP inhibitors (VLDL)
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- Dirlotapide
- Lomitapide
- Mitratapide
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Blood vessels |
Fibrates (PPAR)
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- Clofibrate‡
- Bezafibrate
- Aluminium clofibrate
- Gemfibrozil
- Fenofibrate
- Simfibrate
- Ronifibrate
- Ciprofibrate
- Etofibrate
- Clofibride
- Clinofibrate
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CETP inhibitors (HDL)
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- Anacetrapib†
- Dalcetrapib§
- Evacetrapib§
- Torcetrapib†
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Combinations |
- Niacin/lovastatin
- Niacin/simvastatin
- Ezetimibe/simvastatin
- Ezetimibe/atorvastatin
- Niacin/laropiprant
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Other |
- Dextrothyroxine‡
- Probucol
- Tiadenol
- Benfluorex
- Meglutol
- Omega-3-triglycerides
- Magnesium pyridoxal 5-phosphate glutamate
- Policosanol
- Lapaquistat§
- Mipomersen
- Alipogene tiparvovec
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Primary hyperchylomicronemia syndrome treated with ciprofibrate in childhood.
- Lima-Martínez MM1, Piñango M2, Lima-Ostos M3.
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.Endocrinol Nutr.2016 Feb;63(2):98-99. doi: 10.1016/j.endonu.2015.10.006. Epub 2015 Dec 15.
- PMID 26704984
- Role of peroxisome proliferator-activated receptors alpha and gamma in gastric ulcer: An overview of experimental evidences.
- Saha L1.
- World journal of gastrointestinal pharmacology and therapeutics.World J Gastrointest Pharmacol Ther.2015 Nov 6;6(4):120-6. doi: 10.4292/wjgpt.v6.i4.120.
- Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Three subtypes, PPARα, PPARβ/δ, and PPARγ, have been identified so far. PPARα is expressed in the liver, kidney, small intestine, heart, and musc
- PMID 26558146
- Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels.
- Du WW1, Liu F2, Shan SW1, Ma XC1, Gupta S1, Jin T3, Spaner D4, Krylov SN5, Zhang Y6, Ling W7, Yang BB1.
- Molecular therapy : the journal of the American Society of Gene Therapy.Mol Ther.2015 Jul;23(7):1222-33. doi: 10.1038/mt.2015.64. Epub 2015 Apr 21.
- Steatosis is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD) which can be driven by peroxisome proliferator-activated receptor-α (PPAR-α) dysregulation. Through examining the effect of PPAR-α on fatty liver development, we found that PPAR-α is a targ
- PMID 25896250
Japanese Journal
- Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
- Achiral and chiral determination of ciprofibrate and its glucuronide in human urine by capillary electrophoresis
- HUTTEMANN Hendrik,BLASCHKE Gottfried
- Journal of chromatography. B, Biomedical sciences and applications 729(1), 33-41, 1999-06-11
- NAID 10024537539
- Inhibition of liver cell proliferation by dexamethasone does not prevent tumor induction by ciprofibrate in the rat liver
- RAO M. Sambasiva,SUBBARAO V.
- Hepatology research : the official journal of the Japan Society of Hepatology 12(1), 12-22, 1998-08-00
- NAID 10005911570
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