WordNet

of or made from or using substances produced by or used in reactions involving atomic or molecular changes; "chemical fertilizer"
material produced by or used in a reaction involving changes in atoms or molecules (同)chemical substance
relating to or used in chemistry; "chemical engineer"; "chemical balance" (同)chemic
any agent (physical or environmental) that can induce a genetic mutation or can increase the rate of mutation

PrepTutorEJDIC

『化学の』,化学上の;化学的な,化学作用による / 化学薬品の,化学薬品を用いる / 『化学薬品』(『製品』)

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1. 抜爪および化学的爪切除術nail avulsion and chemical matricectomy [show details]
…typically epithelializes within 7 to 10 days. Chemical matricectomy is the chemical ablation of all or part of the nail matrix. The rationale for chemical matricectomy is to destroy the matrix to prevent …
2. 化学テロ：早急な認識および初回薬物治療マネージメントchemical terrorism rapid recognition and initial medical management [show details]
… Stockpiling and Use of Chemical Weapons and on Their Destruction, or Chemical Weapons Convention (CWC), has been in force. The CWC is administered by the Organisation for the Prohibition of Chemical Weapons (OPCW) …
3. 局所の化学熱傷：初期評価およびマネージメントtopical chemical burns initial assessment and management [show details]
…with a focus on the basic principles of management. Thermal burns, chemical ingestions, chemical eye injuries, and agents used for chemical warfare are discussed elsewhere. The potency and concentration …
4. 特発性環境不耐症（多種類化学物質過敏症）idiopathic environmental intolerance multiple chemical sensitivity [show details]
…of a concept called “chemical intolerance,” and individuals with chemical intolerance also appear to have stable symptoms. A general population study identified people with chemical intolerance based upon …
5. 急性骨髄性白血病の病因pathogenesis of acute myeloid leukemia [show details]
…occupation and chemicals have generally been less than twofold . The presence of RAS mutations in patients with AML has been associated with specific occupational exposure to chemicals,… RUNX1/RUNX1T1 were healthy throughout their lifespan, developing AML only after exposure to an alkylating mutagen , or in cooperation with Wilms tumor gene (WT1) overexpression . Remission bone marrow samples from …

English Journal

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9.

Yauk CL1, Buick JK1, Williams A1, Swartz CD2, Recio L2, Li HH3,4, Fornace AJ Jr3,4, Thomson EM1, Aubrecht J5.
Environmental and molecular mutagenesis.Environ Mol Mutagen.2016 May;57(4):243-60. doi: 10.1002/em.22004. Epub 2016 Mar 4.
In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not expr
PMID 26946220

p53 coordinates base excision repair to prevent genomic instability.

Poletto M1, Legrand AJ1, Fletcher SC1, Dianov GL2.
Nucleic acids research.Nucleic Acids Res.2016 Apr 20;44(7):3165-75. doi: 10.1093/nar/gkw015. Epub 2016 Jan 14.
DNA constantly undergoes chemical modification due to endogenous and exogenous mutagens. The DNA base excision repair (BER) pathway is the frontline mechanism handling the majority of these lesions, and primarily involves a DNA incision and subsequent resealing step. It is imperative that these proc
PMID 26773055

Leaf extracts from Teucrium ramosissimum protect against DNA damage in human lymphoblast cell K562 and enhance antioxidant, antigenotoxic and antiproliferative activity.

Sghaier MB1, Ismail MB2, Bouhlel I3, Ghedira K3, Chekir-Ghedira L4.
Environmental toxicology and pharmacology.Environ Toxicol Pharmacol.2016 Apr 14;44:44-52. doi: 10.1016/j.etap.2016.04.006. [Epub ahead of print]
The in vitro antioxidant, antigenotoxic and antiproliferative activities of Teucrium ramosissimum extracts were investigated. The antioxidant activities of the tested extracts were evaluated through three chemical assays: The Cupric reducing antioxidant capacity, the reducing power and the ferric re
PMID 27105156

Japanese Journal

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Sonohara Yuina,Yamamoto Junpei,Tohashi Kosuke,Takatsuka Reine,Matsuda Tomonari,Iwai Shigenori,Kuraoka Isao
Scientific reports (9), 2019-01-24
… However, the chemical structure of tumorigenic DNA lesions formed by acetaldehyde remains unknown, although it has long been considered an environmental mutagen in alcohol, tobacco, and food. …
NAID 120006552922

化学物質の生殖細胞変異原性と次世代影響

増村健一
日本毒性学会学術年会 44.1(0), S6-1, 2017
遺伝子突然変異は、様々なDNA損傷（鎖切断、脱塩基、修飾等）が不完全なDNA修復やDNAポリメラーゼの複製エラーを経て、遺伝情報が書き換えられることによって生じる。体細胞突然変異はがんの原因となり、生殖細胞突然変異は次世代個体に遺伝して遺伝性疾患等の要因となる。近年、次世代シークエンサー(NGS)を用いたヒトゲノム配列の大規模解析が行われるようになり、様々な疾患と関連する遺伝子変異が発見されている …
NAID 130006582364

Ethyl methanesulfonate によって誘導されたショウロの好塩性菌株の分離

高琪,仲野翔太,會見忠則,霜村典宏
日本きのこ学会誌 24(4), 182-186, 2016
ショウロは世界に広く分布する外生菌根菌である．近年，本きのこ種において交雑技術を用いることで耐塩性ショウロ菌株を育成できることが報告されている．しかしながら，変異誘発剤を用いて耐塩性系統を分離した変異実験は実施されていないのが現状である．本研究では，変異誘発剤として広く用いられているethyl methanesulfonate (EMS) を用いて変異誘発を試みた．EMS を処理したショウロの担子 …
NAID 130007487809