目次
WordNet
- a soft yellow wax secreted by glands in the ear canal (同)earwax
PrepTutorEJDIC
- 耳あか
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/07 20:46:11」(JST)
wiki en
| Earwax | |
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Wet-type human earwax
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| Classification and external resources | |
| Pronunciation | cerumen /səˈruːmɛn/ |
| Specialty | Otorhinolaryngology |
| MedlinePlus | 000979 |
| Patient UK | Earwax |
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[edit on Wikidata]
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Earwax, also known as cerumen, is a yellowish waxy substance secreted in the ear canal of humans and other mammals. It protects the skin of the human ear canal, assists in cleaning and lubrication, and also provides some protection against bacteria, fungi, insects and water.[1]
Earwax consists of shed skin cells, hair, and the secretions of the ceruminous and sebaceous glands of the outside ear canal.[2] Major components of earwax are long chain fatty acids, both saturated and unsaturated, alcohols, squalene, and cholesterol.[2] Excess or compacted cerumen can press against the eardrum or block the outside ear canal or hearing aids, potentially causing hearing loss.
Contents
- 1 Physiology
- 1.1 Cleaning
- 1.2 Lubrication
- 1.3 Antimicrobial effects
- 2 Excess earwax
- 3 Removal
- 3.1 Softeners
- 3.2 Ear irrigation
- 3.3 Curette and cotton swabs
- 3.4 Ear candles and vacuuming
- 3.5 Potential complications
- 4 History
- 4.1 Uses
- 5 Other animals
- 6 References
- 7 Further reading
- 8 External links
Physiology
Earwax
Wet-type human earwax on a cotton swab
Dry-type earwax
Cerumen is produced in the outer third of the cartilaginous portion of the ear canal. It is a mixture of viscous secretions from sebaceous glands and less-viscous ones from modified apocrine sweat glands.[3] The primary components of earwax are shed layers of skin, with , on average, 60% of the earwax consisting of keratin, 12–20% saturated and unsaturated long-chain fatty acids, alcohols, squalene and 6–9% cholesterol.[4]
There are two distinct genetically determined types of earwax: the wet type, which is dominant, and the dry type, which is recessive. While Asians and Native Americans are more likely to have the dry type of cerumen (gray and flaky), African and European people are more likely to have the wet type (honey-brown to dark-brown and moist).[5] Cerumen type has been used by anthropologists to track human migratory patterns, such as those of the Eskimos.[6] In Japan, wet-type earwax is more prevalent among the Ainu, in contrast to that country's Yamato majority.[7] The consistency of wet type earwax is due to the higher concentration of lipid and pigment granules (50% lipid) in the substance than the dry type (30% lipid).[4][verification needed]
A specific gene has been identified that determines whether people have wet or dry earwax.[8] The difference in cerumen type has been tracked to a single base change (a single nucleotide polymorphism) in a gene known as "ATP-binding cassette C11 gene".[9] Dry-type individuals are homozygous for adenine whereas wet-type requires at least one guanine. Wet-type earwax is associated with armpit odor, which is increased by sweat production. The researchers conjecture that the reduction in sweat or body odor was beneficial to the ancestors of East Asians and Native Americans who are thought to have lived in cold climates.[10]
Cleaning
Cleaning of the ear canal occurs as a result of the "conveyor belt" process of epithelial migration, aided by jaw movement.[11] Cells formed in the centre of the tympanic membrane migrate outwards from the umbo (at a rate comparable to that of fingernail growth) to the walls of the ear canal, and move towards the entrance of the ear canal. The cerumen in the canal is also carried outwards, taking with it any particulate matter that may have gathered in the canal. Jaw movement assists this process by dislodging debris attached to the walls of the ear canal, increasing the likelihood of its expulsion.
