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a sweet tasting alkaloid that occurs in sugar beets

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クロラール(DDTに用いる)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/10 19:35:39」(JST)

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Chloral betaine (USAN, BAN) (brand names Beta-Chlor, Somilan), also known as cloral betaine (INN), is a sedative-hypnotic drug.^[1]^[2]^[3]^[4] It was introduced by Mead Johnson in the United States in 1963.^[5] It is a betaine complex with chloral hydrate, which acts as an extended-acting formulation of chloral hydrate which is then metabolized into trichloroethanol, which is responsible for most or all of its effects.^[3]^[4]^[6]

References

^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1231–. ISBN 978-1-4757-2085-3.
^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 72–. ISBN 978-94-011-4439-1.
^ ^a ^b Ellen L. Bassuk; Stephen C. Schoonover; Alan J. Gelenberg (6 December 2012). The Practitioner's Guide to Psychoactive Drugs. Springer Science & Business Media. pp. 208–. ISBN 978-1-4615-8049-2.
^ ^a ^b W. Lowry (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 157–. ISBN 978-1-4684-3444-6.
^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 944–. ISBN 978-0-8155-1856-3.
^ George Morrison Maxwell (6 December 2012). Principles of Paediatric Pharmacology. Springer Science & Business Media. pp. 124–. ISBN 978-1-4684-7544-9.

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1. 小児に対する手術室外での鎮静処置に使用する薬剤 pharmacologic agents for pediatric procedural sedation outside of the operating room
2. 成人における非アルコール性脂肪肝疾患の自然経過およびマネージメント natural history and management of nonalcoholic fatty liver disease in adults
3. 成人における急性ストレス障害の治療 treatment of acute stress disorder in adults
4. 小児に対する手術室外での鎮静処置に使用する薬剤の選択 selection of medications for pediatric procedural sedation outside of the operating room
5. MRI検査やCT検査で行う麻酔 anesthesia for magnetic resonance imaging and computed tomography procedures

English Journal

Anesthetics block morphine-induced increases in serotonin release in rat CNS.

Tao R1, Auerbach SB.
Synapse (New York, N.Y.).Synapse.1994 Dec;18(4):307-14.
The effect of morphine on serotonin (5-HT) was examined by microdialysis in unanesthetized and anesthetized rats. In unanesthetized rats, morphine (10 mg/kg, s.c.) produced increases in extracellular 5-HT in nucleus accumbens (n. accumbens) and dorsal raphe nucleus (DRN), but not in the dorsal hippo
PMID 7886623

Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde.

Dockham PA1, Lee MO, Sladek NE.
Biochemical pharmacology.Biochem Pharmacol.1992 Jun 9;43(11):2453-69.
Biotransformation of the biologically and pharmacologically important aldehydes, retinaldehyde and aldophosphamide, is mediated, in part, by NAD(P)-dependent aldehyde dehydrogenases catalyze the oxidation of the aldehydes to their respective acids, retinoic acid and carboxyphosphamide. Not known at
PMID 1610409

Oral and rectal absorption of chloral hydrate and its betaine complex.

Simpson M, Parrott EL.
Journal of pharmaceutical sciences.J Pharm Sci.1980 Feb;69(2):227-8.
Chloral hydrate and its betaine complex was administered orally and rectally to nine healthy male subjects. The urinary excretion, which was a reflection of absorption, of a metabolite, trichloroacetic acid, was determined. No statistically significant difference was found between the oral absorptio
PMID 7359335

「クロラールベタイン」

Chloral betaine
Systematic (IUPAC) name
	2,2,2-Trichloro-1,1-ethanediol : (trimethylammonio)acetate (1:1)
Clinical data
Routes of; administration	Oral
Legal status
Legal status	US: Schedule IV;
Identifiers
CAS Number	2218-68-0
ATC code	None
PubChem	CID 16676
DrugBank	DB01494
ChemSpider	15813
Chemical data
Formula	C7H14Cl3NO4
Molar mass	281.541 g/mol
	SMILES C[N+](C)(C)CC(=O)[O-].C(C(Cl)(Cl)Cl)(O)O ;
	InChI InChI=1S/C5H11NO2.C2H3Cl3O2/c1-6(2,3)4-5(7)8;3-2(4,5)1(6)7/h4H2,1-3H3;1,6-7H ; Key:ONAOIDNSINNZOA-UHFFFAOYSA-N ;

　　[★]

英: chloral betaine
同: ベタインクロラール

[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1231–. ISBN 978-1-4757-2085-3.

[MortonHall2012-2] I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 72–. ISBN 978-94-011-4439-1.

[BassukSchoonover2012-3] Ellen L. Bassuk; Stephen C. Schoonover; Alan J. Gelenberg (6 December 2012). The Practitioner's Guide to Psychoactive Drugs. Springer Science & Business Media. pp. 208–. ISBN 978-1-4615-8049-2.

[Lowry2012-4] W. Lowry (6 December 2012). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. pp. 157–. ISBN 978-1-4684-3444-6.

[Publishing2013-5] William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 944–. ISBN 978-0-8155-1856-3.

[Maxwell2012-6] George Morrison Maxwell (6 December 2012). Principles of Paediatric Pharmacology. Springer Science & Business Media. pp. 124–. ISBN 978-1-4684-7544-9.

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案内

chloral betaine