関: cotrimoxazole、trimethoprim-sulfamethoxazole、trimethoprim-sulfamethoxazole combination

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 07:10:15」(JST)

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Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes. Centrins are present in the centrioles and pericentriolar lattice.^[2]^[3] Human centrin genes are CETN1, CETN2 and CETN3. Centrin was first isolated and characterized from the flagellar roots of the green alga Tetraselmis striata.^[4]

Function

Centrins are required for duplication of centrioles.^[3] They may also play a role in severing of microtubules by causing calcium-mediated contraction.^[5] The majority of centrin in the cell is non-centrosomal whose function is not yet clear.^[6]

Structure

Centrin belongs to the EF-hand superfamily of calcium-binding proteins and has four calcium-binding EF-hands.^[7] It has a molecular weight of 20 kDa.^[8]

References

^ "RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex".
^ Baron, A. T.; Greenwood, T. M.; Bazinet, C. W.; Salisbury, J. L. (1992). "Centrin is a component of the pericentriolar lattice". Biology of the Cell / under the auspices of the European Cell Biology Organization 76 (3): 383–388. PMID 1305481. edit
^ ^a ^b Salisbury JL, Suino KM, Busby R, Springett M (2002). "Centrin-2 is required for centriole duplication in mammalian cells". Curr. Biol. 12 (15): 1287–92. doi:10.1016/S0960-9822(02)01019-9. PMID 12176356.
^ Salisbury JL, Baron A, Surek B, Melkonian M (1984). "Striated flagellar roots: isolation and partial characterization of a calcium-modulated contractile organelle". J. Cell Biol. 99 (3): 962–70. doi:10.1083/jcb.99.3.962. PMC 2113404. PMID 6381510.
^ Wolfrum, U. (1995). "Centrin in the photoreceptor cells of mammalian retinae". Cell motility and the cytoskeleton 32 (1): 55–64. doi:10.1002/cm.970320107. PMID 8674134. edit
^ Paoletti A, Moudjou M, Paintrand M, Salisbury JL, Bornens M (1996). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles". J. Cell. Sci. 109 (Pt 13): 3089–102. PMID 9004043.
^ Salisbury JL (1995). "Centrin, centrosomes, and mitotic spindle poles". Curr. Opin. Cell Biol. 7 (1): 39–45. doi:10.1016/0955-0674(95)80043-3. PMID 7755988.
^ Levy YY, Lai EY, Remillard SP, Heintzelman MB, Fulton C (1996). "Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs in Naegleria and other organisms". Cell Motil. Cytoskeleton 33 (4): 298–323. doi:10.1002/(SICI)1097-0169(1996)33:4<298::AID-CM6>3.0.CO;2-5. PMID 8801035.

English Journal

Herd-level relationship between antimicrobial use and presence or absence of antimicrobial resistance in gram-negative bovine mastitis pathogens on Canadian dairy farms.

Saini V, McClure JT, Scholl DT, Devries TJ, Barkema HW.SourceDepartment of Production Animal Health, University of Calgary, Calgary, Alberta, T2N 4N1, Canada; Canadian Bovine Mastitis Research Network, C. P. 5000, Saint-Hyacinthe, Québec, J2S 7C6, Canada. Electronic address: vineet.saini@albertahealthservices.ca.
Journal of dairy science.J Dairy Sci.2013 Aug;96(8):4965-76. doi: 10.3168/jds.2012-5713. Epub 2013 Jun 13.
Concurrent data on antimicrobial use (AMU) and resistance are needed to contain antimicrobial resistance (AMR) in bacteria. The present study examined a herd-level association between AMU and AMR in Escherichia coli (n=394) and Klebsiella species (n=139) isolated from bovine intramammary infections
PMID 23769367

Trimethoprim resistance of dihydrofolate reductase (DHFR) variants from clinical isolates of Pneumocystis jirovecii.

Queener SF, Cody V, Pace J, Torkelson P, Gangjee A.SourceDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jul 29. [Epub ahead of print]
Pneumocystis jirovecii is an opportunistic pathogen that causes serious pneumonia in immunosuppressed patients. Standard therapy and prophylaxis includes trimethoprim/sulfamethoxazole; trimethoprim in this combination targets dihydrofolate reductase (DHFR). Fourteen clinically observed variants of P
PMID 23896474

Germline deletion of Cetn1 causes infertility in male mice.

Avasthi P, Scheel JF, Ying G, Frederick JM, Baehr W, Wolfrum U.SourceDepartment of Ophthalmology, University of Utah Health Science Center, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA.
Journal of cell science.J Cell Sci.2013 Jul 15;126(Pt 14):3204-13. doi: 10.1242/jcs.128587. Epub 2013 May 2.
Centrins are calmodulin-like Ca(2+)-binding proteins that can be found in all ciliated eukaryotic cells from yeast to mammals. Expressed in male germ cells and photoreceptors, centrin 1 (CETN1) resides in the photoreceptor transition zone and connecting cilium. To identify its function in mammals, w
PMID 23641067

Japanese Journal

海産繊毛虫に含まれるOctocarinatus Centrinタンパク質のN末端に結合したEu(III)の電気化学特性

電気化学および工業物理化学 82(8), 663-669, 2014-08
NAID 40020143464

Electrochemistry of Eu(III) Binding to N-terminal of Euplotes Octocarinatus Centrin

Electrochemistry 82(8), 663-669, 2014
NAID 130004680080

Structure-function analysis of the EF-hand protein centrin-2 for its intracellular localization and nucleotide excision repair

Nucleic Acids Research 41(14), 6917-6929, 2013-08
NAID 120005621886

Related Pictures

Anti-Centrin 1 antibody (ab11257) | Abcam TECHNICAL CONSULTANT - CENTRIN AFATEC, PT | jobsDB Indonesia Berkas:Logo Centrin TV.jpg - Wikipedia bahasa Indonesia, ensiklopedia bebas Anti-Centrin 2 抗体 (ab196554) | アブカム CENTRIN - LIBRAS (@CENTRINLIBRAS1) | Twitter Centrin-2 Antibody (N-17)-R | Santa Cruz Biotech Anti Centrin 1 - Cosmo Bio Co.,Ltd. Anti-Centrin 1 antibody (ab11257) | Abcam

★リンクテーブル★

リンク元	「セントリン」「cotrimoxazole」「trimethoprim-sulfamethoxazole combination」

「セントリン」

Caltractin
	Crystal structure of the SdCen/skMLCK complex.
Identifiers
Organism	Scherffelia dubia
Symbol	caltractin
RefSeq (mRNA)	X69220
UniProt	Q06827
Other data