Lubrication
The lubrication provided by cerumen prevents desiccation of the skin within the ear canal. The lubricative properties arise from the high lipid content of the sebum produced by the sebaceous glands. In wet-type cerumen at least, these lipids include cholesterol, squalene, and many long-chain fatty acids and alcohols.[12][13]
Antimicrobial effects
While studies conducted up until the 1960s found little evidence supporting antibacterial activity for cerumen,[14] more recent studies have found that cerumen has a bactericidal effect on some strains of bacteria. Cerumen has been found to reduce the viability of a wide range of bacteria, including Haemophilus influenzae, Staphylococcus aureus, and many variants of Escherichia coli, sometimes by as much as 99%.[15][16] The growth of two fungi commonly present in otomycosis was also significantly inhibited by human cerumen.[17] These antimicrobial properties are due principally to the presence of saturated fatty acids, lysozyme and, especially, to the slight acidity of cerumen (pH typically around 6.1 in normal individuals[18]). Conversely, other research has found that cerumen can support microbial growth and some cerumen samples were found to have bacterial counts as high as 107/g cerumen.[19]
Excess earwax
Excessive earwax may impede the passage of sound in the ear canal, causing conductive hearing loss. Hearing aids may be associated with increased earwax impaction.[20] It is also estimated to be the cause of 60–80% of hearing aid faults.[21]
Removal
Movement of the jaw helps the ears' natural cleaning process. The American Academy of Otolaryngology discourages earwax removal unless excess earwax is causing health problems.[22] While a number of methods of earwax removal are effective, their comparative merits have not been determined.[23] A number of softeners are effective; however, if this is not sufficient,[23] the most common method of cerumen removal is syringing with warm water.[24] A curette method is more likely to be used by otolaryngologists when the ear canal is partially occluded and the material is not adhering to the skin of the ear canal. Cotton swabs, on the other hand, push most of the earwax farther into the ear canal and remove only a small portion of the top layer of wax that happens to adhere to the fibers of the swab.[25]
Softeners
This process is referred to as cerumenolysis. A review of studies found that topical preparations for the removal of earwax may be better than no treatment, and there may not be much difference between types, including water and olive oil.[26] However, there were not enough studies to draw firm conclusions, and the evidence on irrigation and manual removal is equivocal.[26]
Commercially or commonly available cerumenolytics include:[27]
- Any of a number of types of oil
- Urea hydrogen peroxide (6.5%) and glycerine
- A solution of sodium bicarbonate in water, or sodium bicarbonate B.P.C. (sodium bicarbonate and glycerine)
- Cerumol (peanut oil, turpentine and dichlorobenzene)
- Cerumenex (triethanolamine, polypeptides and oleate-condensate)
- Docusate, an emulsifying agent, an active ingredient found in laxatives
A cerumenolytic should be used 2–3 times daily for 3–5 days prior to the cerumen extraction.[28]
Ear irrigation
Once the cerumen has been softened, it may be removed from the ear canal by irrigation, but the evidence on this practice is equivocal.[26] This may be effectively accomplished with a spray type ear washer, commonly used in the medical setting or at home, or with a bulb syringe at home.[29] Ear syringing techniques are described in great detail by Wilson & Roeser,[28] and Blake et al.,[30] who advise pulling the external ear up and back, and aiming the nozzle of the syringe slightly upwards and backwards so that the water flows as a cascade along the roof of the canal. The irrigation solution flows out of the canal along its floor, taking wax and debris with it. The solution used to irrigate the ear canal is usually warm water,[30] normal saline,[31] sodium bicarbonate solution,[32] or a solution of water and vinegar to help prevent secondary infection.[30]
Patients generally prefer the irrigation solution to be warmed to body temperature,[31] as dizziness is a common side effect of ear washing or syringing with fluids that are colder or warmer than body temperature.ref name=Sharp/>[30]
Curette and cotton swabs
Earwax can be removed with an ear pick/curette, which physically dislodges the earwax and scoops it out of the ear canal.[33] In the west, use of ear picks is usually only done by health professionals; a modified curette having a safety stop to prevent deep insertion for self-use is available. Curetting earwax using an ear pick was common in ancient Europe and still practiced in East Asia. Since the earwax of most Asians is of the dry type,[5] it is extremely easily removed by light scraping with an ear pick, as it simply falls out in large pieces or dry flakes.
It is generally advised not to use cotton swabs (Q-Tips or cotton buds), as doing so will likely push the wax farther down the ear canal, and if used carelessly, perforate the eardrum.[25] Abrasion of the ear canal, particularly after water has entered from swimming or bathing, can lead to ear infection. Also, the cotton head may fall off and become lodged in the ear canal. Therefore, cotton swabs should be used only to clean the external ear.
