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English Journal

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.

Metcalf TU1, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK.
Aging cell.Aging Cell.2015 Jun;14(3):421-32. doi: 10.1111/acel.12320. Epub 2015 Feb 27.
Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains in
PMID 25728020

Sulcova J1, Meyer M1, Guiducci E1, Feyerabend TB2, Rodewald HR2, Werner S3.
The American journal of pathology.Am J Pathol.2015 Jun;185(6):1575-87. doi: 10.1016/j.ajpath.2015.02.005. Epub 2015 Apr 3.
Chronic inflammatory skin diseases, such as atopic dermatitis, affect a large percentage of the population, but the role of different immune cells in the pathogenesis of these disorders is largely unknown. Recently, we found that mice lacking fibroblast growth factor receptor 1 (Fgfr1) and Fgfr2 (K5
PMID 25843682

FABP4 inhibition suppresses PPARγ activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages.

Boß M1, Kemmerer M1, Brüne B1, Namgaladze D2.
Atherosclerosis.Atherosclerosis.2015 Jun;240(2):424-30. doi: 10.1016/j.atherosclerosis.2015.03.042. Epub 2015 Apr 3.
OBJECTIVE: Macrophages, converted to lipid-loaded foam cells, accumulate in atherosclerotic lesions. Macrophage lipid metabolism is transcriptionally regulated by peroxisome proliferator-activated receptor gamma (PPARγ), and its target gene fatty acid binding protein 4 (FABP4) accelerates the progr
PMID 25897794

Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors

Oshima Hiroko,Hioki Kyoji,Popivanova Boryana K.,Oguma Keisuke,Rooijen Nico van,Ishikawa Tomoo,Oshima Masanobu
Gastroenterology 140(2), 596-607, 2011-02
… PGE2 signaling and bacterial infection or stimulation with lipopolysaccharide induced expression of the chemokine C-C motif ligand 2 (CCL2) (which attracts macrophage) in tumor stromal cells or cultured macrophages, respectively. … CCL2 inhibition suppressed macrophage infiltration in tumors, and depletion of macrophages from the tumors of Gan mice led to signs of tumor regression. … they cooperate to up-regulate CCL2, which recruits macrophage to gastric tumors. …
NAID 120002829318

Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice

Kakinoki Kaheita,Nakamoto Yasunari,Kagaya Takashi,Tsuchiyama Tomoya,Sakai Yoshio,Nakahama Tohru,Mukaida Naofumi,Kaneko Shuichi
Journal of Gene Medicine 12(12), 1002-1013, 2010-12
… a mouse model of intrahepatic metastasis, we investigated whether chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) could potentiate the antitumor effects of the herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) system.Methods: Mouse hepatoma cells infected with recombinant adenovirus vectors expressing HSV-tk, CCL2/MCP-1 and LacZ at multiplicities of infection of Ad-tk/Ad-MCP1 = 3/0.03 (T/MLow), 3/3 (T/MHigh) and Ad-tk/Ad-LacZ = 3/3 (T/L) were injected into BALB/c …
NAID 120003141442