chloromercuribenzoate

クロロ第二水銀安息香酸

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/24 04:54:59」(JST)

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4-Chloromercuribenzoic acid

Names
IUPAC name (4-Carboxyphenyl)chloromercury
Other names p-Chloromercurybenzoic acid; p-Chloromercuribenzoate; 4-Chloromercuribenzoate
Identifiers
Abbreviations	PCMB
CAS Registry Number	59-85-8 Y
ChEBI	CHEBI:28420 Y
ChEMBL	ChEMBL575867 Y
ChemSpider	1667 Y
InChI InChI=1S/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1 Y Key: YFZOUMNUDGGHIW-UHFFFAOYSA-M Y InChI=1/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1/rC7H5ClHgO2/c8-9-6-3-1-5(2-4-6)7(10)11/h1-4H,(H,10,11) Key: YFZOUMNUDGGHIW-PSWPUYSSAS
Jmol-3D images	Image
PubChem	1730
SMILES O=C(O)c1ccc([Hg]Cl)cc1
Properties
Molecular formula	C7H5ClHgO2
Molar mass	357.16 g·mol−1
Melting point	287 °C (549 °F; 560 K) (dec.)
Hazards
R-phrases	R26/27/28 R33 R50/53
S-phrases	S13 S28 S36 S45 S60 S61
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Y verify (what is: Y/N?)
Infobox references

4-Chloromercuribenzoic acid (p-chloromercuribenzoic acid, PCMB) is an organomercury compound that is used as a protease inhibitor, especially in molecular biology applications.

PCMB reacts with thiol groups in proteins and is therefore an inhibitor of enzymes that are dependent on thiol reactivity, including cysteine proteases such as papain and acetylcholinesterase. Because of this reactivity with thiols, PCMB is also used in titrimetric quantification of thiol groups in proteins.

References

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• 1. 狂犬病の臨床的特徴および診断 clinical manifestations and diagnosis of rabies
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• 5. 癌患者における機能的問題 functional problems in the patient with cancer

English Journal

• [THE EFFECT OF METAL IONES AND SPECIFIC CHEMICAL REAGENTS ON THE ACTIVITY OF ASPERGILLUS FLAVUS VAR. ORYZAE AND BACILLUS SUBTILIS α-AMYLASES].

• Avdiyuk KV, Varbanets LD.
• Mikrobiolohichnyĭ zhurnal (Kiev, Ukraine : 1993).Mikrobiol Z.2015 Jul-Aug;77(4):15-24.
• The effect of cations and anions on the activity of Aspergillus flavus var. oryzae and Bacillus subtilis α-amylases showed that the tested enzymes are sensitive to most of cations and resistant to anions. The most significant inhibitory effects on the activity of A. flavus var. oryzae α-amylase ha
• PMID 26422920

• Morphology and water permeability of red blood cells from green sea turtle (Chelonia mydas).

• Benga G1, Chapman BE, Romeo T, Cox GC, Kuchel PW.
• Protoplasma.Protoplasma.2015 Jul;252(4):1181-5. doi: 10.1007/s00709-014-0747-4. Epub 2014 Dec 23.
• The morphology and diffusional water permeability (P d) of red blood cells (RBCs) from green sea turtle (GST) (Chelonia mydas) are presented for the first time. The RBCs had an ellipsoidal shape with full-axis lengths (diameters): D = 14.4 μm; d = 10.2 μm; h = 2.8 μm. The values of
• PMID 25534259

• Characterization of butyrate transport across the luminal membranes of equine large intestine.

• Nedjadi T1, Moran AW1, Al-Rammahi MA1, Shirazi-Beechey SP2.
• Experimental physiology.Exp Physiol.2014 Oct;99(10):1335-47. doi: 10.1113/expphysiol.2014.077982. Epub 2014 Aug 28.
• The diet of the horse, pasture forage (grass), is fermented by the equine colonic microbiota to short-chain fatty acids, notably acetate, propionate and butyrate. Short-chain fatty acids provide a major source of energy for the horse and contribute to many vital physiological processes. We aimed to
• PMID 25172888

Japanese Journal

• Enhancement of Pressure-Induced Hemolysis by Aquaporin-1 Inhibitors in Human Erythrocytes

• Bulletin of the Chemical Society of Japan 85(4), 497-503, 2012
• NAID 130004153050

• Reinvestigation of Drugs and Chemicals as Aquaporin-1 Inhibitors Using Pressure-Induced Hemolysis in Human Erythrocytes

• Biological and Pharmaceutical Bulletin 35(11), 2088-2091, 2012
• NAID 130001872270

• Organomercurials removal by heterogeneous merB genes harboring bacterial strains(ENVIRONMENTAL BIOTECHNOLOGY)

• Journal of bioscience and bioengineering 110(1), 94-98, 2010-07
• NAID 110007681451

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• The effects of p-chloromercuribenzoate on muscarinic ...

Aronstam RS, Abood LG, Hoss W. Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain. Mol Pharmacol. 1978 Jul; 14 (4):575–586. [PubMed] Aronstam RS ...

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