Ear candles and vacuuming
Ear candling, also called ear coning or thermal-auricular therapy, is an alternative medicine practice claimed to improve general health and well-being by lighting one end of a hollow candle and placing the unlit end in the ear canal. According to medical researchers, it is both dangerous and ineffective.[34] Advocates say that the dark residue that shows after the procedure consists of extracted earwax, proving the efficacy of the procedure. Studies have shown that in fact the same dark residue is left, whether or not the candle (which is made of cotton fabric and beeswax and leaves a residue after burning) is inserted into an ear. This demonstrates that the waxy residue is derived from the candle itself and not the ear. The color of the candle wax matches the light brown-colored wax of the human ear, making the distinction between the two waxes more difficult for a layperson. Because the candle itself is a hollow tube, some of the hot burnt wax could drop down inside the candle, into the ear canal, potentially injuring the eardrum. The American Academy of Otolaryngology states that ear candles are not a safe option for removing ear wax, and that no controlled studies or scientific evidence support their use for ear wax removal.[35] The Food and Drug Administration has successfully taken several regulatory actions against the sale and distribution of ear candles since 1996, including seizing ear candle products and ordering injunctions.[35]
Home "ear vacs" were ineffective at removing ear-wax, especially when compared to a Jobson-Horne probe.[36]
Potential complications
A postal survey of British general practitioners[24] found that only 19% always performed cerumen removal themselves. It is problematic as the removal of cerumen is not without risk, and physicians and nurses often have inadequate training for removal. Irrigation can be performed at home with proper equipment as long as the person is careful not to irrigate too hard. All other methods should only be carried out by individuals who have been sufficiently trained in the procedure.
The author Bull advised physicians: "After removal of wax, inspect thoroughly to make sure none remains. This advice might seem superfluous, but is frequently ignored."[32] This was confirmed by Sharp et al.,[24] who, in a survey of 320 general practitioners, found that only 68% of doctors inspected the ear canal after syringing to check that the wax was removed. As a result, failure to remove the wax from the canal made up approximately 30% of the complications associated with the procedure. Other complications included otitis externa (swimmer's ear), which involves inflammation or bacterial infection of the external acoustic meatus, as well as pain, vertigo, tinnitus, and perforation of the ear drum. Based on this study, a rate of major complications in 1/1000 ears syringed was suggested.[24]
Claims arising from ear syringing mishaps account for about 25% of the total claims received by New Zealand's Accident Compensation Corporation ENT Medical Misadventure Committee.[30] While high, this is not surprising, as ear syringing is an extremely common procedure. Grossan suggested that approximately 150,000 ears are irrigated each week in the United States, and about 40,000 per week in the United Kingdom.[37] Extrapolating from data obtained in Edinburgh, Sharp et al.[24] place this figure much higher, estimating that approximately 7000 ears are syringed per 100,000 population per annum. In the New Zealand claims mentioned above, perforation of the tympanic membrane was by far the most common injury resulting in significant disability.
History
De medicina
The treatment of ear wax was described by Aulus Cornelius Celsus in De Medicina in the 1st century:[38]
When a man is becoming dull of hearing, which happens most often after prolonged headaches, in the first place, the ear itself should be inspected: for there will be found either a crust such as comes upon the surface of ulcerations, or concretions of wax. If a crust, hot oil is poured in, or verdigris mixed with honey or leek juice or a little soda in honey wine. And when the crust has been separated from the ulceration, the ear is irrigated with tepid water, to make it easier for the crusts now disengaged to be withdrawn by the ear scoop. If it be wax, and if it be soft, it can be extracted in the same way by the ear scoop; but if hard, vinegar containing a little soda[39] is introduced; and when the wax has softened, the ear is washed out and cleared as above. ... Further, the ear should be syringed with castoreum mixed with vinegar and laurel oil and the juice of young radish rind, or with cucumber juice, mixed with crushed rose leaves. The dropping in of the juice of unripe grapes mixed with rose oil is also fairly efficacious against deafness.
Uses
- In medieval times, earwax and other substances such as urine were used to prepare pigments used by scribes to illustrate illuminated manuscripts.[40]
- The first lip balm may have been based on earwax.[41] The 1832 edition of the American Frugal Housewife said that "nothing was better than earwax to prevent the painful effects resulting from a wound by a nail [or] skewer"; and also recommended earwax as a remedy for cracked lips.[42]
- Before waxed thread was commonly available seamstresses would use their own earwax to stop the cut ends of threads from fraying.[43]
Other animals
- Many types of whales have a build-up of earwax which increases with time; the size of the deposit is sometimes the only way to determine the age of whales that do not have teeth.[44][45][46]
References
- ^ "Earwax". american-hearing.org. Chicago, Illinois: American Hearing Research Foundation. 2008.
- ^ a b Okuda I, Bingham B, Stoney P, Hawke M. (Jun 1991). "The organic composition of earwax". J Otolaryngol. (3): 212–5. PMID 1870171. CS1 maint: Uses authors parameter (link)
- ^ Alvord LS, Farmer BL (December 1997). "Anatomy and orientation of the human external ear". Journal of the American Academy of Audiology. 8 (6): 383–90. PMID 9433684.
- ^ a b Guest JF, Greener MJ, Robinson AC, Smith AF (August 2004). "Impacted cerumen: composition, production, epidemiology and management". QJM. 97 (8): 477–88. doi:10.1093/qjmed/hch082. PMID 15256605.
- ^ a b Overfield, Theresa (1985). Biologic variation in health and illness: race, age, and sex differences. Menlo Park, Calif: Addison-Wesley, Nursing Division. p. 46. ISBN 0-201-12810-1.
... most common type in Whites and Blacks is dark brown and moist. Dry wax, most common in Orientals and Native Americans, is gray and dry. It is flaky and may form a thin mass that lies in the ear canal.
- ^ Bass EJ, Jackson JF (September 1977). "Cerumen types in Eskimos". American Journal of Physical Anthropology. 47 (2): 209–10. doi:10.1002/ajpa.1330470203. PMID 910884.
- ^ "Miscellaneous musings on the Ainu, I". Ahnenkult.com. Retrieved 2014-04-28.
- ^ By Francie Diep (2014-02-13). "The Scent Of Your Earwax May Yield Valuable Information | Popular Science". Popsci.com. Retrieved 2014-04-28.
- ^ Online Mendelian Inheritance in Man (OMIM) 117800
- ^ Yoshiura K, Kinoshita A, Ishida T, et al. (March 2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nature Genetics. 38 (3): 324–30. doi:10.1038/ng1733. PMID 16444273.
- ^ Alberti PW (September 1964). "Epithelial migration on the tympanic membrane". The Journal of Laryngology and Otology. 78: 808–30. doi:10.1017/s0022215100062800. PMID 14205963.
- ^ Harvey DJ (September 1989). "Identification of long-chain fatty acids and alcohols from human cerumen by the use of picolinyl and nicotinate esters". Biomedical & Environmental Mass Spectrometry. 18 (9): 719–23. doi:10.1002/bms.1200180912. PMID 2790258.
- ^ Bortz JT, Wertz PW, Downing DT (November 1990). "Composition of cerumen lipids". Journal of the American Academy of Dermatology. 23 (5 Pt 1): 845–9. doi:10.1016/0190-9622(90)70301-W. PMID 2254469.
- ^ Nichols AC, Perry ET (September 1956). "Studies on the growth of bacteria in the human ear canal". The Journal of Investigative Dermatology. 27 (3): 165–70. doi:10.1038/jid.1956.22. PMID 13367525.
- ^ Chai TJ, Chai TC (October 1980). "Bactericidal activity of cerumen". Antimicrobial Agents and Chemotherapy. 18 (4): 638–41. doi:10.1128/aac.18.4.638. PMC 284062. PMID 7447422.
- ^ Stone M, Fulghum RS (1984). "Bactericidal activity of wet cerumen". The Annals of Otology, Rhinology, and Laryngology. 93 (2 Pt 1): 183–6. PMID 6370076.
- ^ Megarry S, Pett A, Scarlett A, Teh W, Zeigler E, Canter RJ (August 1988). "The activity against yeasts of human cerumen". The Journal of Laryngology and Otology. 102 (8): 671–2. doi:10.1017/s0022215100106115. PMID 3047287.
- ^ Roland PS, Marple BF (December 1997). "Disorders of the external auditory canal". Journal of the American Academy of Audiology. 8 (6): 367–78. PMID 9433682.
- ^ Campos A; Betancor L; Arias A; Rodrı´guez C; Herna´ndez AM; Lo´pez Aguado D; Sierra A (July 1998). "Study of common aerobic flora of human cerumen.". The Journal of Laryngology & Otology. 112 (7): 613–6. PMID 9775288.
- ^ Chou, R; Dana, T; Bougatsos, C; et al. (March 2011). "Screening for Hearing Loss in Adults Ages 50 Years and Older: A Review of the Evidence for the U.S. Preventive Services Task Force". Evidence Syntheses, No. 83. U.S. Agency for Healthcare Research and Quality (AHRQ). Retrieved 5 July 2013.
- ^ Oliveira RJ (December 1997). "The active earcanal". Journal of the American Academy of Audiology. 8 (6): 401–10. PMID 9433686.
- ^ Bryner, Jeanna. "Now Hear This: Don't Remove Earwax", LiveScience, 29 August 2008. Retrieved on 7 September 2008.
- ^ a b Clegg AJ, Loveman E, Gospodarevskaya E, et al. (June 2010). "The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation". Health Technol Assess. 14 (28): 1–192. doi:10.3310/hta14280. PMID 20546687.
- ^ a b c d e Sharp JF, Wilson JA, Ross L, Barr-Hamilton RM (December 1990). "Ear wax removal: a survey of current practice". BMJ. 301 (6763): 1251–3. doi:10.1136/bmj.301.6763.1251. PMC 1664378. PMID 2271824.
- ^ a b "Ear wax". Tchain.com. Retrieved 2010-05-02.
- ^ a b c Clegg, AJ; Loveman, E; Gospodarevskaya, E; Harris, P; Bird, A; Bryant, J; Scott, DA; Davidson, P; Little, P; Coppin, R (June 2010). "The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation.". Health technology assessment (Winchester, England). 14 (28): 1–192. doi:10.3310/hta14280. PMID 20546687.
- ^ Fraser JG (October 1970). "The efficacy of wax solvents: in vitro studies and a clinical trial". The Journal of Laryngology and Otology. 84 (10): 1055–64. doi:10.1017/s0022215100072856. PMID 5476901.
- ^ a b Wilson PL, Roeser RJ (December 1997). "Cerumen management: professional issues and techniques". Journal of the American Academy of Audiology. 8 (6): 421–30. PMID 9433688.
- ^ Coppin R, Wicke D, Little P (2011). "Randomized trial of bulb syringes for earwax: impact on health service utilization". Annals of Family Medicine. 9 (2): 110–4. doi:10.1370/afm.1229. PMC 3056857. PMID 21403136.
- ^ a b c d e Blake P, Matthews R, Hornibrook J (November 1998). "When not to syringe an ear". The New Zealand Medical Journal. 111 (1077): 422–4. PMID 9861921.
- ^ a b Ernst AA, Takakuwa KM, Letner C, Weiss SJ (September 1999). "Warmed versus room temperature saline solution for ear irrigation: a randomized clinical trial". Annals of Emergency Medicine. 34 (3): 347–50. doi:10.1016/S0196-0644(99)70129-0. PMID 10459091.
- ^ a b Bull, P. D. (2002). Lecture notes on diseases of the ear, nose, and throat (6th ed.). Oxford: Blackwell Science. pp. 26–27. ISBN 0-632-06506-0.
- ^ Evidences Based Cerumen Removal Protocol
- ^ Seely DR, Quigley SM, Langman AW (October 1996). "Ear candles--efficacy and safety". The Laryngoscope. 106 (10): 1226–9. doi:10.1097/00005537-199610000-00010. PMID 8849790.
- ^ a b "Earwax". www.entnet.org. American Academy of Otolaryngology. Retrieved 23 April 2012.
- ^ Leong AC, Aldren C (August 2005). "A non-randomized comparison of earwax removal with a 'do-it-yourself' ear vacuum kit and a Jobson-Horne probe". Clinical Otolaryngology. 30 (4): 320–3. doi:10.1111/j.1365-2273.2005.01020.x. PMID 16209672.
- ^ Grossan M (July 1998). "Cerumen removal--current challenges". Ear, Nose, & Throat Journal. 77 (7): 541–6, 548. PMID 9693470.
- ^ Celsus, Aulus Cornelius; W.G. Spencer translation. "Book VI". De Medicina.
- ^ "acetum et cum eo nitri paulum". Nitri is rendered as "soda" here, i.e. soda ash, though the word can refer to a variety of alkaline substances or to sodium nitrate. (http://www.archives.nd.edu/cgi-bin/words.exe?nitri http://www.history-science-technology.com/Notes/Notes%208.htm) Note that acidification of sodium carbonate yields sodium bicarbonate.
- ^ "Iberian manuscripts (pigments)". Web.ceu.hu. Retrieved 2014-04-28.
- ^ Schwaab, M; Gurr, A; Neumann, A; Dazert, S; Minovi, A (August 2011). "Human antimicrobial proteins in ear wax.". European Journal of Clinical Microbiology & Infectious Diseases. 30 (8): 997–1004. doi:10.1007/s10096-011-1185-2. PMID 21298458.
- ^ The American frugal housewife ... - Google Books. Books.google.ca. 1841. p. 116. Retrieved 2010-05-02.
- ^ Beaudry, Mary C., Bodkin Biographies Retrieved 2012-01-03
- ^ Craig S. Nelson. "What can you tell us about whale ear wax?". Cs.ucf.edu. Retrieved 2010-06-20.
- ^ Darren Osborne. "Ear Wax Reveals Whale's Tale".
- ^ Stephen J. Trumble, Eleanor M. Robinson, Michelle Berman-Kowalewski, Charles W. Potter, and Sascha Usenko (2013). "Blue whale earplug reveals lifetime contaminant exposure and hormone profiles". PNAS 2013: 1311418110v1-20131141
Further reading
- Roeser RJ, Ballachanda BB (December 1997). "Physiology, pathophysiology, and anthropology/epidemiology of human earcanal secretions". Journal of the American Academy of Audiology. 8 (6): 391–400. PMID 9433685.
- Stone M, Fulghum RS (1984). "Bactericidal activity of wet cerumen". The Annals of Otology, Rhinology, and Laryngology. 93 (2 Pt 1): 183–6. PMID 6370076.
- Bøe R, Silvola J, Yang J, et al. (September 1999). "Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium". Infection and Immunity. 67 (9): 4843–6. PMC 96817. PMID 10456939.
External links
| Look up earwax in Wiktionary, the free dictionary. |
| Wikimedia Commons has media related to Earwax. |
- Ear wax and its treatment Deafness Research UK
- Keeping the ear clean and removing wax: Fact Sheet at PubMed Health
- Clinical practice guideline: Cerumen impaction (The American Academy of Otolaryngology – Head and Neck Surgery)
UpToDate Contents
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- 1. 耳垢 cerumen
- 2. 成人における難聴の病因 etiology of hearing loss in adults
- 3. 小児における耳痛の評価 evaluation of earache in children
- 4. 小児における耳漏（耳だれ）の評価 evaluation of otorrhea ear discharge in children
- 5. 外耳道異物の診断およびマネージメント diagnosis and management of foreign bodies of the outer ear
English Journal
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- Martín-Santiago A1, Rodríguez-Pascual M2, Knöpfel N3, Hernández-Martín Á4.
- Actas dermo-sifiliograficas.Actas Dermosifiliogr.2015 Jul 20. pii: S0001-7310(15)00287-2. doi: 10.1016/j.ad.2015.06.003. [Epub ahead of print]
- BACKGROUND: Otological complications associated with non-syndromic autosomal recessive congenital ichthyosis (ARCI) have been poorly investigated.OBJECTIVES: Our aim was to determine the frequency and to characterize the otological manifestations of patients diagnosed of ARCI that are currently bein
- PMID 26206273
- A new approach for cerumenolytic treatment in children: In vivo and in vitro study.
- Soy FK1, Ozbay C2, Kulduk E3, Dundar R4, Yazıcı H5, Sakarya EU6.
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- OBJECTIVES: To demonstrate the effects of various cerumenolytic solutions in vivo and in vitro and to measure the change in pain following treatment.METHODS: The study was done as a single-centre, prospective and double-blind study. Among 1243 paediatric patients with total or nearly total occlusive
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- [Bilateral external auditory canal cholesteatoma - a case report].
- Roszkowska A1, Morawska-Kochman M1, Kubacka M1, Dorobisz K1, Kręcicki T1.
- Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.Pol Merkur Lekarski.2015 Jun;38(228):335-9.
- The external auditory canal cholesteatoma is a rare and difficult to diagnose disease. Symptoms are similar to the external ear canal inflammation and can be masked by retained cerumen. In the article we described a case of 22 year old, mentally impairment women with bilateral otorrhea, in the past
- PMID 26098654
Japanese Journal
- Meniere論文と19世紀の反応 : 第三騙:剖検症例
- 耳鼻咽喉科臨床 106(10), 961-964, 2013-10-01
- NAID 10031200183
- 高齢者の耳垢の頻度と認知機能,聴力との関連
- 日本老年医学会雑誌 49(3), 325-329, 2012-05
- NAID 40019365601
- 高齢者の耳垢の頻度と認知機能，聴力との関連
- 日本老年医学会雑誌 49(3), 325-329, 2012
- NAID 130004485819
Related Links
- cerumenとは。意味や和訳。[名][U]耳あか(earwax). - goo英和辞書は14万項目以上を収録し、発音、音声、慣用句、例文が分かる英和辞書です。
- Cerumen definition, earwax. See more. Thesaurus Translate Puzzles & Games Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In follow Dictionary.com Dictionary Thesaurus Translate More... [si ...
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